메뉴 건너뛰기




Volumn 10, Issue 4, 2014, Pages 437-444

Genetic, genomic and epigenetic studies as tools for elucidating disease pathogenesis in primary Sjögren's syndrome

Author keywords

epigenetics; genetics; genomics; microRNAs; Sj grens syndrome

Indexed keywords

B LYMPHOID TYROSINE KINASE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD40 LIGAND; DNA METHYLTRANSFERASE 1; GAMMA INTERFERON; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 12; INTERLEUKIN 23; MESSENGER RNA; MICRORNA 146A; OX40 LIGAND; PROTEIN TYROSINE KINASE; STAT4 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 84896910252     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2014.901888     Document Type: Review
Times cited : (9)

References (90)
  • 1
    • 0023034826 scopus 로고
    • Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjogren's syndrome
    • Fox RI, Pearson G, Vaughan JH. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjogren's syndrome. J Immunol 1986;137:3162-8
    • (1986) J Immunol , vol.137 , pp. 3162-3168
    • Fox, R.I.1    Pearson, G.2    Vaughan, J.H.3
  • 2
    • 0025818925 scopus 로고
    • Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjogren's syndrome
    • Mariette X, Gozlan J, Clerc D, et al. Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjogren's syndrome. Am J Med 1991;90:286-94
    • (1991) Am J Med , vol.90 , pp. 286-294
    • Mariette, X.1    Gozlan, J.2    Clerc, D.3
  • 3
    • 0024339583 scopus 로고
    • Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome
    • Saito I, Servenius B, Compton T, Fox RI. Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J Exp Med 1989;169:2191-8
    • (1989) J Exp Med , vol.169 , pp. 2191-2198
    • Saito, I.1    Servenius, B.2    Compton, T.3    Fox, R.I.4
  • 4
    • 0017780456 scopus 로고
    • Sjogren's syndrome association with HLA-Dw3
    • Chused TM, Kassan SS, Opelz G, et al. Sjogren's syndrome association with HLA-Dw3. N Engl J Med 1977;296:895-7
    • (1977) N Engl J Med , vol.296 , pp. 895-897
    • Chused, T.M.1    Kassan, S.S.2    Opelz, G.3
  • 5
    • 0027280663 scopus 로고
    • Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome
    • Kang HI, Fei HM, Saito I, et al. Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome. J Immunol 1993;150:3615-23
    • (1993) J Immunol , vol.150 , pp. 3615-3623
    • Kang, H.I.1    Fei, H.M.2    Saito, I.3
  • 6
    • 0036092482 scopus 로고    scopus 로고
    • Classification criteria for Sjogren's syndrome: A revised version of the European criteria proposed by the American-European Consensus Group
    • Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8
    • (2002) Ann Rheum Dis , vol.61 , pp. 554-558
    • Vitali, C.1    Bombardieri, S.2    Jonsson, R.3
  • 7
    • 84889637008 scopus 로고    scopus 로고
    • Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort
    • Rasmussen A, Ice JA, Li H, et al. Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Ann Rheum Dis 2014;73(1):31-8
    • (2014) Ann Rheum Dis , vol.73 , Issue.1 , pp. 31-38
    • Rasmussen, A.1    Ice, J.A.2    Li, H.3
  • 8
    • 84859739536 scopus 로고    scopus 로고
    • American College of Rheumatology classification criteria for Sjogren's syndrome: A data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort
    • Shiboski SC, Shiboski CH, Criswell L, et al. American College of Rheumatology classification criteria for Sjogren's syndrome: a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) 2012;64:475-87
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 475-487
    • Shiboski, S.C.1    Shiboski, M.A.2    Criswell, L.3
  • 9
    • 33644530664 scopus 로고    scopus 로고
    • Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome
    • Gottenberg JE, Cagnard N, Lucchesi C, et al. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc Natl Acad Sci USA 2006;103:2770-5
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2770-2775
