Pien Tze Huang inhibits hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells through suppression of the HIF-1 pathway

Experimental and Therapeutic Medicine

Volumn 7, Issue 5, 2014, Pages 1237-1242

  Chen, Hongwei ^a   Shen, Aling ^a   Zhang, Yuchen ^a   Chen, Youqin ^b   Lin, Jiumao ^a   Lin, Wei ^a   Sferra, Thomas ^b   Peng, Jun ^a,c  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Zhangzhou Pien Tze Huang Pharmaceutical Co Ltd   (China)

Author keywords

Colon cancer; Epithelial mesenchymal transition; HIF 1 pathway; Hypoxia; Pien Tze Huang; Traditional Chinese medicine

Indexed keywords

CHINESE DRUG; HYPOXIA INDUCIBLE FACTOR 1; NERVE CELL ADHESION MOLECULE; PIEN TZE HUANG; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL INVASION ASSAY; CELL MIGRATION; CELL STRUCTURE; COLON CARCINOMA; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HYPOXIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84896866849     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1549     Document Type: Article

References (31)

1. 2histography. Antioxid Redox Signal9: 1221-1235, 2007.
2. Höckel M and Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276, 2001.
3. Guillemin K and Krasnow MA: The hypoxic response: huffing and HIFing. Cell 89: 9-12, 1997.
4. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
5. Poon E, Harris AL and Ashcroft M: Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev Mol Med 11: e26, 2009.
6. 2tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
7. Schofield CJ and Ratcliffe PJ: Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5: 343-354, 2004.
8. 2homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578, 1999.
9. Jiang BH, Rue E, Wang GL, Roe R and Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996.
10. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
11. 2sensing. Science 292: 464-468, 2001.
12. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER and Ratcliffe PJ: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
13. Semenza GL: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3, 2001.
14. Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, TanakaH and Poellinger L: Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 17: 6573-6586, 1998.
15. Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ and van der Wall E: Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 93: 309-314, 2001.
16. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and SimonsJW: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.
17. Cheng ZX, Sun B, Wang SJ, Gao Y, Zhang YM, Zhou HX, JiaG, Wang YW, Kong R, Pan SH, Xue DB, Jiang HC and BaiXW: Nuclear Factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions. PLoS One 6: e23752, 2011.
18. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006.
19. Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
20. Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
21. Turley EA, Veiseh M, Radisky DC and Bissell MJ: Mechanisms of disease: epithelial-mesenchymal transition-does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 5: 280-290, 2008.
22. Bates RC and Mercurio A: The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther 4: 365-370, 2005.
23. Gordaliza M: Natural products as leads to anticancer drugs. Clin Transl Oncol 9: 767-776, 2007.
24. Ji HF, Li XJ and Zhang HY: Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep 10: 194-200, 2009.
25. Chinese Pharmacopoeia Commission: Pharmacopoeia of the People's Republic of China. Vol 1. Chinese Medical Science and Technology Press, Beijing, pp573-575, 2010.
26. Lin JM, Wei LH, Chen YQ, Liu XX, Hong ZF, Sferra TJ and Peng J: Pien Tze Huang induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3. Chin J Integr Med 17: 685-690, 2011
27. Zhuang Q, Hong F, Shen A, Zheng L, Zeng J, Lin W, Chen Y, Sferra T, Hong Z and Peng J: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol 40: 1569-1574, 2012.
28. Shen AL, Hong F, Liu LY, Lin JM, Zhuang QC, Hong ZF and Peng J: Effects of Pien Tze Huang on angiogenesis in vivo and in vitro. Chin J Integr Med 18: 431-436, 2012.
29. 1/S cell cycle progression. Oncol Lett 4: 767-770, 2012.
30. Shen A, Chen Y, Hong F, Lin J, Wei L, Hong Z, Sferra TJ and Peng J: Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep 28: 2125-2130, 2012.
31. Shen A, Lin J, Chen Y, Lin W, Liu L, Hong ZF Sferra TJ and Peng J: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways. Oncol Rep 30: 1701-1706, 2013.