Influences of process and formulation parameters on powder flow properties and immunogenicity of spray dried polymer particles entrapping recombinant pneumococcal surface protein A

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 198-210

  Anish, Chakkumkal ^a   Upadhyay, Arun K ^a   Sehgal, Devinder ^a   Panda, Amulya Kumar ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Antibody response; Pneumococcal surface protein A (PspA); Polylactide particles; Powder flow properties; Spray drying

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN G; OUTER SURFACE PROTEIN A; POLYLACTIDE; POLYMER; POLYVINYL ALCOHOL; SOLVENT; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; PNEUMOCOCCAL SURFACE PROTEIN A; POLYESTER; POWDER; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; EVAPORATION; FACTORIAL DESIGN; FEMALE; IMMUNIZATION; IMMUNOGENICITY; MALE; NEBULIZATION; NONHUMAN; PARTICLE SIZE; POROSITY; POWDER; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SINGLE DRUG DOSE; SPRAY DRYING; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; DRUG FORMULATION; FLOW KINETICS; IMMUNOLOGY; MEDICINAL CHEMISTRY; SURFACE PROPERTY; WISTAR RAT;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; FEMALE; IMMUNIZATION; MALE; MICE, INBRED BALB C; PARTICLE SIZE; POLYESTERS; POWDERS; RATS, WISTAR; RECOMBINANT PROTEINS; RHEOLOGY; SURFACE PROPERTIES;

EID: 84896913951     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.025     Document Type: Article

References (29)

