메뉴 건너뛰기




Volumn 12, Issue 3, 2014, Pages 359-371

Critical review of non-statin treatments for dyslipoproteinemia

Author keywords

dyslipidemia; familial combined hyperlipidemia; familial hypercholesterolemia; hypertriglyceridemia; lipoprotein(a); metabolic syndrome; new therapy; statin intolerance; treatment; Type 2 diabetes

Indexed keywords

ANGIOPOIETIN LIKE PROTEIN INHIBITOR; ANTISENSE OLIGONUCLEOTIDE; BILE ACID SEQUESTRANT; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; EZETIMIBE; FARNESOID X RECEPTOR; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INCRETIN; LIPOPROTEIN A; LOMITAPIDE; LOW DENSITY LIPOPROTEIN; MIPOMERSEN; NICOTINIC ACID; NUTRACEUTICAL; OBETICHOLIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84896768836     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2014.888312     Document Type: Review
Times cited : (6)

References (206)
  • 1
    • 84855185039 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2012
    • American Diabetes Association.
    • American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35(Suppl 1):S11-63
    • (2012) Diabetes Care , vol.35 , Issue.SUPPL. 1
  • 2
    • 84885997413 scopus 로고    scopus 로고
    • ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
    • Rydén L, Grant PJ, Anker SD, et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 2013;34(39):3035-87
    • (2013) Eur Heart J , vol.34 , Issue.39 , pp. 3035-3087
    • Rydén, L.1    Grant, P.J.2    Anker, S.D.3
  • 3
    • 79953836812 scopus 로고    scopus 로고
    • Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol< 50 mg/dl with rosuvastatinthe JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)
    • Hsia J, MacFadyen JG, Monyak J, Ridker PM. Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol < 50 mg/dl with rosuvastatinthe JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). J Am Coll Cardiol 2011; 57(16): 1666-75
    • (2011) J Am Coll Cardiol , vol.57 , Issue.16 , pp. 1666-1675
    • Hsia, J.1    Macfadyen, J.G.2    Monyak, J.3    Ridker, P.M.4
  • 4
    • 67651111687 scopus 로고    scopus 로고
    • Lipid treatment assessment project 2 a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol Goals
    • Waters DD, Brotons C, Chiang C-W, et al. Lipid treatment assessment project 2 a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol Goals. Circulation 2009;120(1):28-34
    • (2009) Circulation , vol.120 , Issue.1 , pp. 28-34
    • Waters, D.D.1    Brotons, C.2    Chiang, C.-W.3
  • 5
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Reiner Z, Catapano AL, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011;32(14):1769-818
    • (2011) Eur Heart J , vol.32 , Issue.14 , pp. 1769-1818
    • Reiner, Z.1    Catapano, A.L.2    De Backer, G.3
  • 6
    • 84862119222 scopus 로고    scopus 로고
    • European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice
    • Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 2012; 33(13):1635-701
    • (2012) Eur Heart J , vol.33 , Issue.13 , pp. 1635-1701
    • Perk, J.1    De Backer, G.2    Gohlke, H.3
  • 7
    • 84889018792 scopus 로고    scopus 로고
    • 2013 ACC/AHA Guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the american college of cardiology/american heart association task force on practice guidelines
    • Epub ahead of print]
    • Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013. [Epub ahead of print]
    • (2013) J Am Coll Cardiol
    • Stone, N.J.1    Robinson, J.2    Lichtenstein, A.H.3
  • 8
    • 79958264458 scopus 로고    scopus 로고
    • Statin myopathy: A common dilemma not reflected in clinical trials
    • Fernandez G, Spatz ES, Jablecki C, Phillips PS. Statin myopathy: a common dilemma not reflected in clinical trials. Cleve Clin J Med 2011;78(6):393-403
