Biological evaluation of isoniazid derivatives as an anticancer class

Scientia Pharmaceutica

Volumn 82, Issue 1, 2014, Pages 21-28

  Rodrigues, Felipe A R ^a   Oliveira, Augusto C A ^a   Cavalcanti, Bruno C ^a   Pessoa, Claudia ^a   Pinheiro, Alessandra C ^b   De Souza, Marcus V N ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antitumor activity; Cytotoxicity; Drugs; Hydrazone; Isoniazid

Indexed keywords

DOXORUBICIN; ISONIAZID DERIVATIVE; PYRAZINAMIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MTT ASSAY; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION;

EID: 84896834086     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1307-25     Document Type: Article

References (24)

1. Grozinger KG, Fuchs V, Hargrave KD, Mauldin S, Vitous J, Campbell S, Adams J. Synthesis of nevirapine and its major metabolite. J Heterocycl Chem. 1995; 32: 259-263. http://dx.doi.org/10.1002/jhet.5570320144/
2. Hankes LV. In: Handbook of vitamins, nutritional, biochemical and clinical aspects. Marcel Dekker: New York, 1984; pp.329-377.
3. Arigon J, Bernhart C, Bouaboula M, Casellas P, Combet R, Jegham S, Hllalret S, Fraisse P. Nicotinamide derivatives, preparation thereof and therapeutic use thereof. WO 2009074749A2, 2009.
4. Aanandhi MV, Mansoori MH, Shanmugapriya S, George S, Shanmugasundaram P. Synthesis and in vitro antioxidant activity of substituted pyridinyl 1,3,4 oxadiazole derivatives. Res J Pharm Biol Chem Sci. 2010; 1: 1083-1090.
5. Kheradmand A, Navidpour L, Shafaroodi H, Saeedi-Motahar G, Shafiee A. Design and synthesis of niflumic acid-based-acylhydrazone derivatives as novel anti-inflammatory and analgesic agents. Med Chem Res. 2013; 22: 2411-2420. http://dx.doi.org/10.1007/s00044-012-0235-3/
6. De Souza MVN, Fernandes EL, Pais KC, Vasconcelos TA, Wardell SMSV, Wardell JL. Cyclisation of 2-chloro-N-(methyl-2-pyridinyl)nicotinamides to methyl 5-oxo-5,6-dihydro- dipyrido [1,2-a:3',2'-e]pyrimidin-11-ium chlorides. J Chem Res. 2006; 2: 93-97. http://dx.doi.org/10.3184/030823406776331007/
7. De Souza MVN. Current Status and future prospects for new therapies for pulmonary tuberculosis. Curr Opin Pulm Med. 2006; 12: 167-171. http://dx.doi.org/10.1097/01.mcp.0000219264.42686.c9/
8. De Souza MVN, Ferreira ML, Pinheiro AC, Saraiva MF, Almeida MV, Valle MS. Synthesis and Biological Aspects of Mycolic Acids: An Important Target Against Mycobacterium tuberculosis. ScientificWorldJournal. 2008; 8: 720-751. http://dx.doi.org/10.1100/tsw.2008.99/
9. Black M, Hussain H. Hydrazine, Cancer, the Internet, Isoniazid, and the Liver. Ann Intern Med. 2000; 133: 911-913. http://dx.doi.org/10.7326/0003-4819-133-11-200012050-00016/
10. Kumar H, Malhotra D, Sharma R, Sausville E, Malhotra M. Synthesis, characterization and evaluation of Isoniazid analogues as potent anticancer agents. Pharmacologyonline. 2011; 3: 337-343.
11. American Cancer Society. Country. http://www.cancer.org/ (Accessed July, 2013)
12. World Health Organization. Country urlhttp://www.who.int/gho/ncd/mortality_morbidity/cancer/en/index.html (Accessed July, 2013)
13. Ma D, Chan DS, Leung C. Drug repositioning by structure-based virtual screening. Chem Soc Rev. 2013: 42: 2130-2141. http://dx.doi.org/10.1039/c2cs35357a/
14. Liu Z, Fang H, Reagan K, Xu X, Mendrick DL, Slikker Jr W, Tong W. In silico drug repositioning - what we need to know. Drug Discov Today. 2013; 18: 110-115. http://dx.doi.org/10.1016/j.drudis.2012.08.005/
15. De Souza MVN, Vasconcelos TA, Mello SCP, Wardell SMSV, Peralta MA, Ferreira B, Henriques MGMO, Neves Jr I, Lourenço MCS. Synthesis and Anti-Mycobacterial Activity of N'-[(E)-(Disubstituted-Phenyl)Methylidene] IsonicotinoHydrazide Derivatives. Lett Drug Des Discov. 2005; 2: 563-566. http://dx.doi.org/10.2174/157018005774479131/
16. De Souza MVN, Neves Jr I, Miranda GBP, Lourenço MCS, Vasconcelos TA, Pais KC, Wardell JL, Wardell SMSV, Alcântara Jr JP. Synthesis and in vitro anti-tubercular activity of a series of N'(disubstitutedbenzoyl) Isoniazid derivatives. Lett Drug Des Discov. 2006; 3: 424-428. http://dx.doi.org/10.2174/157018006777805549/
17. Ferreira ML, Cardoso LNF, Gonçalves RSB, Silva ET, Lourenço MCS, De Souza MVN. Synthesis and antitubercular evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) methylidene]isonicotinohydrazide derivatives. Lett Drug Des Discov. 2008; 5: 137-140. http://dx.doi.org/10.2174/157018008783928472/
18. Lourenço MCS, De Souza MVN, Pinheiro AC, Ferreira ML, Goncalves RSB, Nogueira TCM, Peralta MA. Evaluation of anti-tubercular activity of nicotinic and Isoniazid analogues. Arkivoc. 2007; 15: 181-191. http://dx.doi.org/10.3998/ark.5550190.0008.f18/
19. Carvalho SA, Da Silva EF, De Souza MVN, Lourenço MCS, Vicente FRC. Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives. Bioorg Med Chem Lett. 2008; 18: 538-541. http://dx.doi.org/10.1016/j.bmcl.2007.11.091/
20. Lima CHS, Henriques MGMO, Candéa ALP, Lourenço MCS, Bezerra FAFM, Kaiser CR, De Souza MVN. Antimycobacterial evaluation of N'-(E)-heteroaromatic pyrazine-2-carbohydrazide derivatives. Med Chem (Hilversum). 2011; 7: 245-249. http://dx.doi.org/10.2174/157340611795564303/
21. Narang R, Narasimhan B, Sharma S. A review on biological activities and chemical synthesis of hydrazide derivatives. Curr Med Chem. 2012; 19: 569-612. http://dx.doi.org/10.2174/092986712798918789/
22. Rollas S, Küçükgüzel SG. Biological activities of hydrazones derivatives. Molecules. 2007; 12: 1910-1939. http://dx.doi.org/10.3390/12081910/
23. Vergara FMF, Da Silva CHL, Henriques MGMO, Candéa ALP, Lourenço MCS, Ferreira ML, Kaiser CR, De Souza MVN. Synthesis and antimycobacterial activity of N'-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives. Eur J Med Chem. 2009; 44: 4954-4959. http://dx.doi.org/10.1016/j.ejmech.2009.08.009/
24. Mosmann TJ. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth. 1983; 65: 55-63. http://dx.doi.org/10.1016/0022-1759(83)90303-4/