1. S.D. Allison Analysis of initial burst in PLGA microparticles Expert Opinion on Drug Delivery 5 2008 615 628 (Pubitemid 351998252)
2. C. Anish, D.G. Goswami, V. Kanchan, S. Mathew, and A.K. Panda The immunogenic characteristics associated with multivalent display of Vi polysaccharide antigen using biodegradable polymer particles Biomaterials 33 2012 6843 6857
3. B. Baras, M.A. Benoit, and J. Gillard Influence of various technological parameters on the preparation of spray-dried poly (epsilon-caprolactone) microparticles containing a model antigen Journal of Microencapsulation 17 2000 485 498 (Pubitemid 30420830)
4. B. Baras, M.A. Benoit, O. Poulain-Godefroy, A.M. Schacht, A. Capron, J. Gillard, and G. Riveau Vaccine properties of antigens entrapped in microparticles produced by spray-drying technique and using various polyester polymers Vaccine 18 2000 1495 1505 (Pubitemid 30017830)
5. D.E. Briles, S.K. Hollingshead, J. King, A. Swift, P.A. Braun, M.K. Park, L.M. Ferguson, M.H. Nahm, and G.S. Nabors Immunization of humans with recombinant pneumococcal surface protein A (r-PspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA Journal of Infectious Diseases 182 2000 1694 1701
6. D.E. Briles, R.C. Tart, E. Swiatlo, J.P. Dillard, P. Smith, K.A. Benton, B.A. Ralph, A. Brooks-Walter, M.J. Crain, S.K. Hollingshead, and L.S. McDaniel Pneumococcal diversity: considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA) Clinical Microbiology Reviews 11 1998 645 657 (Pubitemid 28497567)
7. C.C. Daniels, K.H. Kim, R.L. Burton, S. Mirza, M. Walker, J. King, Y. Hale, P. Coan, D.K. Rhee, M.H. Nahm, and D.E. Briles Modified opsonization, phagocytosis, and killing assays to measure potentially protective antibodies against pneumococcal surface protein A Clinical and Vaccine Immunology 20 2013 1549 1558
8. M.L. De Temmerman, J. Rejman, R.E. Vandenbroucke, S. De Koker, C. Libert, J. Grooten, J. Demeester, B. Gander, and S.C. De Smedt Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen Journal of Controlled Release 158 2012 233 239
9. S. Freitas, H.P. Merkle, and B. Gander Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology Journal of Controlled Release 102 2005 313 332 (Pubitemid 40093756)
10. C. Goulart, T.R. Da Silva, D. Rodriguez, W.R. Politano, L.C. Leite, and M. Darrieux Characterization of protective immune responses induced by pneumococcal surface protein A in fusion with pneumolysin derivatives Public Library of Science 8 2013 e59605
11. S.L. Haughney, L.K. Petersen, A.D. Schoofs, A.E. Ramer-Tait, J.D. King, D.E. Briles, M.J. Wannemuehler, and B. Narasimhan Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles Acta Biomaterialia 9 2013 8262 8271
12. M.J. Jedrzejas Pneumococcal virulence factors: structure and function Microbiology and Molecular Biology Reviews 65 2001 187 201
13. W.L. Jiang, and S.P. Schwendeman Stabilization and controlled release of bovine serum albumin encapsulated in poly (d, l-lactide) and poly (ethylene glycol) microsphere blends Pharmaceutical Research 18 2001 878 885 (Pubitemid 32783527)
14. W.L. Jiang, R.K. Gupta, M.C. Deshpande, and S.P. Schwendeman Biodegradable poly (lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens Advanced Drug Delivery Reviews 57 2005 391 410 (Pubitemid 39550967)
15. V. Kanchan, and A.K. Panda Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response Biomaterials 28 2007 5344 5357 (Pubitemid 47532191)
16. V. Kanchan, Y.K. Katare, and A.K. Panda Memory antibody response from antigen loaded polymer particles and the effect of antigen release kinetics Biomaterials 30 2009 4763 4776
17. Y.K. Katare, T. Muthukumaran, and A.K. Panda Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles International Journal of Pharmaceutics 301 2005 149 160 (Pubitemid 41206600)
18. Y.K. Katare, and A.K. Panda Immunogenicity and lower dose requirement of polymer entrapped tetanus toxoid co-administered with alum Vaccine 24 2006 3599 3608
19. Y.K. Katare, and A.K. Panda Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles European Journal of Pharmaceutical Sciences 28 2006 179 188 (Pubitemid 43766098)
20. I.G. Kong, A. Sato, Y. Yuki, T. Nochi, H. Takahashi, S. Sawada, M. Mejima, S. Kurokawa, K. Okada, S. Sato, D.E. Briles, J. Kunisawa, Y. Inoue, M. Yamamoto, K. Akiyoshi, and H. Kiyono Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae Infection and Immunity 81 2013 1625 1634
21. M. Korber PLGA erosion: solubility- or diffusion-controlled? Pharmaceutical Research 27 2010 2414 2420
22. Y.F. Maa, P.A. Nguyen, T. Sweeney, S.J. Shire, and C.C. Hsu Protein inhalation powders: spray drying vs spray freeze drying Pharmaceutical Research 16 1999 249 254 (Pubitemid 29135129)
23. C.T. Nguyen, S.Y. Kim, M.S. Kim, S.E. Lee, and J.H. Rhee Intranasal immunization with recombinant PspA fused with a flagellin enhances the cross-protective immunity against Streptococcus pneumoniae infection in mice Vaccine 29 2011 5731 5739
24. R.S. Raghuvanshi, S. Goyal, O. Singh, and A.K. Panda Stabilization of dichloromethane-induced protein denaturation during microencapsulation Pharmaceutical Development and Technology 3 1998 269 276 (Pubitemid 28310943)
25. S. Rohatgi, D. Dutta, S. Tahir, and D. Sehgal Molecular dissection of antibody responses against pneumococcal surface protein A: evidence for diverse D-H-less heavy chain gene usage and avidity maturation The Journal of Immunology 182 2009 5570 5585
26. S. Shi, and A.J. Hickey PLGA microparticles in respirable sizes enhances an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen TG10.4-Ag85B Pharmaceutical Research 27 2010 350 360
27. H. Tamber, P. Johansen, H.P. Merkle, and B. Gander Formulation aspects of biodegradable polymeric microspheres for antigen delivery Advanced Drug Delivery Reviews 57 2005 357 376 (Pubitemid 39555502)
28. R.K. Verma, A.K. Singh, M. Mohan, A.K. Agrawal, P.R. Verma, A. Gupta, and A. Misra Inhalable microparticles containing nitric oxide donor: saying NO to intracellular Mycobacterium tuberculosis Molecular Pharmacology 9 2012 3183 3189
29. R. Vehring Pharmaceutical particle engineering via spray drying Pharmaceutical Research 25 2008 999 1022