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Volumn 33, Issue 28, 2012, Pages 6843-6857

The immunogenic characteristics associated with multivalent display of Vi polysaccharide antigen using biodegradable polymer particles

Author keywords

Memory antibody titer; Multivalency; Particle phagocytosis; Polylactide particles; Vi polysaccharide antigens

Indexed keywords

ANTIBODY RESPONSE; ANTIBODY TITERS; CAPSULAR POLYSACCHARIDES; CARRIER PROTEINS; EXPERIMENTAL ANIMALS; MICRO-PARTICLES; MULTIVALENCY; POLY LACTIDE; POLYMER PARTICLES; POLYMERIC PARTICLES; POLYSACCHARIDE ANTIGEN; SALMONELLA TYPHI; SECONDARY ANTIBODIES; SINGLE-DOSE; TETANUS TOXOID;

EID: 84864019616     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.007     Document Type: Article
Times cited : (17)

References (54)
  • 1
    • 0033038260 scopus 로고    scopus 로고
    • Single-administration vaccines: controlled-release technology to mimic repeated immunizations
    • Cleland J.L. Single-administration vaccines: controlled-release technology to mimic repeated immunizations. Trends Biotechnol 1999, 17:25-29.
    • (1999) Trends Biotechnol , vol.17 , pp. 25-29
    • Cleland, J.L.1
  • 2
    • 9244253168 scopus 로고    scopus 로고
    • Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
    • Jiang W.L., Gupta R.K., Deshpande M.C., Schwendeman S.P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv Drug Deliv Rev 2005, 57:391-410.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 391-410
    • Jiang, W.L.1    Gupta, R.K.2    Deshpande, M.C.3    Schwendeman, S.P.4
  • 3
    • 4644328176 scopus 로고    scopus 로고
    • Novel approaches to vaccine delivery
    • O'Hagan D.T., Rappuoli R. Novel approaches to vaccine delivery. Pharm Res 2004, 21:1519-1530.
    • (2004) Pharm Res , vol.21 , pp. 1519-1530
    • O'Hagan, D.T.1    Rappuoli, R.2
  • 4
    • 0142058176 scopus 로고    scopus 로고
    • Recent advances in the discovery and delivery of vaccine adjuvants
    • O'Hagan D.T., Valiante N.M. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov 2003, 2:727-735.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 727-735
    • O'Hagan, D.T.1    Valiante, N.M.2
  • 5
    • 40649091858 scopus 로고    scopus 로고
    • Interaction of dendritic cells with biomaterials
    • Babensee J.E. Interaction of dendritic cells with biomaterials. Semin Immunol 2008, 20:101-108.
    • (2008) Semin Immunol , vol.20 , pp. 101-108
    • Babensee, J.E.1
  • 6
    • 34948832042 scopus 로고    scopus 로고
    • Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response
    • Kanchan V., Panda A.K. Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response. Biomaterials 2007, 28:5344-5357.
    • (2007) Biomaterials , vol.28 , pp. 5344-5357
    • Kanchan, V.1    Panda, A.K.2
  • 7
    • 77956494575 scopus 로고    scopus 로고
    • Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses
    • Oyewumi M.O., Kumar A., Cui Z. Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses. Expert Rev Vaccines 2010, 9:1095-1107.
    • (2010) Expert Rev Vaccines , vol.9 , pp. 1095-1107
    • Oyewumi, M.O.1    Kumar, A.2    Cui, Z.3
  • 8
    • 78349312737 scopus 로고    scopus 로고
    • Particle size affects the cellular response in macrophages
    • Yue H., Wei W., Yue Z., Lv P., Wang L., Ma G., et al. Particle size affects the cellular response in macrophages. Eur J Pharm Sci 2010, 41:650-657.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 650-657
    • Yue, H.1    Wei, W.2    Yue, Z.3    Lv, P.4    Wang, L.5    Ma, G.6
  • 9
    • 77952674646 scopus 로고    scopus 로고
    • Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
    • Cruz L.J., Tacken P.J., Fokkink R., Joosten B., Stuart M.C., Albericio F., et al. Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro. J Control Release 2010, 144:118-126.
    • (2010) J Control Release , vol.144 , pp. 118-126
    • Cruz, L.J.1    Tacken, P.J.2    Fokkink, R.3    Joosten, B.4    Stuart, M.C.5    Albericio, F.6
  • 11
    • 79960574815 scopus 로고    scopus 로고
    • Designing super selectivity in multivalent nano-particle binding
    • Martinez-Veracoechea F.J., Frenkel D. Designing super selectivity in multivalent nano-particle binding. Pro Natl Acad Sci USA 2011, 108:10963-10968.