    • (2011) Cleve Clin J Med , vol.78 , Issue.6 , pp. 393-403
    • Fernandez, G.1    Spatz, E.S.2    Jablecki, C.3    Phillips, P.S.4
  • 9
    • 81255165866 scopus 로고    scopus 로고
    • Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group consensus update
    • Mancini GB, Tashakkor AY, Baker S, et al. Diagnosis, prevention, and management of statin adverse effects and intolerance: canadian Working Group consensus update. Can J Cardiol 2011;27(5):635-62
    • (2011) Can J Cardiol , vol.27 , Issue.5 , pp. 635-662
    • Mancini, G.B.1    Tashakkor, A.Y.2    Baker, S.3
  • 10
    • 84862908066 scopus 로고    scopus 로고
    • Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative
    • Culver AL, Ockene IS, Balasubramanian R, et al. Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative. Arch Intern Med 2012; 172(2):144-52
    • (2012) Arch Intern Med , vol.172 , Issue.2 , pp. 144-152
    • Culver, A.L.1    Ockene, I.S.2    Balasubramanian, R.3
  • 11
    • 84866733914 scopus 로고    scopus 로고
    • Statins, risk of diabetes, and implications on outcomes in the general population
    • Wang KL, Liu CJ, Chao TF, et al. Statins, risk of diabetes, and implications on outcomes in the general population. J Am Coll Cardiol 2012;60(14):1231-8
    • (2012) J Am Coll Cardiol , vol.60 , Issue.14 , pp. 1231-1238
    • Wang, K.L.1    Liu, C.J.2    Chao, T.F.3
  • 12
    • 84883777708 scopus 로고    scopus 로고
    • Treatment strategies in patients with statin intolerance: The Cleveland Clinic experience
    • Mampuya WM, Frid D, Rocco M, et al. Treatment strategies in patients with statin intolerance: the Cleveland Clinic experience. Am Heart J 2013;166(3):597-603
    • (2013) Am Heart J , vol.166 , Issue.3 , pp. 597-603
    • Mampuya, W.M.1    Frid, D.2    Rocco, M.3
  • 13
    • 56249123656 scopus 로고    scopus 로고
    • The Residual Risk Reduction Initiative: A call to action to reduce residual vascular risk in dyslipidaemic patients
    • Fruchart JC, Sacks FM, Hermans MP, et al. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients. Diab Vasc Dis Res 2008;5(4):319-35
    • (2008) Diab Vasc Dis Res , vol.5 , Issue.4 , pp. 319-335
    • Fruchart, J.C.1    Sacks, F.M.2    Hermans, M.P.3
  • 14
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management
    • Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011;32(11): 1345-61
    • (2011) Eur Heart J , vol.32 , Issue.11 , pp. 1345-1361
    • Chapman, M.J.1    Ginsberg, H.N.2    Amarenco, P.3
  • 15
    • 0034968471 scopus 로고    scopus 로고
    • Effects on blood lipids of a blood pressure-lowering diet: The Dietary Approaches to Stop Hypertension (DASH) Trial
    • Obarzanek E, Sacks FM, Vollmer WM, et al. Effects on blood lipids of a blood pressure-lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr 2001;74(1): 80-9
    • (2001) Am J Clin Nutr , vol.74 , Issue.1 , pp. 80-89
    • Obarzanek, E.1    Sacks, F.M.2    Vollmer, W.M.3
  • 16
    • 84880323061 scopus 로고    scopus 로고
    • Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
    • The Look AHEAD Research Group.
    • The Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369(2):145-54
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 145-154
  • 17
    • 84871314601 scopus 로고    scopus 로고
    • Association of an intensive lifestyle intervention with remission of type 2 diabetes
    • Gregg EW, Chen H, Wagenknecht LE, et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA 2012;308(23): 2489-96
    • (2012) JAMA , vol.308 , Issue.23 , pp. 2489-2496
    • Gregg, E.W.1    Chen, H.2    Wagenknecht, L.E.3
  • 18
    • 77957690115 scopus 로고    scopus 로고
    • Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: Four-year results of the Look AHEAD trial
    • The Look AHEAD Research Group.
