Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 3, 2014, Pages 1479-1487

  Zhao, Fei ^a,b   Wang, Xu De ^a   Erber, Luke N ^c   Luo, Ming ^d   Guo, Ai Zhen ^b   Yang, Shan Shan ^a   Gu, Jing ^a   Turman, Breanna J ^c   Gao, Yun Rong ^e   Li, Dong Fang ^f,g   Cui, Zong Qiang ^a   Zhang, Zhi Ping ^a   Bi, Li Jun ^e   Baughn, Anthony D ^c   Zhang, Xian En ^e   Deng, Jiao Yu ^a  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF MINNESOTA   (United States)

^d Chongqing Institution of Tuberculosis Prevention and Treatment   (China)

^e INSTITUTE OF BIOPHYSICS   (China)

^f Shenzhen Key Laboratory of Unknown Pathogen Identification   (China)

^g BGI Tianjin   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE SYNTHETASE; DIHYDROFOLIC ACID; SYNTHETASE; UNCLASSIFIED DRUG;

ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CODING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; FOLATE METABOLISM; FOLC GENE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MISSENSE MUTATION; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALLELES; AMINOSALICYLIC ACID; ANTI-BACTERIAL AGENTS; BINDING SITES; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES;

EID: 84896890581     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01775-13     Document Type: Article

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