    • (2011) Pro Natl Acad Sci USA , vol.108 , pp. 10963-10968
    • Martinez-Veracoechea, F.J.1    Frenkel, D.2
  • 12
    • 79953719048 scopus 로고    scopus 로고
    • Inhibition of influenza virus activity by multivalent glycoarchitectures with matched sizes
    • Papp I., Sieben C., Sisson A.L., Kostka J., Boettcher C., Ludwig K., et al. Inhibition of influenza virus activity by multivalent glycoarchitectures with matched sizes. ChemBioChem 2011, 12:887-895.
    • (2011) ChemBioChem , vol.12 , pp. 887-895
    • Papp, I.1    Sieben, C.2    Sisson, A.L.3    Kostka, J.4    Boettcher, C.5    Ludwig, K.6
  • 13
    • 79958816315 scopus 로고    scopus 로고
    • Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies
    • Venter P.A., Dirksen A., Thomas D., Manchester M., Dawson P.E., Schneemann A. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies. Biomacromolecules 2011, 12:2293-2301.
    • (2011) Biomacromolecules , vol.12 , pp. 2293-2301
    • Venter, P.A.1    Dirksen, A.2    Thomas, D.3    Manchester, M.4    Dawson, P.E.5    Schneemann, A.6
  • 15
    • 67651152577 scopus 로고    scopus 로고
    • Memory antibody response from antigen loaded polymer particles and the effect of antigen release kinetics
    • Kanchan V., Katare Y.K., Panda A.K. Memory antibody response from antigen loaded polymer particles and the effect of antigen release kinetics. Biomaterials 2009, 30:4763-4776.
    • (2009) Biomaterials , vol.30 , pp. 4763-4776
    • Kanchan, V.1    Katare, Y.K.2    Panda, A.K.3
  • 16
    • 84855784570 scopus 로고    scopus 로고
    • Soybean agglutinin coated PLA particles entrapping candidate vaccines induces enhanced primary and sustained secondary antibody response from single point immunization
    • Gupta R.K., Goswami D.G., Singh R.R., Surolia A., Panda A.K. Soybean agglutinin coated PLA particles entrapping candidate vaccines induces enhanced primary and sustained secondary antibody response from single point immunization. Eur J Pharm Sci 2012, 45:282-295.
    • (2012) Eur J Pharm Sci , vol.45 , pp. 282-295
    • Gupta, R.K.1    Goswami, D.G.2    Singh, R.R.3    Surolia, A.4    Panda, A.K.5
  • 17
    • 80053413863 scopus 로고    scopus 로고
    • An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response
    • Steenblock E.R., Fadel T., Labowsky M., Pober J.S., Fahmy T.M. An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response. J Biol Chem 2011, 286:34883-34892.
    • (2011) J Biol Chem , vol.286 , pp. 34883-34892
    • Steenblock, E.R.1    Fadel, T.2    Labowsky, M.3    Pober, J.S.4    Fahmy, T.M.5
  • 18
    • 80055103805 scopus 로고    scopus 로고
    • Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors
    • Zhou J., Patel T.R., Fu M., Bertram J.P., Saltzman W.M. Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors. Biomaterials 2012, 33:583-591.
    • (2012) Biomaterials , vol.33 , pp. 583-591
    • Zhou, J.1    Patel, T.R.2    Fu, M.3    Bertram, J.P.4    Saltzman, W.M.5
  • 19
    • 0018971086 scopus 로고
    • Immunochemical properties of Vi antigen from Salmonella typhi-Ty2: presence of 2 antigenic determinants
    • Szewczyk B., Taylor A. Immunochemical properties of Vi antigen from Salmonella typhi-Ty2: presence of 2 antigenic determinants. Infect Immun 1980, 29:539-544.
    • (1980) Infect Immun , vol.29 , pp. 539-544
    • Szewczyk, B.1    Taylor, A.2
  • 20
    • 0019160405 scopus 로고
    • Diversity of Vi-related antigens in the microcapsule of Salmonella typhi
    • Szewczyk B., Taylor A. Diversity of Vi-related antigens in the microcapsule of Salmonella typhi. Infect Immun 1980, 30:661-667.
    • (1980) Infect Immun , vol.30 , pp. 661-667
    • Szewczyk, B.1    Taylor, A.2
  • 21
    • 0035208530 scopus 로고    scopus 로고
    • Comparative tolerability and immunogenicity of Typherix (TM) or Typhim Vi (TM) in healthy adults - 0, 12-month and 0, 24-month administration
    • Lebacq E. Comparative tolerability and immunogenicity of Typherix (TM) or Typhim Vi (TM) in healthy adults - 0, 12-month and 0, 24-month administration. BioDrugs 2001, 15:5-12.