    • The Look AHEAD Research Group. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med 2010;170(17): 1566-75
    • (2010) Arch Intern Med , vol.170 , Issue.17 , pp. 1566-1575
  • 19
    • 84875787136 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with a Mediterranean diet
    • Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368(14):1279-90
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1279-1290
    • Estruch, R.1    Ros, E.2    Salas-Salvadó, J.3
  • 20
    • 80051960080 scopus 로고    scopus 로고
    • Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors
    • Nordmann AJ, Suter-Zimmermann K, Bucher HC, et al. Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors. Am J Med 2011;124(9):841-51.e842
    • (2011) Am J Med , vol.124 , Issue.9
    • Nordmann, A.J.1    Suter-Zimmermann, K.2    Bucher, H.C.3
  • 21
    • 77950861552 scopus 로고    scopus 로고
    • Very high plant stanol intake and serum plant stanols and non-cholesterol sterols
    • Gylling H, Hallikainen M, Nissinen MJ, et al. Very high plant stanol intake and serum plant stanols and non-cholesterol sterols. Eur J Nutr 2010;49(2):111-17
    • (2010) Eur J Nutr , vol.49 , Issue.2 , pp. 111-117
    • Gylling, H.1    Hallikainen, M.2    Nissinen, M.J.3
  • 22
    • 77954573574 scopus 로고    scopus 로고
    • Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d
    • Mensink RP, de Jong A, Lütjohann D, et al. Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. Am J Clin Nutr 2010;92(1):24-33
    • (2010) Am J Clin Nutr , vol.92 , Issue.1 , pp. 24-33
    • Mensink, R.P.1    De Jong, A.2    Lütjohann, D.3
  • 23
    • 84861234604 scopus 로고    scopus 로고
    • Effects of ethanol intake on lipoproteins
    • Brinton EA. Effects of ethanol intake on lipoproteins. Curr Atheroscler Rep 2012; 14(2):108-14
    • (2012) Curr Atheroscler Rep , vol.14 , Issue.2 , pp. 108-114
    • Brinton, E.A.1
  • 24
    • 79952028567 scopus 로고    scopus 로고
    • Severe hypertriglyceridemia influenced by alcohol (SHIBA)
    • Bessembinders K, Wielders J, van de Wiel A. Severe hypertriglyceridemia influenced by alcohol (SHIBA). Alcohol Alcohol 2011;46(2):113-16
    • (2011) Alcohol Alcohol , vol.46 , Issue.2 , pp. 113-116
    • Bessembinders, K.1    Wielders, J.2    Van De Wiel, A.3
  • 25
    • 67249153214 scopus 로고    scopus 로고
    • Red yeast rice for dyslipidemia in statin-intolerant patients: A randomized trial
    • Becker DJ, Gordon RY, Halbert SC, et al. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med 2009;150(12):830-9
    • (2009) Ann Intern Med , vol.150 , Issue.12 , pp. 830-839
    • Becker, D.J.1    Gordon, R.Y.2    Halbert, S.C.3
  • 26
    • 73149101073 scopus 로고    scopus 로고
    • Tolerability of red yeast rice (2, 400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance
    • Halbert SC, French B, Gordon RY, et al. Tolerability of red yeast rice (2, 400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. Am J Cardiol 2010;105(2): 198-204
    • (2010) Am J Cardiol , vol.105 , Issue.2 , pp. 198-204
    • Halbert, S.C.1    French, B.2    Gordon, R.Y.3
  • 27
    • 84880181705 scopus 로고    scopus 로고
    • Red yeast rice lowers cholesterol in physicians a double blind placebo controlled randomized trial
    • Verhoeven V, Lopez Hartmann M, Remmen R, et al. Red yeast rice lowers cholesterol in physicians-a double blind, placebo controlled randomized trial. BMC Complement Altern Med 2013;13(1):178
    • (2013) BMC Complement Altern Med , vol.13 , Issue.1 , pp. 178
    • Verhoeven, V.1    Lopez Hartmann, M.2    Remmen, R.3
  • 28
    • 84883399626 scopus 로고    scopus 로고
    • Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial
    • Na LX, Li Y, Pan HZ, et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res 2012;57:1569-77
    • (2012) Mol Nutr Food Res , vol.57 , pp. 1569-1577
    • Na, L.X.1    Li, Y.2    Pan, H.Z.3
  • 29
    • 84892527914 scopus 로고    scopus 로고
    • Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial
    • Chuengsamarn S, Rattanamongkolgul S, Phonrat B, et al. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem 2013;25: 144-50