    • Gottenberg, J.E.1    Cagnard, N.2    Lucchesi, C.3
  • 10
    • 77957768966 scopus 로고    scopus 로고
    • Activation of the type i interferon pathway in primary Sjogren's syndrome
    • Mavragani CP, Crow MK. Activation of the type I interferon pathway in primary Sjogren's syndrome. J Autoimmun 2010;35: 225-31
    • (2010) J Autoimmun , vol.35 , pp. 225-231
    • Mavragani, C.P.1    Crow, M.K.2
  • 11
    • 67349105006 scopus 로고    scopus 로고
    • Peripheral blood gene expression profiling in Sjogren's syndrome
    • Emamian ES, Leon JM, Lessard CJ, et al. Peripheral blood gene expression profiling in Sjogren's syndrome. Genes Immun 2009;10:285-96
    • (2009) Genes Immun , vol.10 , pp. 285-296
    • Emamian, E.S.1    Leon, J.M.2    Lessard, C.J.3
  • 12
    • 0037108385 scopus 로고    scopus 로고
    • Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling
    • Nishikomori R, Usui T, Wu CY, et al. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 2002;169:4388-98
    • (2002) J Immunol , vol.169 , pp. 4388-4398
    • Nishikomori, R.1    Usui, T.2    Wu, C.Y.3
  • 13
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111-22
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 14
    • 33750987918 scopus 로고    scopus 로고
    • Autoimmune disease aggregation in families with primary Sjogren's syndrome
    • Anaya JM, Tobon GJ, Vega P, Castiblanco J. Autoimmune disease aggregation in families with primary Sjogren's syndrome. J Rheumatol 2006;33: 2227-34
    • (2006) J Rheumatol , vol.33 , pp. 2227-2234
    • Anaya, J.M.1    Tobon, G.J.2    Vega, P.3    Castiblanco, J.4
  • 15
    • 33646681230 scopus 로고    scopus 로고
    • Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
    • Anaya JM, Castiblanco J, Tobon GJ, et al. Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus. J Autoimmun 2006;26:208-14
    • (2006) J Autoimmun , vol.26 , pp. 208-214
    • Anaya, J.M.1    Castiblanco, J.2    Tobon, G.J.3
  • 16
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 17
    • 13344259990 scopus 로고    scopus 로고
    • Mapping of a susceptibility locus for Crohn's disease on chromosome 16
    • Hugot JP, Laurent-Puig P, Gower-Rousseau C, et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996;379:821-3
    • (1996) Nature , vol.379 , pp. 821-823
    • Hugot, J.P.1    Laurent-Puig, P.2    Gower-Rousseau, C.3
  • 18
    • 33845601536 scopus 로고    scopus 로고
    • Genetic basis of Sjogren's syndrome. How strong is the evidence?
    • Anaya JM, Delgado-Vega AM, Castiblanco J. Genetic basis of Sjogren's syndrome. How strong is the evidence? Clin Dev Immunol 2006;13:209-22
    • (2006) Clin Dev Immunol , vol.13 , pp. 209-222
    • Anaya, J.M.1    Delgado-Vega, A.M.2    Castiblanco, J.3
  • 19
    • 79952280367 scopus 로고    scopus 로고
    • Association of EBF1, FAM167A (C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome
    • Nordmark G, Kristjansdottir G, Theander E, et al. Association of EBF1, FAM167A (C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome. Genes Immun 2011;12:100-9
    • (2011) Genes Immun , vol.12 , pp. 100-109
    • Nordmark, G.1    Kristjansdottir, G.2    Theander, E.3
  • 20
    • 84856070217 scopus 로고    scopus 로고
    • Emerging patterns of genetic overlap across autoimmune disorders
    • Richard-Miceli C, Criswell LA. Emerging patterns of genetic overlap across autoimmune disorders. Genome Med 2012;4:6
    • (2012) Genome Med , vol.4 , pp. 6
    • Richard-Miceli, C.1    Criswell, L.A.2
  • 21
    • 84887116043 scopus 로고    scopus 로고
    • Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome
    • Lessard CJ, Li H, Adrianto I, et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome. Nat Genet 2013;45(11):1284-92
    • (2013) Nat Genet , vol.45 , Issue.11 , pp. 1284-1292
    • Lessard, C.J.1    Li, H.2    Adrianto, I.3
  • 22
