메뉴 건너뛰기




Volumn 28, Issue 6, 2012, Pages 2125-2130

Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3

Author keywords

Colorectal cancer; IL 6 STAT3 pathway; Pien Tze Huang; SOCS3; Traditional Chinese medicine

Indexed keywords

CHINESE DRUG; CYCLIN D; INTERLEUKIN 6; PIEN TZE HUANG; PROTEIN BCL 2; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

EID: 84868096612     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2067     Document Type: Conference Paper
Times cited : (39)

References (40)
  • 2
    • 0034106055 scopus 로고    scopus 로고
    • Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
    • Belluco C, Nitti D, Frantz M, Toppan P, Basso D, Plebani M, Lise M and Jessup JM: Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer. Ann Surg Oncol 7:133-138, 2000. (Pubitemid 30164682)
    • (2000) Annals of Surgical Oncology , vol.7 , Issue.2 , pp. 133-138
    • Belluco, C.1    Nitti, D.2    Frantz, M.3    Toppan, P.4    Basso, D.5    Plebani, M.6    Lise, M.7    Jessup, J.M.8
  • 5
    • 0034599429 scopus 로고    scopus 로고
    • Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells
    • DOI 10.1016/S0304-3835(99)00401-2, PII S0304383599004012
    • Schneider MR, Hoeflich A, Fischer JR, Wolf E, Sordat B and Lahm H: Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. Cancer Lett 151:31-38, 2000. (Pubitemid 30155582)
    • (2000) Cancer Letters , vol.151 , Issue.1 , pp. 31-38
    • Schneider, M.R.1    Hoeflich, A.2    Fischer, J.R.3    Wolf, E.4    Sordat, B.5    Lahm, H.6
  • 8
    • 0036399699 scopus 로고    scopus 로고
    • Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: A mechanism for metastatic initiation?
    • Dowdall JF, Winter DC, Andrews E, Laug WE, Wang JH and Redmond HP: Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation? J Surg Res 107:1-6, 2002. (Pubitemid 35191805)
    • (2002) Journal of Surgical Research , vol.107 , Issue.1 , pp. 1-6
    • Dowdall, J.F.1    Winter, D.C.2    Andrews, E.3    Laug, W.E.4    Wang, J.H.5    Redmond, H.P.6
  • 10
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J and Darnell JE Jr: The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19:2468-2473, 2000. (Pubitemid 30339202)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 12
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • DOI 10.1126/science.277.5332.1630
    • Darnell JE Jr: STATs and gene regulation. Science 277:1630-1635, 1997. (Pubitemid 27446219)
    • (1997) Science , vol.277 , Issue.5332 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 14
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S and Weinstein IB: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62:3351-3355, 2002. (Pubitemid 34651376)
    • (2002) Cancer Research , vol.62 , Issue.12 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6    Tomita, K.7    Komiyama, S.8    Weinstein, I.B.9
  • 15
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • Bromberg J and Wang TC: Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 15:79-80, 2009.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 18
    • 40149094813 scopus 로고    scopus 로고
    • Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
    • DOI 10.1593/neo.07971
    • Xiong H, Zhang Z, Tian X, Sun D, Liang Q, Zhang Y, Lu R, Chen Y and Fang J: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 10:287-297, 2008. (Pubitemid 351328587)
    • (2008) Neoplasia , vol.10 , Issue.3 , pp. 287-297
    • Xiong, H.1    Zhang, Z.-G.2    Tian, X.-Q.3    Sun, D.-F.4    Liang, Q.-C.5    Zhang, Y.-J.6    Lu, R.7    Chen, Y.-X.8    Fang, J.-Y.9
  • 26
    • 34447629700 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon
    • DOI 10.1038/sj.onc.1210286, PII 1210286
    • Rigby RJ, Simmons JG, Greenhalgh CJ, Alexander WS and Lund PK: Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 26:4833-4841, 2007. (Pubitemid 47093177)
    • (2007) Oncogene , vol.26 , Issue.33 , pp. 4833-4841
    • Rigby, R.J.1    Simmons, J.G.2    Greenhalgh, C.J.3    Alexander, W.S.4    Lund, P.K.5
  • 27
    • 0036955756 scopus 로고    scopus 로고
    • Chemoprevention of colon cancer: Current status and future prospects
    • DOI 10.1023/A:1021271229476
    • Gustin DM and Brenner DE: Chemoprevention of colon cancer: current status and future prospects. Cancer Metastasis Rev 21:323-348, 2002. (Pubitemid 36071919)