    • (2013) J Nutr Biochem , vol.25 , pp. 144-150
    • Chuengsamarn, S.1    Rattanamongkolgul, S.2    Phonrat, B.3
  • 30
    • 77957295590 scopus 로고    scopus 로고
    • A 50-week extension study on the safety and efficacy of colesevelam in adults with primary hypercholesterolemia
    • Davidson MH, Donovan JM, Misir S, Jones MR. A 50-week extension study on the safety and efficacy of colesevelam in adults with primary hypercholesterolemia. Am J Cardiovasc Drugs 2010;10(5):305-14
    • (2010) Am J Cardiovasc Drugs , vol.10 , Issue.5 , pp. 305-314
    • Davidson, M.H.1    Donovan, J.M.2    Misir, S.3    Jones, M.R.4
  • 31
    • 84864216037 scopus 로고    scopus 로고
    • Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus
    • Goldberg RB, Rosenson RS, Hernandez-Triana E, et al. Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus. J Clin Lipidol 2012;6(4):318-24
    • (2012) J Clin Lipidol , vol.6 , Issue.4 , pp. 318-324
    • Goldberg, R.B.1    Rosenson, R.S.2    Hernandez-Triana, E.3
  • 32
    • 84876038812 scopus 로고    scopus 로고
    • Colesevelam improved lipoprotein particle subclasses in patients with prediabetes and primary hyperlipidaemia
    • Goldberg RB, Rosenson RS, Hernandez-Triana E, et al. Colesevelam improved lipoprotein particle subclasses in patients with prediabetes and primary hyperlipidaemia. Diab Vasc Dis Res 2013; 10(3):256-62
    • (2013) Diab Vasc Dis Res , vol.10 , Issue.3 , pp. 256-262
    • Goldberg, R.B.1    Rosenson, R.S.2    Hernandez-Triana, E.3
  • 33
    • 80053954040 scopus 로고    scopus 로고
    • Effect of colesevelam hydrochloride on glycemia and insulin sensitivity in men with the metabolic syndrome
    • Vega GL, Dunn FL, Grundy SM. Effect of colesevelam hydrochloride on glycemia and insulin sensitivity in men with the metabolic syndrome. Am J Cardiol 2011;108(8): 1129-35
    • (2011) Am J Cardiol , vol.108 , Issue.8 , pp. 1129-1135
    • Vega, G.L.1    Dunn, F.L.2    Grundy, S.M.3
  • 34
    • 54049103635 scopus 로고    scopus 로고
    • Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: Glucose and lipid effects
    • Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch Intern Med 2008; 168(18):1975-83
    • (2008) Arch Intern Med , vol.168 , Issue.18 , pp. 1975-1983
    • Bays, H.E.1    Goldberg, R.B.2    Truitt, K.E.3    Jones, M.R.4
  • 35
    • 84856701167 scopus 로고    scopus 로고
    • Effect of bile acid sequestrants on glucose metabolism hepatic de novo lipogenesis and cholesterol and bile acid kinetics in type 2 diabetes: A randomised controlled study
    • Beysen C, Murphy EJ, Deines K, et al. Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. Diabetologia 2012;55(2): 432-42
    • (2012) Diabetologia , vol.55 , Issue.2 , pp. 432-442
    • Beysen, C.1    Murphy, E.J.2    Deines, K.3
  • 36
    • 84888630610 scopus 로고    scopus 로고
    • Colesevelam in the treatment of hypercholesterolemia and hyperglycemia: A retrospective analysis from an ambulatory care medical network
    • Romanelli RJ, Leahy A, Jukes T, et al. Colesevelam in the treatment of hypercholesterolemia and hyperglycemia: a retrospective analysis from an ambulatory care medical network. Curr Med Res Opin 2013;29(12):1747-56
    • (2013) Curr Med Res Opin , vol.29 , Issue.12 , pp. 1747-1756
    • Romanelli, R.J.1    Leahy, A.2    Jukes, T.3
  • 37
    • 64249120001 scopus 로고    scopus 로고
    • Ezetimibe monotherapy for cholesterol lowering in 2, 722 people: Systematic review and meta analysis of randomized controlled trials
    • Pandor A, Ara RM, Tumur I, et al. Ezetimibe monotherapy for cholesterol lowering in 2, 722 people: systematic review and meta analysis of randomized controlled trials. J Intern Med 2009;265(5):568-80
    • (2009) J Intern Med , vol.265 , Issue.5 , pp. 568-580
    • Pandor, A.1    Ara, R.M.2    Tumur, I.3
  • 38
    • 77953539404 scopus 로고    scopus 로고
    • The SEAS trial
    • Carabello BA. The SEAS Trial. Curr Cardiol Rep 2010;12(2):122-4
    • (2010) Curr Cardiol Rep , vol.12 , Issue.2 , pp. 122-124
    • Carabello, B.A.1
  • 39