    • 84887085183 scopus 로고    scopus 로고
    • A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23
    • Li Y, Zhang K, Chen H, et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23. Nat Genet 2013;45:1361-5
    • (2013) Nat Genet , vol.45 , pp. 1361-1365
    • Li, Y.1    Zhang, K.2    Chen, H.3
  • 24
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson S, Nordmark G, Goring HH, et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005;76: 528-37
    • (2005) Am J Hum Genet , vol.76 , pp. 528-537
    • Sigurdsson, S.1    Nordmark, G.2    Goring, H.H.3
  • 25
    • 34247162727 scopus 로고    scopus 로고
    • Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE)
    • Demirci FY, Manzi S, Ramsey-Goldman R, et al. Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE). Ann Hum Genet 2007;71:308-11
    • (2007) Ann Hum Genet , vol.71 , pp. 308-311
    • Demirci, F.Y.1    Manzi, S.2    Ramsey-Goldman, R.3
  • 26
    • 34547541897 scopus 로고    scopus 로고
    • Opposed independent effects and epistasis in the complex association of IRF5 to SLE
    • Ferreiro-Neira I, Calaza M, Alonso-Perez E, et al. Opposed independent effects and epistasis in the complex association of IRF5 to SLE. Genes Immun 2007;8:429-38
    • (2007) Genes Immun , vol.8 , pp. 429-438
    • Ferreiro-Neira, I.1    Calaza, M.2    Alonso-Perez, E.3
  • 27
    • 34249860408 scopus 로고    scopus 로고
    • Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
    • Graham RR, Kyogoku C, Sigurdsson S, et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci USA 2007;104:6758-63
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6758-6763
    • Graham, R.R.1    Kyogoku, C.2    Sigurdsson, S.3
  • 28
    • 42549152933 scopus 로고    scopus 로고
    • Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans
    • Kelly JA, Kelley JM, Kaufman KM, et al. Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans. Genes Immun 2008;9:187-94
    • (2008) Genes Immun , vol.9 , pp. 187-194
    • Kelly, J.A.1    Kelley, J.M.2    Kaufman, K.M.3
  • 29
    • 37349039478 scopus 로고    scopus 로고
    • The genetics and biology of Irf5-mediated signaling in lupus
    • Kozyrev SV, Alarcon-Riquelme ME. The genetics and biology of Irf5-mediated signaling in lupus. Autoimmunity 2007;40: 591-601
    • (2007) Autoimmunity , vol.40 , pp. 591-601
    • Kozyrev, S.V.1    Alarcon-Riquelme, M.E.2
  • 30
    • 34247254495 scopus 로고    scopus 로고
    • Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus
    • Kozyrev SV, Lewen S, Reddy PM, et al. Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus. Arthritis Rheum 2007;56:1234-41
    • (2007) Arthritis Rheum , vol.56 , pp. 1234-1241
    • Kozyrev, S.V.1    Lewen, S.2    Reddy, P.M.3
  • 31
    • 34250369117 scopus 로고    scopus 로고
    • Genetic association of IRF5 with SLE in Mexicans: Higher frequency of the risk haplotype and its homozygosity than Europeans
    • Reddy MV, Velazquez-Cruz R, Baca V, et al. Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygosity than Europeans. Hum Genet 2007;121:721-7
    • (2007) Hum Genet , vol.121 , pp. 721-727
    • Reddy, M.V.1    Velazquez-Cruz, R.2    Baca, V.3
  • 32
    • 34247628971 scopus 로고    scopus 로고
    • Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population
    • Shin HD, Sung YK, Choi CB, et al. Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population. Arthritis Res Ther 2007;9:R32
    • (2007) Arthritis Res Ther , vol.9
    • Shin, H.D.1    Sung, Y.K.2    Choi, C.B.3
  • 33
    • 39549092431 scopus 로고    scopus 로고
    • Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese
    • Siu HO, Yang W, Lau CS, et al. Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese. J Rheumatol 2008;35:360-2
    • (2008) J Rheumatol , vol.35 , pp. 360-362
    • Siu, H.O.1    Yang, W.2    Lau, C.S.3
  • 34
    • 37149055953 scopus 로고    scopus 로고
