Modeling of asthma, COPD and cystic fibrosis in sheep

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 5, 2008, Pages 743-754

  Abraham, William M ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Airway inflammation; Animal models; Bronchoconstriction; Mucus clearance

Indexed keywords

[4 (4 BROMOPHENYLSULFONYLCARBAMOYL)BENZOYL]VALYLPROLINE N (2 METHYL 1 TRIFLUOROACETYLPROPYL)AMIDE; ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; ANTIHISTAMINIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIMOSIAMOSE; BUDESONIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CROMOGLYCATE DISODIUM; DU1 29; DU12 9; INDOMETACIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MECA 79; METHYLXANTHINE; MONOCLONAL ANTIBODY; MONTELUKAST; NONSTEROID ANTIINFLAMMATORY AGENT; PRANLUKAST; SALBUTAMOL; SELECTIN; STEROID; TBC 265; TECHNETIUM SULFUR COLLOID TC 99M; TOMELUKAST; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

AIRWAY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COLD AIR; CYSTIC FIBROSIS; DRUG EFFECT; DRUG TARGETING; HUMAN; INFLAMMATION; LUNG FUNCTION; LUNG LAVAGE; MUCOCILIARY CLEARANCE; NONHUMAN; PATHOPHYSIOLOGY; POLLUTANT; PRIORITY JOURNAL; PROVOCATION TEST; SCINTILLATION CAMERA; SHEEP;

ANIMALS; ASTHMA; CYSTIC FIBROSIS; DISEASE MODELS, ANIMAL; HUMANS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SHEEP; SHEEP DISEASES;

EID: 50849140491     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.01.010     Document Type: Article

References (82)

