Design, synthesis, and in vitro biological evaluation of 1 H -1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2144-2153

  Cheng, Huimin ^a,d   Wan, Junting ^a   Lin, Meng I ^b   Liu, Yingxue ^a   Lu, Xiaoyun ^a   Liu, Jinsong ^a   Xu, Yong ^a   Chen, Jianxin ^c   Tu, Zhengchao ^a   Cheng, Yih Shyun E ^b   Ding, Ke ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(4 (2 CHLORO 4 NITROPHENYL)PIPERAZIN 1 YL)(1 (2 METHOXYPHENYL) 4 METHYL 1H 1,2,3 TRIAZOL 5 YL)METHANONE; 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE DERIVATIVE; INFLUENZA VACCINE; OSELTAMIVIR; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFLUENZA A; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; NONHUMAN; PARTIAL DRUG SYNTHESIS; VIRUS STRAIN;

AMANTADINE; AMIDES; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; DRUG DESIGN; DRUG RESISTANCE, VIRAL; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; MODELS, MOLECULAR; NUCLEOPROTEINS; OSELTAMIVIR; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VIRAL CORE PROTEINS; VIRAL PLAQUE ASSAY; VIRUS REPLICATION;

EID: 84863232815     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2013503     Document Type: Article

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