    • Association of an IRF5 gene functional polymorphism with Sjogren's syndrome
    • Miceli-Richard C, Comets E, Loiseau P, et al. Association of an IRF5 gene functional polymorphism with Sjogren's syndrome. Arthritis Rheum 2007;56: 3989-94
    • (2007) Arthritis Rheum , vol.56 , pp. 3989-3994
    • Miceli-Richard, C.1    Comets, E.2    Loiseau, P.3
  • 35
    • 59149104204 scopus 로고    scopus 로고
    • Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome
    • Nordmark G, Kristjansdottir G, Theander E, et al. Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome. Genes Immun 2009;10:68-76
    • (2009) Genes Immun , vol.10 , pp. 68-76
    • Nordmark, G.1    Kristjansdottir, G.2    Theander, E.3
  • 36
    • 36249002287 scopus 로고    scopus 로고
    • An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases
    • Dideberg V, Kristjansdottir G, Milani L, et al. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet 2007;16:3008-16
    • (2007) Hum Mol Genet , vol.16 , pp. 3008-3016
    • Dideberg, V.1    Kristjansdottir, G.2    Milani, L.3
  • 37
    • 45249112573 scopus 로고    scopus 로고
    • Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations
    • Kristjansdottir G, Sandling JK, Bonetti A, et al. Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet 2008;45(6):362-9
    • (2008) J Med Genet , vol.45 , Issue.6 , pp. 362-369
    • Kristjansdottir, G.1    Sandling, J.K.2    Bonetti, A.3
  • 38
    • 80053552366 scopus 로고    scopus 로고
    • Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies
    • Wang C, Kokkonen H, Sandling JK, et al. Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies. J Rheumatol 2011;38:2130-2
    • (2011) J Rheumatol , vol.38 , pp. 2130-2132
    • Wang, C.1    Kokkonen, H.2    Sandling, J.K.3
  • 39
    • 67650074526 scopus 로고    scopus 로고
    • The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjogren's syndrome
    • Miceli-Richard C, Gestermann N, Ittah M, et al. The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjogren's syndrome. Arthritis Rheum 2009;60:1991-7
    • (2009) Arthritis Rheum , vol.60 , pp. 1991-1997
    • Miceli-Richard, C.1    Gestermann, N.2    Ittah, M.3
  • 40
    • 34548427925 scopus 로고    scopus 로고
    • STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    • Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007;357:977-86
    • (2007) N Engl J Med , vol.357 , pp. 977-986
    • Remmers, E.F.1    Plenge, R.M.2    Lee, A.T.3
  • 41
    • 0034723184 scopus 로고    scopus 로고
    • Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2
    • Farrar JD, Smith JD, Murphy TL, Murphy KM. Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. J Biol Chem 2000;275:2693-7
    • (2000) J Biol Chem , vol.275 , pp. 2693-2697
    • Farrar, J.D.1    Smith, J.D.2    Murphy, T.L.3    Murphy, K.M.4
  • 42
    • 0037144547 scopus 로고    scopus 로고
    • Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    • Nguyen KB, Watford WT, Salomon R, et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 2002;297:2063-6
    • (2002) Science , vol.297 , pp. 2063-2066
    • Nguyen, K.B.1    Watford, W.T.2    Salomon, R.3
  • 43
    • 59849096879 scopus 로고    scopus 로고
    • Cutting edge: Autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo
    • Kariuki SN, Kirou KA, MacDermott EJ, et al. Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. J Immunol 2009;182:34-8
    • (2009) J Immunol , vol.182 , pp. 34-38
    • Kariuki, S.N.1    Kirou, K.A.2    Macdermott, E.J.3
  • 44
    • 77954886593 scopus 로고    scopus 로고
    • STAT4 is a confirmed genetic risk factor for Sjogren's syndrome and could be involved in type 1 interferon pathway signaling
    • Gestermann N, Mekinian A, Comets E, et al. STAT4 is a confirmed genetic risk factor for Sjogren's syndrome and could be involved in type 1 interferon pathway signaling. Genes Immun 2010;11:432-8
    • (2010) Genes Immun , vol.11 , pp. 432-438