1. Abraham W.M. Animal models of asthma. In: Busse W.W., and Holgate S.T. (Eds). Asthma & rhinitis (2000), Blackwell Science, Oxford
2. Wanner A., Abraham W.M., Douglas J.S., Drazen J.M., Richerson H.B., and Sri Ram J. Models of airway hyperresponsiveness. Am Rev Respir Dis 141 (1990) 253-257
3. Abraham W.M., Delehunt J.C., Yerger L., and Marchette B. Characterization of a late phase pulmonary response following antigen challenge in allergic sheep. Am Rev Respir Dis 128 (1983) 839-844
4. Ahmed A., D'Brot J., Abraham W.M., Lucio J., Mendelssohn R., Robinson M.J., et al. Heterogeneity of allergic airway responses in sheep: differences in signal tranduction?. Am J Respir Crit Care Med 154 (1996) 843-849
5. Abraham W.M., Oliver Jr. W., King M.M., Yerger L., and Wanner A. Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep. Am Rev Respir Dis 124 (1981) 554-558
6. Sielczak M.W., Ahmed A., and Abraham W.M. Nedocromil sodium (NED) and methylprednisolone succinate (MPS) block bronchoalveolar lavage (BAL) eosinophilia produced by local bronchial antigen challenge in sheep. FASEB J 5 (1991) A1242
7. Signoretti F., Sielczak M.W., Ahmed A., Seybold Z., Stevenson J.S., and Abraham W.M. Lung inflammatory cell changes after local antigen-challenge in allergic sheep with and without late airway responses. FASEB J 2 (1988) A1185
8. Abraham W.M., Sielczak M.W., Wanner A., Perruchoud A.P., Blinder L., Stevenson J.S., et al. Cellular markers of inflammation in the airways of allergic sheep with and without allergen-induced late responses. Am Rev Respir Dis 138 (1988) 1565-1571
9. Soler M., Sielczak M., and Abraham W.M. Separation of late bronchial responses from airway hyperresponsiveness in allergic sheep. J Appl Physiol 70 (1991) 617-623
10. Soler M., Sielczak M.W., and Abraham W.M. A bradykinin-antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep. Pulm Pharmacol 3 (1990) 9-15
11. Soler M., Mansour E., Fernandez A., D'Brot J., Ahmed A., and Abraham W.M. PAF-induced airway responses in sheep: effects of a PAF-antagonist and nedocromil sodium. J Allergy Clin Immunol 85 (1990) 661-668
12. Abraham W.M. The sheep as a model of the late asthmatic response. In: Raeburn D., and Giembycz M.A. (Eds). Airways smooth muscle: modelling the asthmatic response in vivo (1996), Birkhauser Verlag, Basel
13. Abraham W.M. Sheep models of allergic bronchoconstriction. In: Kay A.B. (Ed). Allergy and allergic diseases (1997), Blackwell Science Ltd., Oxford
14. Hirsh A.J., Sabater J.R., Zamurs A., Smith R., Paradiso A., Hopkins S., et al. Evaluation of second generation amiloride analogues as therapy for CF lung disease. J Pharmacol Exp Ther 311 (2004) 929-938
15. Sabater J.R., Wanner A., and Abraham W.M. Montelukast prevents antigen-induced mucociliary dysfunction in sheep. Am J Respir Crit Care Med 166 (2002) 1457-1460
16. O'Riordan T.G., Otero R., Mao Y.M., Lauredo I., and Abraham W.M. Elastase contributes to antigen-induced mucociliary dysfunction in ovine airways. Am J Respir Crit Care Med 155 (1997) 1522-1528
17. Messina M.S., O'Riordan T.G., and Smaldone G.C. Changes in mucociliary clearance during acute exacerbations of asthma. Am Rev Respir Dis 143 (1991) 993-997
18. O'Riordan T.G., Zwang J., and Smaldone G.C. Mucociliary clearance in adult asthma. Am Rev Respir Dis 146 (1992) 598-603
19. 2 receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther 302 (2002) 871-880
20. Sabater J.R., Mao Y.M., Shaffer C., James M.K., O'Riordan T.G., and Abraham W.M. Aerosolization of P2Y(2)-receptor agonists enhances mucociliary clearance in sheep. J Appl Physiol 87 (1999) 2191-2196
21. Abraham W.M., Oliver Jr. W., Welker M.J., King M., Wanner A., and Sackner M.A. Differences in airway reactivity in normal and allergic sheep after exposure to sulfur dioxide. J Appl Physiol 51 (1981) 1651-1656
22. 4 on mucociliary and respiratory function in allergic and non-allergic sheep. J Appl Physiol 59 (1985) 1416-1422
23. 4 in allergic sheep with and without late bronchial responses. Prostaglandins 31 (1986) 445-455
24. 2 receptor stimulation. J Appl Physiol 72 (1992) 1831-1837
25. Abraham W.M., Baugh L.E., Harbeson S.L., Cortes A., and Ahmed A. Airway effects of inhaled bradykinin, substance P and neurokinin A in allergic sheep. Am Rev Respir Dis 139 4 (1989) A239
26. Delehunt J.C., Perruchoud A.P., Yerger L., Marchette B., Stevenson J.S., and Abraham W.M. The role of SRS-A in the late bronchial response following antigen challenge in allergic sheep. Am Rev Respir Dis 130 (1984) 748-754
27. Soler M., Sielczak M.W., and Abraham W.M. A PAF-antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep. J Appl Physiol 67 (1989) 406-413
28. 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest 93 (1994) 776-787
