HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3032-3037

  Rotblat, Barak ^a,b   Southwell, Amber L ^c   Ehrnhoefer, Dagmar E ^c   Skotte, Niels H ^c   Metzler, Martina ^c   Franciosi, Sonia ^c   Leprivier, Gabriel ^a   Somasekharan, Syam Prakash ^a   Barokas, Adi ^a   Deng, Yu ^c   Tang, Tiffany ^a   Mathers, Joan ^a   Cetinbas, Naniye ^a   Daugaard, Mads ^a   Kwok, Brian ^a   Li, Liheng ^a   Carnie, Christopher J ^a   Fink, Dieter ^a   Nitsch, Roberto ^d   Galpin, Jason D ^e   Ahern, Christopher A ^e   Melino, Gerry ^b,f   Penninger, Josef M ^d   Hayden, Michael R ^c   Sorensen, Poul H ^a   more..

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Aging; Glutathione; ROS; Transcription factor

Indexed keywords

HUNTINGTIN; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; CORPUS STRIATUM; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; HYPERSENSITIVITY; MOUSE; MUTANT; NEURAL STEM CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REGULATORY MECHANISM; WILD TYPE;

AGING; GLUTATHIONE; ROS; TRANSCRIPTION FACTOR;

ANIMALS; BLOTTING, WESTERN; CELL FRACTIONATION; CORPUS STRIATUM; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; MICE; NERVE TISSUE PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84896834601     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314421111     Document Type: Article

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