    • Gestermann, N.1    Mekinian, A.2    Comets, E.3
  • 45
    • 77951826130 scopus 로고    scopus 로고
    • Influence of STAT4 polymorphism in primary Sjogren's syndrome
    • Palomino-Morales RJ, Diaz-Gallo LM, Witte T, et al. Influence of STAT4 polymorphism in primary Sjogren's syndrome. J Rheumatol 2010;37:1016-19
    • (2010) J Rheumatol , vol.37 , pp. 1016-1019
    • Palomino-Morales, R.J.1    Diaz-Gallo, L.M.2    Witte, T.3
  • 46
    • 70449730890 scopus 로고    scopus 로고
    • STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk
    • Abelson AK, Delgado-Vega AM, Kozyrev SV, et al. STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis 2009;68: 1746-53
    • (2009) Ann Rheum Dis , vol.68 , pp. 1746-1753
    • Abelson, A.K.1    Delgado-Vega, A.M.2    Kozyrev, S.V.3
  • 47
    • 40049108936 scopus 로고    scopus 로고
    • Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    • Hom G, Graham RR, Modrek B, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008;358:900-9
    • (2008) N Engl J Med , vol.358 , pp. 900-909
    • Hom, G.1    Graham, R.R.2    Modrek, B.3
  • 48
    • 75349113494 scopus 로고    scopus 로고
    • Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
    • Gourh P, Agarwal SK, Martin E, et al. Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations. J Autoimmun 2010;34:155-62
    • (2010) J Autoimmun , vol.34 , pp. 155-162
    • Gourh, P.1    Agarwal, S.K.2    Martin, E.3
  • 49
    • 84876963178 scopus 로고    scopus 로고
    • Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: Results from a large trans-ethnic meta-analysis
    • Genin E, Coustet B, Allanore Y, et al. Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis. PLoS ONE 2013;8:e61044
    • (2013) PLoS ONE , vol.8
    • Genin, E.1    Coustet, B.2    Allanore, Y.3
  • 50
    • 5444223519 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    • Boone DL, Turer EE, Lee EG, et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 2004;5:1052-60
    • (2004) Nat Immunol , vol.5 , pp. 1052-1060
    • Boone, D.L.1    Turer, E.E.2    Lee, E.G.3
  • 51
    • 3943054838 scopus 로고    scopus 로고
    • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    • Wertz IE, O'Rourke KM, Zhou H, et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004;430:694-9
    • (2004) Nature , vol.430 , pp. 694-699
    • Wertz, I.E.1    O'Rourke, K.M.2    Zhou, H.3
  • 52
    • 0032939356 scopus 로고    scopus 로고
    • The cytokineinducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
    • Heyninck K, Beyaert R. The cytokineinducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett 1999;442: 147-50
    • (1999) FEBS Lett , vol.442 , pp. 147-150
    • Heyninck, K.1    Beyaert, R.2
  • 53
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • Lee EG, Boone DL, Chai S, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289:2350-4
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1    Boone, D.L.2    Chai, S.3
  • 54
    • 39549107115 scopus 로고    scopus 로고
    • Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
    • Turer EE, Tavares RM, Mortier E, et al. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med 2008;205:451-64
    • (2008) J Exp Med , vol.205 , pp. 451-464
    • Turer, E.E.1    Tavares, R.M.2    Mortier, E.3
  • 55
    • 72949102226 scopus 로고    scopus 로고
    • A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    • Oshima N, Ishihara S, Rumi MA, et al. A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol 2010; 159(2):185-98
    • (2010) Clin Exp Immunol , vol.159 , Issue.2 , pp. 185-198
    • Oshima, N.1    Ishihara, S.2    Rumi, M.A.3
  • 56
    • 36549003138 scopus 로고    scopus 로고
    • Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    • Plenge RM, Cotsapas C, Davies L, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007;39:1477-82
    • (2007) Nat Genet , vol.39 , pp. 1477-1482