    • 84860127612 scopus 로고    scopus 로고
    • Effect of lipid lowering on new-onset atrial fibrillation in patients with asymptomatic aortic stenosis: The Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study
    • Bang CN, Greve AM, Boman K, et al. Effect of lipid lowering on new-onset atrial fibrillation in patients with asymptomatic aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Am Heart J 2012;163(4):690-6
    • (2012) Am Heart J , vol.163 , Issue.4 , pp. 690-696
    • Bang, C.N.1    Greve, A.M.2    Boman, K.3
  • 40
    • 79959746706 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (study of heart and renal protection): A randomised placebo-controlled trial
    • Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (study of heart and renal protection): a randomised placebo-controlled trial. Lancet 2011; 377(9784):2181-92
    • (2011) Lancet , vol.377 , Issue.9784 , pp. 2181-2192
    • Baigent, C.1    Landray, M.J.2    Reith, C.3
  • 41
    • 50949102416 scopus 로고    scopus 로고
    • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    • Cannon CP, Giugliano RP, Blazing MA, et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J 2008;156(5):826-32
    • (2008) Am Heart J , vol.156 , Issue.5 , pp. 826-832
    • Cannon, C.P.1    Giugliano, R.P.2    Blazing, M.A.3
  • 42
    • 77951622890 scopus 로고    scopus 로고
    • An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design
    • Califf RM, Lokhnygina Y, Cannon CP, et al. An update on the IMProved reduction of outcomes: vytorin Efficacy International Trial (IMPROVE-IT) design. Am Heart J 2010;159(5):705-9
    • (2010) Am Heart J , vol.159 , Issue.5 , pp. 705-709
    • Califf, R.M.1    Lokhnygina, Y.2    Cannon, C.P.3
  • 43
    • 34147131830 scopus 로고    scopus 로고
    • Colesevelam hydrochloride-ezetimibe combination lipid-lowering therapy in patients with diabetes or metabolic syndrome and a history of statin intolerance
    • Rivers SM, Kane MP, Busch RS, et al. Colesevelam hydrochloride-ezetimibe combination lipid-lowering therapy in patients with diabetes or metabolic syndrome and a history of statin intolerance. Endocr Pract 2007;13(1):11-16
    • (2007) Endocr Pract , vol.13 , Issue.1 , pp. 11-16
    • Rivers, S.M.1    Kane, M.P.2    Busch, R.S.3
  • 44
    • 77952674608 scopus 로고    scopus 로고
    • Effect of ezetimibe on hepatic fat inflammatory markers and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet
    • Chan DC, Watts GF, Gan SK, et al. Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet. Diabetes Care 2010;33(5): 1134-9
    • (2010) Diabetes Care , vol.33 , Issue.5 , pp. 1134-1139
    • Chan, D.C.1    Watts, G.F.2    Gan, S.K.3
  • 45
    • 84863554957 scopus 로고    scopus 로고
    • Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia
    • Tamaki N, Ueno H, Morinaga Y, et al. Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia. J Atheroscler Thromb 2012;19(6):532-8
    • (2012) J Atheroscler Thromb , vol.19 , Issue.6 , pp. 532-538
    • Tamaki, N.1    Ueno, H.2    Morinaga, Y.3
  • 46
    • 84883825336 scopus 로고    scopus 로고
    • Comparative cardiometabolic effects of fibrates and omega-3 fatty acids
    • Han SH, Oh PC, Lim S, et al. Comparative cardiometabolic effects of fibrates and omega-3 fatty acids. Int J Cardiol 2013;167:2404-11
    • (2013) Int J Cardiol , vol.167 , pp. 2404-2411
    • Han, S.H.1    Oh, P.C.2    Lim, S.3
  • 47
    • 84878652813 scopus 로고    scopus 로고
    • The role of fibrate treatment in dyslipidemia: An overview
    • Katsiki N, Nikolic D, Montalto G, et al. The role of fibrate treatment in dyslipidemia: an overview. Curr Pharm Des 2013;19(17):3124-31
    • (2013) Curr Pharm des , vol.19 , Issue.17 , pp. 3124-3131
    • Katsiki, N.1    Nikolic, D.2    Montalto, G.3
  • 48
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • The FIELD Study Investigators
    • The FIELD Study Investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005; 366(9500):1849-61
    • (2005) Lancet , vol.366 , Issue.9500 , pp. 1849-1861
  • 49
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • The ACCORD Study Group.