29. Durham S.R., Craddock C.F., Cookson W.O., and Benson M.K. Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses. J Allergy Clin Immunol 82 (1988) 764-770
30. Durham S.R., Graneek B.J., Hawkins R., and Taylor A.J.N. The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents. J Allergy Clin Immunol 79 (1987) 398-406
31. Cockroft D.W., and Murdock K.Y. Changes in bronchial responsiveness to histamine at intervals after allergen challenge. Thorax 42 (1987) 302
32. Abraham W.M., Gill A., Ahmed A., Sielczak M.W., Lauredo I.T., Botvinnikova Y., et al. A small-molecule, tight binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep. Am J Respir Crit Care Med 162 (2000) 603-611
33. Bischof R.J., Snibson K., Shaw R., and Meeusen E.N.T. Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite. Clin Exp Allergy 33 (2003) 367-375
34. Fujimoto K., Kubo K., Okada K., Kobayashi T., Sekiguchi M., and Sakai A. Effect of the 21-aminosteroid U-74006F on antigen-induced bronchoconstriction and bronchoalveolar esoinophilia in allergic sheep. Eur Respir J 9 (1996) 2044-2049
35. Liberman H., Mariassy A.T., Sorace D., Suster S., and Abraham W.M. Morphometric estimation of superoxide generation in allergen-induced airway hyperresponsiveness. Lab Invest 72 (1995) 348-354
36. Abraham W.M., Ahmed A., Sielczak M.W., Narita M., Arrhenius T., and Elices M.J. Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4. Am J Respir Crit Care Med 156 (1997) 696-703
37. Abraham W.M., Ahmed A., Sabater J.R., Lauredo I.T., Botvinnikova Y., Bjercke R.J., et al. Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep. Am J Respir Crit Care Med 159 (1999) 1205-1214
38. Rosen S.D., Tsay D., Singer M.S., Hemmerich S., and Abraham W.M. Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am J Pathol 166 (2005) 935-944
39. 4 integrins in the lung. In: Cytokines and adhesion molecules in the lung. Ann NY Acad Sci 796 (1996) 113-123
40. Abraham W.M., Ahmed A., Serebriakov I., Carmillo A.N., Ferrant J., de Fougerolles A.R., et al. A monoclonal antibody to α1β1 blocks antigen-induced airway responses in sheep. Am J Respir Crit Care Med 169 (2004) 97-104
41. Beeh K.M., Beier J., Buhl R., Zahlten R., and Wolff G. Influence of inhaled bimosiamose (TBC 1269), a synthetic pan-selectin antagonist, on the allergen-induced late asthmatic response (LAR) in patients with mild allergic asthma. Am J Respir Crit Care Med 169 (2004)
42. Toppila S., Paavonen T., Laitinen A., Laitinen L.A., and Renkonen R. Endothelial sulfated sialyl Lewis x glycans, putative L-selectin ligands, are preferentially expressed in bronchial asthma but not in other chronic inflammatory lung diseases. Am J Respir Cell Mol Biol 23 (2000) 492-498
43. Dyatkin A.B., Gong Y., Miskowski T.A., Kimball E.S., Prouty S.M., Fisher M.C., et al. Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists. Bioorg Med Chem 13 (2005) 6693-6702
44. 4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Clin Invest 100 (1997) 3083-3092
45. Abraham W.M., Ahmed A., Lauredo I.T., Botvinnikova Y., and Sielczak M.W. Chronic allergen challenge causes airway remodeling in sheep. Am J Respir Crit Care Med 163 (2001) A415
46. Snibson K.J., Bischof R.J., Slocombe R.F., and Meeusen E.N. Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite. Clin Exp Allergy 35 (2005) 146-152
47. Abraham W.M., Burch R.M., Farmer S.G., Sielczak M.W., Ahmed A., and Cortes A. A bradykinin antagonist modifies allergen-induced mediator release and late bronchial responses in sheep. Am Rev Respir Dis 143 (1991) 787-796
48. 4 in bronchoalveolar lavage fluid during biphasic allergic bronchoconstriction in sheep. Am Rev Respir Dis 139 (1989) 725-731
49. Clark J.M., Abraham W.M., Fishman C.E., Forteza R., Ahmed A., Cortes A., et al. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am J Respir Crit Care Med 152 (1995) 2076-2083
50. Dworski R., Sheller J.R., Wickersham N.E., Oates J.A., Brigham K.L., Roberts III L.J., et al. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid: effect of cyclooxygenase inhibition. Am Rev Respir Dis 139 (1989) 46-51
51. 4 in humans. Am Rev Respir Dis 141 (1990) 1441-1445
52. 4 excretion during antigen-induced bronchoconstriction in allergic sheep. J Appl Physiol 68 (1990) 1321-1327
53. Lanes S., Stevenson J.S., Codias E., Hernandez A., Sielczak M.W., and Abraham W.M. Effect of budesonide on late bronchial responses and the associated airway hyperresponsiveness in allergic sheep. In: Hogg J.C., Ellul-Micallef R., and Brattsand R. (Eds). Glucocorticosteroids inflammation and bronchial hyperreactivity (1985), Excerpta Medica
54. Delehunt J.C., Yerger L., Ahmed T., and Abraham W.M. Inhibition of antigen-induced bronchoconstriction by methylprednisolone succinate. J Allergy Clin Immunol 73 (1984) 479-483