    • Plenge, R.M.1    Cotsapas, C.2    Davies, L.3
  • 57
    • 78649319964 scopus 로고    scopus 로고
    • Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
    • Bowes J, Lawrence R, Eyre S, et al. Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis. Hum Genet 2010;128:627-33
    • (2010) Hum Genet , vol.128 , pp. 627-633
    • Bowes, J.1    Lawrence, R.2    Eyre, S.3
  • 58
    • 50449111452 scopus 로고    scopus 로고
    • Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    • Graham RR, Cotsapas C, Davies L, et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008;40:1059-61
    • (2008) Nat Genet , vol.40 , pp. 1059-1061
    • Graham, R.R.1    Cotsapas, C.2    Davies, L.3
  • 59
    • 50449103533 scopus 로고    scopus 로고
    • Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    • Musone SL, Taylor KE, Lu TT, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008;40:1062-4
    • (2008) Nat Genet , vol.40 , pp. 1062-1064
    • Musone, S.L.1    Taylor, K.E.2    Lu, T.T.3
  • 60
    • 84867898782 scopus 로고    scopus 로고
    • A20: Linking a complex regulator of ubiquitylation to immunity and human disease
    • Ma A, Malynn BA. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol 2012;12: 774-85
    • (2012) Nat Rev Immunol , vol.12 , pp. 774-785
    • Ma, A.1    Malynn, B.A.2
  • 61
    • 79955471681 scopus 로고    scopus 로고
    • Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    • Musone SL, Taylor KE, Nititham J, et al. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases. Genes Immun 2011;12:176-82
    • (2011) Genes Immun , vol.12 , pp. 176-182
    • Musone, S.L.1    Taylor, K.E.2    Nititham, J.3
  • 62
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato M, Sanada M, Kato I, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature 2009;459:712-16
    • (2009) Nature , vol.459 , pp. 712-716
    • Kato, M.1    Sanada, M.2    Kato, I.3
  • 63
    • 66549086135 scopus 로고    scopus 로고
    • The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    • Novak U, Rinaldi A, Kwee I, et al. The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas. Blood 2009;113:4918-21
    • (2009) Blood , vol.113 , pp. 4918-4921
    • Novak, U.1    Rinaldi, A.2    Kwee, I.3
  • 64
    • 66049124247 scopus 로고    scopus 로고
    • TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    • Schmitz R, Hansmann ML, Bohle V, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med 2009;206:981-9
    • (2009) J Exp Med , vol.206 , pp. 981-989
    • Schmitz, R.1    Hansmann, M.L.2    Bohle, V.3
  • 65
    • 27844511909 scopus 로고    scopus 로고
    • The risk of lymphoma development in autoimmune diseases: A meta-analysis
    • Zintzaras E, Voulgarelis M, Moutsopoulos HM. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med 2005;165: 2337-44
    • (2005) Arch Intern Med , vol.165 , pp. 2337-2344
    • Zintzaras, E.1    Voulgarelis, M.2    Moutsopoulos, H.M.3
  • 66
    • 84892848904 scopus 로고    scopus 로고
    • Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome
    • Nocturne G, Boudaoud S, Miceli-Richard C, et al. Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome. Blood 2013;122(25):4068-76
    • (2013) Blood , vol.122 , Issue.25 , pp. 4068-4076
    • Nocturne, G.1    Boudaoud, S.2    Miceli-Richard, C.3
  • 67
    • 37549016379 scopus 로고    scopus 로고
    • Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
    • Cunninghame Graham DS, Graham RR, et al. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 2008;40:83-9
    • (2008) Nat Genet , vol.40 , pp. 83-89
    • Cunninghame Graham, D.S.1    Graham, R.R.2
  • 68
    • 77949451240 scopus 로고    scopus 로고
    • Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis
    • Gourh P, Arnett FC, Tan FK, et al. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. Ann Rheum Dis 2010;69: 550-5
    • (2010) Ann Rheum Dis , vol.69 , pp. 550-555