    • The ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010;362(17): 1563-74
    • (2010) N Engl J Med , vol.362 , Issue.17 , pp. 1563-1574
  • 50
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome
    • Scott R, O'Brien R, Fulcher G, et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome. Diabetes Care 2009;32(3):493-8
    • (2009) Diabetes Care , vol.32 , Issue.3 , pp. 493-498
    • Scott, R.1    O'Brien, R.2    Fulcher, G.3
  • 51
    • 77956631532 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in the management of patients with type 2 diabetes mellitus in the action to control cardiovascular risk in diabetes (ACCORD) Trial
    • Tonkin AM, Chen L. Effects of Combination Lipid Therapy in the Management of Patients With Type 2 Diabetes Mellitus in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Circulation 2010;122(8): 850-2
    • (2010) Circulation , vol.122 , Issue.8 , pp. 850-852
    • Tonkin, A.M.1    Chen, L.2
  • 52
    • 36049001784 scopus 로고    scopus 로고
    • Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial
    • Keech AC, Mitchell P, Summanen PA, et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 2007;370(9600):1687-97
    • (2007) Lancet , vol.370 , Issue.9600 , pp. 1687-1697
    • Keech, A.C.1    Mitchell, P.2    Summanen, P.A.3
  • 53
    • 78951474167 scopus 로고    scopus 로고
    • Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
    • Davis TME, Ting R, Best JD, et al. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study. Diabetologia 2011;54(2):280-90
    • (2011) Diabetologia , vol.54 , Issue.2 , pp. 280-290
    • Tme, D.1    Ting, R.2    Best, J.D.3
  • 54
    • 77955585592 scopus 로고    scopus 로고
    • Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial
    • Ismail-Beigi F, Craven T, Banerji MA, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet 2010; 376(9739):419-30
    • (2010) Lancet , vol.376 , Issue.9739 , pp. 419-430
    • Ismail-Beigi, F.1    Craven, T.2    Banerji, M.A.3
  • 55
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010;375(9729):1875-84
    • (2010) Lancet , vol.375 , Issue.9729 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 56
    • 79960700766 scopus 로고    scopus 로고
    • Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: A meta-analysis
    • Lee M, Saver JL, Towfighi A, et al. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis. Atherosclerosis 2011;217(2): 492-8
    • (2011) Atherosclerosis , vol.217 , Issue.2 , pp. 492-498
    • Lee, M.1    Saver, J.L.2    Towfighi, A.3
  • 57
    • 33646035503 scopus 로고    scopus 로고
    • Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia
    • McKenney JM, Farnier M, Lo K-W, et al. Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia. J Am Coll Cardiol 2006;47(8):1584-7
    • (2006) J Am Coll Cardiol , vol.47 , Issue.8 , pp. 1584-1587
    • McKenney, J.M.1    Farnier, M.2    Lo, K.-W.3
  • 58
    • 77952955394 scopus 로고    scopus 로고
    • Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk
    • Chapman MJ, Redfern JS, McGovern ME, Giral P. Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk. Pharmacol Ther 2010; 126(3):314-45
    • (2010) Pharmacol Ther , vol.126 , Issue.3 , pp. 314-345
    • Chapman, M.J.1    Redfern, J.S.2    McGovern, M.E.3    Giral, P.4
  • 59
    • 1542780828 scopus 로고    scopus 로고
    • Niacin, lipids, and heart disease
    • Malik S, Kashyap ML. Niacin, lipids, and heart disease. Curr Cardiol Rep 2003;5(6): 470-6
    • (2003) Curr Cardiol Rep , vol.5 , Issue.6 , pp. 470-476
    • Malik, S.1    Kashyap, M.L.2
  • 60
    • 0023001772 scopus 로고
    • Fifteen year mortality in coronary drug project patients: Long-term benefit with niacin
