Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) for the treatment of allergic inflammatory diseases

Journal of Medicinal Chemistry

Volumn 57, Issue 4, 2014, Pages 1299-1322

  Kaila, Neelu ^a   Follows, Bruce ^a   Leung, Louis ^a   Thomason, Jennifer ^a   Huang, Adrian ^a   Moretto, Alessandro ^a   Janz, Kristin ^a   Lowe, Michael ^a   Mansour, Tarek S ^a   Hubeau, Cedric ^a   Page, Karen ^a   Morgan, Paul ^a   Fish, Susan ^a   Xu, Xin ^a   Williams, Cara ^a   Saiah, Eddine ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; CRA 680; INDOLEACETIC ACID; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG SYNTHESIS; GUINEA PIG; HAPLORHINI; HOUSE DUST; NONHUMAN; TH2 CELL;

ACETATES; HUMANS; HYPERSENSITIVITY; INFLAMMATION; QUINOLONES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; TH2 CELLS;

EID: 84896896421     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401509e     Document Type: Article

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