    • Gourh, P.1    Arnett, F.C.2    Tan, F.K.3
  • 69
    • 34648835408 scopus 로고    scopus 로고
    • Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse
    • Achiron A, Feldman A, Mandel M, Gurevich M. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann N Y Acad Sci 2007;1107:155-67
    • (2007) Ann N y Acad Sci , vol.1107 , pp. 155-167
    • Achiron, A.1    Feldman, A.2    Mandel, M.3    Gurevich, M.4
  • 70
    • 34548786857 scopus 로고    scopus 로고
    • Gene expression in peripheral blood mononuclear cells from children with diabetes
    • Kaizer EC, Glaser CL, Chaussabel D, et al. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007;92: 3705-11
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3705-3711
    • Kaizer, E.C.1    Glaser, C.L.2    Chaussabel, D.3
  • 71
    • 3042844142 scopus 로고    scopus 로고
    • Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli
    • Peterson KS, Huang JF, Zhu J, et al. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest 2004;113:1722-33
    • (2004) J Clin Invest , vol.113 , pp. 1722-1733
    • Peterson, K.S.1    Huang, J.F.2    Zhu, J.3
  • 72
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler EC, Batliwalla FM, Karypis G, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003;100:2610-15
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2610-2615
    • Baechler, E.C.1    Batliwalla, F.M.2    Karypis, G.3
  • 73
    • 0242456113 scopus 로고    scopus 로고
    • Microarray analysis of gene expression in lupus
    • Crow MK, Wohlgemuth J. Microarray analysis of gene expression in lupus. Arthritis Res Ther 2003;5:279-87
    • (2003) Arthritis Res Ther , vol.5 , pp. 279-287
    • Crow, M.K.1    Wohlgemuth, J.2
  • 74
    • 0141986842 scopus 로고    scopus 로고
    • Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray
    • Han GM, Chen SL, Shen N, et al. Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray. Genes Immun 2003;4:177-86
    • (2003) Genes Immun , vol.4 , pp. 177-186
    • Han, G.M.1    Chen, S.L.2    Shen, N.3
  • 75
    • 17244372491 scopus 로고    scopus 로고
    • Activation of the type i interferon system in primary Sjogren's syndrome: A possible etiopathogenic mechanism
    • Bave U, Nordmark G, Lovgren T, et al. Activation of the type I interferon system in primary Sjogren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum 2005;52:1185-95
    • (2005) Arthritis Rheum , vol.52 , pp. 1185-1195
    • Bave, U.1    Nordmark, G.2    Lovgren, T.3
  • 76
    • 18644364840 scopus 로고    scopus 로고
    • Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects
    • Hjelmervik TO, Petersen K, Jonassen I, et al. Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects. Arthritis Rheum 2005;52: 1534-44
    • (2005) Arthritis Rheum , vol.52 , pp. 1534-1544
    • Hjelmervik, T.O.1    Petersen, K.2    Jonassen, I.3
  • 77
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 78
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006;103:12481-6
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 79
    • 79959784552 scopus 로고    scopus 로고
    • Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
    • Stagakis E, Bertsias G, Verginis P, et al. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 2011; 70(8):1496-506
    • (2011) Ann Rheum Dis , vol.70 , Issue.8 , pp. 1496-1506
    • Stagakis, E.1    Bertsias, G.2    Verginis, P.3
  • 80
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA- 146A contributes to abnormal activation of the type i interferon pathway in human lupus by targeting the key signaling proteins
    • Tang Y, Luo X, Cui H, et al. MicroRNA- 146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009;60:1065-75
    • (2009) Arthritis Rheum , vol.60 , pp. 1065-1075
    • Tang, Y.1    Luo, X.2    Cui, H.3
  • 81
    • 77951233965 scopus 로고    scopus 로고
    • MicroRNAs: Novel regulators involved in the pathogenesis of psoriasis?