    • (2002) Cancer and Metastasis Reviews , vol.21 , Issue.3-4 , pp. 323-348
    • Gustin, D.M.1    Brenner, D.E.2
  • 28
    • 0033400231 scopus 로고    scopus 로고
    • Drug resistance in colon cancer
    • Gorlick R and Bertino JR: Drug resistance in colon cancer. Semin Oncol 26:606-611, 1999. (Pubitemid 30013267)
    • (1999) Seminars in Oncology , vol.26 , Issue.6 , pp. 606-611
    • Gorlick, R.1    Bertino, J.R.2
  • 29
    • 33847244929 scopus 로고    scopus 로고
    • Drug resistance, predictive markers and pharmacogenomics in colorectal cancer
    • Longley DB, Allen WL and Johnston PG: Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta 1766:184-196, 2006.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 184-196
    • Longley, D.B.1    Allen, W.L.2    Johnston, P.G.3
  • 30
    • 0033922361 scopus 로고    scopus 로고
    • Genotoxicity of several clinically used topoisomerase II inhibitors
    • DOI 10.1016/S0378-4274(00)00192-2, PII S0378427400001922
    • Boose G and Stopper H: Genotoxicity of several clinically used topoisomerase II inhibitors. Toxicol Lett 116:7-16, 2000. (Pubitemid 30440762)
    • (2000) Toxicology Letters , vol.116 , Issue.1-2 , pp. 7-16
    • Boos, G.1    Stopper, H.2
  • 31
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • DOI 10.1039/a902202c
    • Newman DJ, Cragg GM and Snader KM: The influence of natural products upon drug discovery. Nat Prod Rep 17:215-234, 2000. (Pubitemid 30390787)
    • (2000) Natural Product Reports , vol.17 , Issue.3 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 32
    • 39149098194 scopus 로고    scopus 로고
    • Natural products as leads to anticancer drugs
    • Gordaliza M: Natural products as leads to anticancer drugs. Clin Transl Oncol 9:767-776, 2007.
    • (2007) Clin Transl Oncol , vol.9 , pp. 767-776
    • Gordaliza, M.1
  • 33
    • 77957873646 scopus 로고    scopus 로고
    • Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells
    • Lin JM, Chen YQ, Wei LH, Chen XZ, Xu W, Hong ZF, Sferra TJ and Peng J: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol 37:1331-1338, 2010.
    • (2010) Int J Oncol , vol.37 , pp. 1331-1338
    • Lin, J.M.1    Chen, Y.Q.2    Wei, L.H.3    Chen, X.Z.4    Xu, W.5    Hong, Z.F.6    Sferra, T.J.7    Peng, J.8
  • 35
    • 84860284495 scopus 로고
    • Clinical analysis of the effect of Pien Tze Huang in treatment of 42 patients with moderate or advanced liver cancer
    • Xu YY and Yu EX: Clinical analysis of the effect of Pien Tze Huang in treatment of 42 patients with moderate or advanced liver cancer. Shanghai J Tradit Chin Med 12:4-5, 1994.
    • (1994) Shanghai J Tradit Chin Med , vol.12 , pp. 4-5
    • Xu, Y.Y.1    Yu, E.X.2
  • 36
    • 84860280251 scopus 로고
    • Therapeutical observation of advanced colon cancer
    • Gu ZX: Therapeutical observation of advanced colon cancer. Chin Tradit Patent Med 15:23, 1993.
    • (1993) Chin Tradit Patent Med , vol.15 , pp. 23
    • Gu, Z.X.1
  • 37
    • 84862832921 scopus 로고    scopus 로고
    • Pien Tze Huang-induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3
    • Lin JM, Wei LH, Chen YQ, Liu XX, Hong ZF, Sferra TJ and Peng J: Pien Tze Huang-induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3. Chin J Integr Med 17:685-690, 2011.
    • (2011) Chin J Integr Med , vol.17 , pp. 685-690
    • Lin, J.M.1    Wei, L.H.2    Chen, Y.Q.3    Liu, X.X.4    Hong, Z.F.5    Sferra, T.J.6    Peng, J.7
  • 38
    • 84860307864 scopus 로고    scopus 로고
    • Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model
    • Zhuang QC, Hong F, Shen AL, Zheng LP, Zeng JW, Lin W, Chen YQ, Sferra TJ, Hong ZF and Peng J: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol 40:1569-1574, 2012.
    • (2012) Int J Oncol , vol.40 , pp. 1569-1574
    • Zhuang, Q.C.1    Hong, F.2    Shen, A.L.3    Zheng, L.P.4    Zeng, J.W.5    Lin, W.6    Chen, Y.Q.7    Sferra, T.J.8    Hong, Z.F.9    Peng, J.10
  • 39
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • DOI 10.1074/jbc.275.17.12848
    • Schmitz J, Weissenbach M, Haan S, Heinrich PC and Schaper F: SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275:12848-12856, 2000. (Pubitemid 30241440)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.17 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.