    • (2001) BioDrugs , vol.15 , pp. 5-12
    • Lebacq, E.1
  • 22
    • 0022550768 scopus 로고
    • Safety and immunogenicity of 2 Salmonella typhi Vi-capsular polysaccharide vaccines
    • Tacket C.O., Ferreccio C., Robbins J.B., Tsai C.M., Schulz D., Cadoz M., et al. Safety and immunogenicity of 2 Salmonella typhi Vi-capsular polysaccharide vaccines. J Infect Dis 1986, 154:342-345.
    • (1986) J Infect Dis , vol.154 , pp. 342-345
    • Tacket, C.O.1    Ferreccio, C.2    Robbins, J.B.3    Tsai, C.M.4    Schulz, D.5    Cadoz, M.6
  • 23
    • 2542584255 scopus 로고
    • Persistence of antibody-titers 3 years after vaccination with Vi polysaccharide vaccine against typhoid-fever
    • Tacket C.O., Levine M.M., Robbins J.B. Persistence of antibody-titers 3 years after vaccination with Vi polysaccharide vaccine against typhoid-fever. Vaccine 1988, 6:307-308.
    • (1988) Vaccine , vol.6 , pp. 307-308
    • Tacket, C.O.1    Levine, M.M.2    Robbins, J.B.3
  • 24
    • 0027952784 scopus 로고
    • Clinical and serological responses following primary and booster immunization with Salmonella typhi Vi capsular polysaccharide vaccines
    • Keitel W.A., Bond N.L., Zahradnik J.M., Cramton T.A., Robbins J.B. Clinical and serological responses following primary and booster immunization with Salmonella typhi Vi capsular polysaccharide vaccines. Vaccine 1994, 12:195-199.
    • (1994) Vaccine , vol.12 , pp. 195-199
    • Keitel, W.A.1    Bond, N.L.2    Zahradnik, J.M.3    Cramton, T.A.4    Robbins, J.B.5
  • 26
    • 77950480397 scopus 로고    scopus 로고
    • Carbohydrate vaccines: developing sweet solutions to sticky situations?
    • Astronomo R.D., Burton D.R. Carbohydrate vaccines: developing sweet solutions to sticky situations?. Nat Rev Drug Discov 2010, 9:308-324.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 308-324
    • Astronomo, R.D.1    Burton, D.R.2
  • 27
    • 0033214361 scopus 로고    scopus 로고
    • Glycoprotein conjugate vaccines
    • Lindberg A.A. Glycoprotein conjugate vaccines. Vaccine 1999, 17:S28-S36.
    • (1999) Vaccine , vol.17
    • Lindberg, A.A.1
  • 28
    • 79953250769 scopus 로고    scopus 로고
    • Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines
    • Poolman J., Borrow R. Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines. Expert Rev Vaccines 2011, 10:307-322.
    • (2011) Expert Rev Vaccines , vol.10 , pp. 307-322
    • Poolman, J.1    Borrow, R.2
  • 29
    • 84864001760 scopus 로고    scopus 로고
    • Synthesis of oligosaccharide-based glycoconjugate vaccines
    • Pozsgay V. Synthesis of oligosaccharide-based glycoconjugate vaccines. Glycobiology 2001, 11:933-934.
    • (2001) Glycobiology , vol.11 , pp. 933-934
    • Pozsgay, V.1
  • 30
    • 77957017140 scopus 로고    scopus 로고
    • Chemical conjugation of biomacromolecules: a mini-review
    • Farkas P., Bystricky S. Chemical conjugation of biomacromolecules: a mini-review. Chemical Papers 2010, 64:683-695.
    • (2010) Chemical Papers , vol.64 , pp. 683-695
    • Farkas, P.1    Bystricky, S.2
  • 31
    • 70549091222 scopus 로고    scopus 로고
    • Recent development in carbohydrate-based cancer vaccines
    • Guo Z., Wang Q. Recent development in carbohydrate-based cancer vaccines. Curr Opin Chem Biol 2009, 13:608-617.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 608-617
    • Guo, Z.1    Wang, Q.2
  • 32
    • 84958117632 scopus 로고
    • The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application
    • Hestrin S. The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. J Biol Chem 1949, 180:249-261.
    • (1949) J Biol Chem , vol.180 , pp. 249-261
    • Hestrin, S.1
  • 33
    • 33845476239 scopus 로고    scopus 로고
    • Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells
    • Yoshida M., Mata J., Babensee J.E. Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells. J Biomed Mater Res A 2007, 80A:7-12.