    • Sonkoly E, Wei T, Janson PC, et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One 2007;2:e610
    • (2007) PLoS One , vol.2
    • Sonkoly, E.1    Wei, T.2    Janson, P.C.3
  • 82
    • 79958053053 scopus 로고    scopus 로고
    • The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis
    • Nakasa T, Shibuya H, Nagata Y, et al. The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 2011;63:1582-90
    • (2011) Arthritis Rheum , vol.63 , pp. 1582-1590
    • Nakasa, T.1    Shibuya, H.2    Nagata, Y.3
  • 83
    • 79959720798 scopus 로고    scopus 로고
    • Altered miR-146a expression in Sjogren's syndrome and its functional role in innate immunity
    • Pauley KM, Stewart CM, Gauna AE, et al. Altered miR-146a expression in Sjogren's syndrome and its functional role in innate immunity. Eur J Immunol 2011;41:2029-39
    • (2011) Eur J Immunol , vol.41 , pp. 2029-2039
    • Pauley, K.M.1    Stewart, C.M.2    Gauna, A.E.3
  • 84
    • 79551656688 scopus 로고    scopus 로고
    • MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjogren's syndrome
    • Alevizos I, Alexander S, Turner RJ, Illei GG. MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjogren's syndrome. Arthritis Rheum 2011;63:535-44
    • (2011) Arthritis Rheum , vol.63 , pp. 535-544
    • Alevizos, I.1    Alexander, S.2    Turner, R.J.3    Illei, G.G.4
  • 85
    • 38449116161 scopus 로고    scopus 로고
    • Demethylation of CD40LG on the inactive X in T cells from women with lupus
    • Lu Q, Wu A, Tesmer L, et al. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 2007;179:6352-8
    • (2007) J Immunol , vol.179 , pp. 6352-6358
    • Lu, Q.1    Wu, A.2    Tesmer, L.3
  • 86
    • 0021075736 scopus 로고
    • Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation
    • Lieberman MW, Beach LR, Palmiter RD. Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation. Cell 1983;35:207-14
    • (1983) Cell , vol.35 , pp. 207-214
    • Lieberman, M.W.1    Beach, L.R.2    Palmiter, R.D.3
  • 87
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E, Golbus J, Maybaum J, et al. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988;140:2197-200
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3
  • 88
    • 84890891041 scopus 로고    scopus 로고
    • Upregulation of membrane-bound CD40L on CD4+ T cells in women with primary Sjogren's syndrome
    • Belkhir R, Gestermann N, Koutero M, et al. Upregulation of membrane-bound CD40L on CD4+ T cells in women with primary Sjogren's syndrome. Scand J Immunol 2014;79:37-42
    • (2014) Scand J Immunol , vol.79 , pp. 37-42
    • Belkhir, R.1    Gestermann, N.2    Koutero, M.3
  • 89
    • 84873703760 scopus 로고    scopus 로고
    • Methylation profile of the promoter region of IRF5 in primary Sjogren's syndrome
    • Gestermann N, Koutero M, Belkhir R, et al. Methylation profile of the promoter region of IRF5 in primary Sjogren's syndrome. Eur Cytokine Netw 2013;23: 166-72
    • (2013) Eur Cytokine Netw , vol.23 , pp. 166-172
    • Gestermann, N.1    Koutero, M.2    Belkhir, R.3
  • 90
    • 84896266991 scopus 로고    scopus 로고
    • Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjogren's syndrome
    • Altorok N, Coit P, Hughes T, et al. Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjogren's syndrome. Arthritis Rheumatol 2014;66:731-9
    • (2014) Arthritis Rheumatol , vol.66 , pp. 731-739
    • Altorok, N.1    Coit, P.2    Hughes, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.