55. Lanes S., Stevenson J.S., Codias E., Hernandez A., Sielczak M.W., Wanner A., et al. Indomethacin and FPL-57231 inhibit antigen-induced airway hyperresponsiveness in sheep. J Appl Physiol 61 (1986) 864-872
56. Kirby J.G., Hargreave F.E., Cockcroft D.W., and O'Byrne P.M. The effect of indomethacin on allergen-induced asthmatic responses. J Appl Physiol 66 (1989) 578-583
57. Wright C.D., Havill A.M., Middleton S.C., Kashem M.A., Dripps D.J., Abraham W.M., et al. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-{4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]phenoxy}-pentane (AMG-126737). Biochem Pharmacol 58 (1999) 1989-1996
58. Krishna M.T., Chauhan A., Little L., Sampson K., Hawksworth R., Mant T., et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol 107 (2001) 1039-1045
59. Christiansen S.C., Proud D., and Cochrane C.G. Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects. J Clin Invest 79 (1987) 188-197
60. Christiansen S.C., Zuraw B.L., Proud D., and Cochrane C.G. Inhibition of human bronchial kallikrein in asthma. Am Rev Respir Dis 139 (1989) 1125-1131
61. Christiansen S.C., Proud D., Sarnoff R.B., Juergens U., Cochrane C.G., and Zuraw B.L. Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge. Am Rev Respir Dis 145 (1992) 900-905
62. 1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness. Am J Respir Crit Care Med 154 (1996) 36-42
63. 1-proteinase inhibitor blocks antigen- and mediator-induced airway responses in sheep. J Appl Physiol 93 (2002) 1900-1906
64. 1-protease inhibitor (Prolastin) affects basal airway responsiveness in mild asthmatics. Am J Respir Crit Care Med 159 (1999) A624
65. Groneberg D.A., Eynott P.R., Lim S., Oates T., Wu R., Carlstedt I., et al. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 40 (2002) 367-373
66. Allegra L., Abraham W.M., Chapman G.A., and Wanner A. Duration of mucociliary dysfunction following antigen challenge. J Appl Physiol 55 (1983) 726-730
67. Wanner A., Salathé M., and O'Riordan T.G. Mucociliary clearance in the airways. Am J Respir Crit Care Med 154 (1996) 1868-1902
68. Mezey R.J., Cohen M.A., Fernandez R.J., Januszkiewicz A.J., and Wanner A. Mucociliary transport in allergic patients with antigen-induced bronchospasm. Am Rev Respir Dis 118 (1978) 677-684
69. O'Riordan T.G., Mao Y., Otero R., Lopez J., Sabater J.R., and Abraham W.M. Budesonide affects allergic mucociliary dysfunction. J Appl Physiol 85 (1998) 1086-1091
70. Abraham W.M., Ahmed A., Cortes A., Sielczak M., and Hallmon J. The effects of cysteinyl leukotriene antagonist (ONO-1078) on antigen induced responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids 48 (1993) 233-239
71. 4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins 31 (1986) 457-467
72. Abraham W.M., Ahmed A., Cortes A., Sielczak M., and Hallmon J. The effects of a cysteinyl leukotriene antagonist (ONO-1078) on antigen-induced responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids 48 (1993) 233-239
73. Mellor E.A., Maekawa A., Austen K.F., and Boyce J.A. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci USA 98 (2001) 7964-7969
74. Abraham W.M., Ahmed A., Ahmed T., Atkins N., and Andersson P. Pharmacologic evaluation of an allergic rhinitis model. Am J Respir Crit Care Med 153 (1998) A616
75. Lambrou P., Botvinnikova Y., Ahmed A., and Abraham W.M. Early and late mediator and cellular responses after nasal allergen provocation in the sheep model of allergic rhinitis. Am J Respir Crit Care Med 161 (2000) A324
76. Jones T.R., Savoie C., Robichaud A., Sturino C., Scheigetz J., Lachance N., et al. Studies with a DP receptor antagonist in sheep and guinea pig models of allergic rhinitis. Am J Respir Crit Care Med 167 (2003) A218
77. Sabater J.R., Lee T.A., and Abraham W.M. Comparative effects of salmeterol, albuterol, and ipratropium on normal and impaired mucociliary function in sheep. Chest 128 (2005) 3743-3749
78. Hill A.T., Bayley D., and Stockley R.A. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med 160 (1999) 893-898
79. Jatakanon A., Uasuf C., Maziak W., Lim S., Chung K.F., and Barnes P.J. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 160 (1999) 1532-1539
80. Little S.A., Macleod K.J., Chalmers G.W., Love J.G., McSharry C., and Thomson N.C. Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. Am J Med 112 (2002) 446-452
81. Conese M., Copreni E., Di Gioia S., De Rinaldis P., and Fumarulo R. Neutrophil recruitment and airway epithelial cell involvement in chronic cystic fibrosis lung disease. J Cyst Fibros 2 (2003) 129-135
82. Qiu Y., Zhu J., Bandi V., Atmar R.L., Hattotuwa K., Guntupalli K.K., et al. Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 168 (2003) 968-975