Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease

Archives of Medical Research

Volumn 45, Issue 2, 2014, Pages 116-124

  Stanković, Milena N ^a   Mladenović, Dušan R ^a   Duričić, Ivana ^a   Šobajić, Sladana S ^a   Timić, Jasmina ^a   Jorgačević, Bojan ^a   Aleksić, Vuk ^a   Vučević, Danijela B ^a   Ješić Vukićević, Rada ^b   Radosavljević, Tatjana S ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Free fatty acids; Lipid status; Methionine choline deficient diet; Mice; NAFLD

Indexed keywords

ALANINE AMINOTRANSFERASE; ARACHIDONIC ACID; ASPARTATE AMINOTRANSFERASE; CHOLINE; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN; METHIONINE; OLEIC ACID; SATURATED FATTY ACID; STEARIC ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; DISEASE ASSOCIATION; DISEASE COURSE; FATTY ACID ANALYSIS; GAS CHROMATOGRAPHY; HISTOPATHOLOGY; LIPID BLOOD LEVEL; LIVER STRUCTURE; LIVER WEIGHT; MALE; METHIONINE CHOLINE DEFICIENT; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

FREE FATTY ACIDS; LIPID STATUS; METHIONINE-CHOLINE DEFICIENT DIET; MICE; NAFLD;

ANIMALS; CHOLINE; DIET; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; HEPATOCYTES; LIPIDS; LIVER; MALE; METHIONINE; MICE, INBRED C57BL; RISK FACTORS; TIME FACTORS;

EID: 84896879418     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2013.12.010     Document Type: Article

References (35)

1. Ertle J., Dechêne A., Sowa J.P., et al. Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis. Int J Cancer 2011, 128:2436-2443.
2. Nagata K., Suzuki H., Sakaguchi S. Common pathogenic mechanisms in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci 2007, 32:453-468.
3. Tarantino G. Non-alcoholic fatty liver disease, obesity and other illnesses. Clin Invest Med 2008, 31:E290-E295.
4. Tarantno G., Savastano S., Coalo A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol 2010, 16:4773-4783.
5. Takahashi Y., Soejima Y., Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 2012, 18:2300-2308.
6. Marcolin E., Forgiarini L.F., Tieppo J., et al. Methionine- and choline deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis. Arq Gastroenterol 2011, 48:72-79.
7. Allain C.C., Poon L.S., Richmond W. Plasma lipid determination. Clin Chem 1974, 20:470-475.
8. Friedewald W.T., Levy R.I., Frederickson D.S. Estimation of the concentration of LDL cholesterol in plasma, without use of the centrifuge. Clin Chem 1972, 18:499-502.
9. Trinder P. PAP method. Ann Clin Biochem 1983, 6:485.
10. Bligh E.C., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:913-917.
11. Ichihara K., Fukubayashi K. Preparation of fatty acid methyl esters for gas-liquid chromatography. J Lipid Res 2010, 51:635-640.
12. Takayama F., Egashira T., Kawasaki H., et al. A novel animal model of nonalcoholic steatohepatitis (NASH): hypoxemia enhances the development of NASH. J Clin Biochem Nutr 2009, 45:335-340.
13. Zou Y., Li J., Lu C., et al. High-fat emulsion-induces rat model of nonalcoholic steatohepatitis. Life Sci 2006, 79:1100-1107.
14. Rinella M.E., Green R.M. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 2004, 40:47-51.
15. Knebel B., Haas J., Hartwig S., et al. Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass. PLoS ONE 2012, 7:e31812. doi:10.1371.
16. Park H.S., Jeon B.H., Woo S.H., et al. Time-dependent changes in lipid metabolism in mice with methionine-choline deficiency-induced fatty liver disease. Mol Cells 2011, 32:571-577.
17. Vial G., Dubouchaud H., Couturier K., et al. Effects of a high-fat diet on energy metabolism and ROS production in rat liver. J Hepatol 2011, 54:348-356.
18. Treeprasertsuk S., Lopez-Jimenez F., Lindor K.D. Nonalcoholic fatty liver disease and the coronary artery disease. Dig Dis Sci 2011, 56:35-45.
19. Fan C.Y., Pan J., Usuda N., et al. Steatohepatitis, spontaneous peroxisome proliferation and liver tumours in mice lacking peroxisomal fatty acyl-CoA oxidase. J Biol Chem 1998, 273:639-645.
20. Bradbury M.W. Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 2006, 290:G194-G198.
21. Tang X., Li J., Xu J., et al. Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. Lipids Health Dis 2012, 11:70.
22. Puri P., Baillie R.A., Wiest M.M., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
23. Donnelly K.L., Smith C.I., Schwarzenberg S.J., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
24. Malhi H., Gores G.J. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 2008, 28:360-369.
25. De Almeida I.T., Cortez-Pinto H., Fidalgo G., et al. Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin Nutr 2002, 21:219-223.
26. Chavez-Tapia N.C., Rosso N., Tiribelli C. Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease. BMC Gastroenterol 2012, 12:20.
27. Tarantino G., Conca P., Pasanisi F., et al. Could inflammatory markers help diagnose nonalcoholic steatohepatitis?. Eur J Gastroenterol Hepatol 2009, 2:504-511.
28. Wieckowska A., Papouchado B.G., Li Z., et al. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol 2008, 103:1372-1379.
29. Tarantino G., Conca P., Riccio A., et al. Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?. J Transl Med 2008, 6:72.
30. Garneau V., Rudkowska I., Paradis A.M., et al. Association between plasma omega-3 fatty acids and cardiovascular disease risk factors. Appl Physiol Nutr Metab 2013, 38:243-248.
31. Frohnert B.I., Jacobs D.R., Steinberger J., et al. Relation between serum free fatty acids and adiposity, insulin resistance and cardiovascular risk factors from adolescence to adulthood. Diabetes 2013, May 13 [Epub ahead of print].
32. Wang S., Matthan N.R., Wu D., et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. ClinNutr 2013, pii: S0261-5614(13)00109-X [Epub ahead of print]. 10.1016/j.clnu.2013.04.009.
33. Ottestad I., Hassani S., Borge G.I., et al. Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS One 2012, 7:e42550.
34. Tarantino G., Scopacasa F., Colao A., et al. Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease. World J Gastroenterol 2011, 17:5280-5288.
35. Ribeiro P.S., Cortez-Pinto H., Sola S., et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004, 99:1708-1717.