    • (2007) J Biomed Mater Res A , vol.80 A , pp. 7-12
    • Yoshida, M.1    Mata, J.2    Babensee, J.E.3
  • 34
    • 33646766149 scopus 로고    scopus 로고
    • Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles
    • Katare Y.K., Panda A.K. Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles. Eur J Pharm Sci 2006, 28:179-188.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 179-188
    • Katare, Y.K.1    Panda, A.K.2
  • 35
    • 23944462440 scopus 로고    scopus 로고
    • Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles
    • Katare Y.K., Muthukumaran T., Panda A.K. Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles. Int J Pharm 2005, 301:149-160.
    • (2005) Int J Pharm , vol.301 , pp. 149-160
    • Katare, Y.K.1    Muthukumaran, T.2    Panda, A.K.3
  • 36
    • 77955053157 scopus 로고    scopus 로고
    • Glycoconjugate vaccines and immune interference: a review
    • Dagan R., Poolman J., Siegrist C.-A. Glycoconjugate vaccines and immune interference: a review. Vaccine 2010, 28:5513-5523.
    • (2010) Vaccine , vol.28 , pp. 5513-5523
    • Dagan, R.1    Poolman, J.2    Siegrist, C.-A.3
  • 37
    • 61349200781 scopus 로고    scopus 로고
    • The influence of carrier protein on the immunogenicity of simultaneously administered conjugate vaccines in infants
    • Poellabauer E.M., Petermann R., Ehrlich H.J. The influence of carrier protein on the immunogenicity of simultaneously administered conjugate vaccines in infants. Vaccine 2009, 27:1674-1679.
    • (2009) Vaccine , vol.27 , pp. 1674-1679
    • Poellabauer, E.M.1    Petermann, R.2    Ehrlich, H.J.3
  • 38
    • 77955057942 scopus 로고    scopus 로고
    • Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies
    • Jegerlehner A., Wiesel M., Dietmeier K., Zabel F., Gatto D., Saudan P., et al. Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies. Vaccine 2010, 28:5503-5512.
    • (2010) Vaccine , vol.28 , pp. 5503-5512
    • Jegerlehner, A.1    Wiesel, M.2    Dietmeier, K.3    Zabel, F.4    Gatto, D.5    Saudan, P.6
  • 40
    • 0032728316 scopus 로고    scopus 로고
    • Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines
    • Guttormsen H.K., Sharpe A.H., Chandraker A.K., Brigtsen A.K., Sayegh M.H., Kasper D.L. Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines. Infect Immun 1999, 67:6375-6384.
    • (1999) Infect Immun , vol.67 , pp. 6375-6384
    • Guttormsen, H.K.1    Sharpe, A.H.2    Chandraker, A.K.3    Brigtsen, A.K.4    Sayegh, M.H.5    Kasper, D.L.6
  • 41
    • 67349229802 scopus 로고    scopus 로고
    • Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface
    • Lai Z., Schreiber J.R. Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface. Vaccine 2009, 27:3137-3144.
    • (2009) Vaccine , vol.27 , pp. 3137-3144
    • Lai, Z.1    Schreiber, J.R.2
  • 42
    • 68149158040 scopus 로고    scopus 로고
    • Parameters underlying distinct T cell-dependent polysaccharide-specific IgG responses to an intact gram-positive bacterium versus a soluble conjugate vaccine
    • Colino J., Chattopadhyay G., Sen G., Chen Q., Lees A., Canaday D.H., et al. Parameters underlying distinct T cell-dependent polysaccharide-specific IgG responses to an intact gram-positive bacterium versus a soluble conjugate vaccine. J Immunol 2009, 183:1551-1559.
    • (2009) J Immunol , vol.183 , pp. 1551-1559
    • Colino, J.1    Chattopadhyay, G.2    Sen, G.3    Chen, Q.4    Lees, A.5    Canaday, D.H.6
  • 43
    • 46149133368 scopus 로고
    • Role of the Vi-antigen of Salmonella typhi in resistance to host defense in vitro
    • Looney R.J., Steigbigel R.T. Role of the Vi-antigen of Salmonella typhi in resistance to host defense in vitro. J Lab Clin Med 1986, 108:506-516.
    • (1986) J Lab Clin Med , vol.108 , pp. 506-516
    • Looney, R.J.1    Steigbigel, R.T.2
  • 44
    • 0024408267 scopus 로고
    • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype-A
    • Small J.M., Mitchell T.G. Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype-A. Infect Immun 1989, 57:3751-3756.
    • (1989) Infect Immun , vol.57 , pp. 3751-3756
    • Small, J.M.1    Mitchell, T.G.2
  • 45
    • 77953377110 scopus 로고    scopus 로고
    • Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist
    • Garg R., Qadri A. Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist. J Immunol 2010, 184:5980-5987.
    • (2010) J Immunol , vol.184 , pp. 5980-5987
    • Garg, R.1    Qadri, A.2
  • 46
    • 0017340623 scopus 로고
    • Effects of pneumococcal mucopeptide and capsular polysaccharides on phagocytosis
    • Dhingra R.K., Williams R.C.J., Reed W.P. Effects of pneumococcal mucopeptide and capsular polysaccharides on phagocytosis. Infect Immun 1977, 15:169-174.
    • (1977) Infect Immun , vol.15 , pp. 169-174
    • Dhingra, R.K.1    Williams, R.C.J.2    Reed, W.P.3
  • 48
    • 17644370329 scopus 로고    scopus 로고
    • Cell biology of antigen processing in vitro and in vivo
    • Trombetta E.S., Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 2005, 23:975-1028.
    • (2005) Annu Rev Immunol , vol.23 , pp. 975-1028
    • Trombetta, E.S.1    Mellman, I.2
  • 49
    • 0035226597 scopus 로고    scopus 로고
    • Evaluation of a new Vi polysaccharide typhoid vaccine in children aged 2-5 years
    • (Reprinted from Journal of Pediatrics 1999;48:85-88)
    • Cordero-Yap L., Rivera R.G., Dispo A.P., Mallabo J. Evaluation of a new Vi polysaccharide typhoid vaccine in children aged 2-5 years. BioDrugs 2001, 15:27. (Reprinted from Journal of Pediatrics 1999;48:85-88).
    • (2001) BioDrugs , vol.15 , pp. 27
    • Cordero-Yap, L.1    Rivera, R.G.2    Dispo, A.P.3    Mallabo, J.4
  • 50
    • 0024398275 scopus 로고
    • Comparative immunogenicities of Vi polysaccharide-protein conjugates composed of cholera-toxin or its B-subunit as a carrier bound to high-molecular-weight or lower-molecular-weight Vi
    • Szu S.C., Li X.R., Schneerson R., Vickers J.H., Bryla D., Robbins J.B. Comparative immunogenicities of Vi polysaccharide-protein conjugates composed of cholera-toxin or its B-subunit as a carrier bound to high-molecular-weight or lower-molecular-weight Vi. Infect Immun 1989, 57:3823-3827.
    • (1989) Infect Immun , vol.57 , pp. 3823-3827
    • Szu, S.C.1    Li, X.R.2    Schneerson, R.3    Vickers, J.H.4    Bryla, D.5    Robbins, J.B.6
  • 51
    • 77956405814 scopus 로고    scopus 로고
    • The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant
    • de Veer M., Kemp J., Chatelier J., Elhay M.J., Meeusen E.N.T. The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine 2010, 28:6597-6602.
    • (2010) Vaccine , vol.28 , pp. 6597-6602
    • de Veer, M.1    Kemp, J.2    Chatelier, J.3    Elhay, M.J.4    Meeusen, E.N.T.5
  • 52
    • 0037081389 scopus 로고    scopus 로고
    • Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses
    • Kemp J.M., Kajihara M., Nagahara S., Sano A., Brandon M., Lofthouse S. Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses. Vaccine 2002, 20:1089-1098.
    • (2002) Vaccine , vol.20 , pp. 1089-1098
    • Kemp, J.M.1    Kajihara, M.2    Nagahara, S.3    Sano, A.4    Brandon, M.5    Lofthouse, S.6
  • 53
    • 74549164361 scopus 로고    scopus 로고
    • Physical and chemical characterization and immunologic properties of Salmonella enterica serovar typhi capsular polysaccharide-diphtheria toxoid conjugates
    • Cui C., Carbis R., An S.J., Jang H., Czerkinsky C., Szu S.C., et al. Physical and chemical characterization and immunologic properties of Salmonella enterica serovar typhi capsular polysaccharide-diphtheria toxoid conjugates. Clin Vaccine Immunol 2010, 17:73-79.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 73-79
    • Cui, C.1    Carbis, R.2    An, S.J.3    Jang, H.4    Czerkinsky, C.5    Szu, S.C.6
  • 54
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
    • Bachmann M.F., Jennings G.T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol 2010, 10:787-796.
    • (2010) Nat Rev Immunol , vol.10 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2


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