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in coronary drug project patients: long-term benefit with niacin. J Am Coll Cardiol 1986;8(6): 1245-55
    • (1986) J Am Coll Cardiol , vol.8 , Issue.6 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 61
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345(22):1583-92
    • (2001) N Engl J Med , vol.345 , Issue.22 , pp. 1583-1592
    • Brown, B.G.1    Zhao, X.Q.2    Chait, A.3
  • 62
    • 10044281651 scopus 로고    scopus 로고
    • Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2 a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor AJ. Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2 a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 2004; 110(23):3512-17
    • (2004) Circulation , vol.110 , Issue.23 , pp. 3512-3517
    • Taylor, A.J.1
  • 63
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3*
    • Taylor AJ, Lee HJ, Sullenberger LE. The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3*. Curr Med Res Opin 2006;22(11):2243-50
    • (2006) Curr Med Res Opin , vol.22 , Issue.11 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 64
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • The AIM-HIGH Investigators.
    • The AIM-HIGH Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 2011;365(24):2255-67
    • (2011) N Engl J Med , vol.365 , Issue.24 , pp. 2255-2267
  • 65
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25673 high-risk patients of ER niacin/laropiprant: Trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • HPS2-THRIVE Collaborative Group.
    • HPS2-THRIVE Collaborative Group. HPS2-THRIVE randomized placebo-controlled trial in 25673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur Heart J 2013;34(17): 1279-91
    • (2013) Eur Heart J , vol.34 , Issue.17 , pp. 1279-1291
  • 66
    • 84886000801 scopus 로고    scopus 로고
    • Relationship of lipoproteins to cardiovascular events in the atherothrombosis intervention in metabolic syndrome with low hdl/high triglycerides and impact on global health outcomes (AIM-HIGH) trial
    • Guyton JR, Slee AE, Anderson T, et al. Relationship of lipoproteins to cardiovascular events in the atherothrombosis intervention in metabolic syndrome with low hdl/high triglycerides and impact on global health outcomes (AIM-HIGH) trial. J Am Coll Cardiol 2013;62(17):1580-4
    • (2013) J Am Coll Cardiol , vol.62 , Issue.17 , pp. 1580-1584
    • Guyton, J.R.1    Slee, A.E.2    Anderson, T.3
  • 67
    • 84867078868 scopus 로고    scopus 로고
    • Safety of inhibition of cholesteryl ester transfer protein with anacetrapib: The DEFINE study
    • Gotto AM Jr, Moon JE. Safety of inhibition of cholesteryl ester transfer protein with anacetrapib: the DEFINE study. Expert Rev Cardiovasc Ther 2012; 10(8):955-63
    • (2012) Expert Rev Cardiovasc Ther , vol.10 , Issue.8 , pp. 955-963
    • Gotto Jr., A.M.1    Moon, J.E.2
  • 68
    • 34047106220 scopus 로고    scopus 로고
    • Effect of torcetrapib on the progression of coronary atherosclerosis
    • Nissen SE, Tardif JC, Nicholls SJ, et al. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 2007;356(13):1304-16
    • (2007) N Engl J Med , vol.356 , Issue.13 , pp. 1304-1316
    • Nissen, S.E.1    Tardif, J.C.2    Nicholls, S.J.3
  • 69
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007; 357(21):2109-22
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 70
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • Forrest MJ, Bloomfield D, Briscoe RJ, et al. Torcetrapib induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol 2008; 154(7):1465-73
    • (2008) Br J Pharmacol , vol.154 , Issue.7 , pp. 1465-1473
    • Forrest, M.J.1    Bloomfield, D.2    Briscoe, R.J.3
  • 71
    • 84870045994 scopus 로고    scopus 로고
    • Effects of dalcetrapib in patients with a recent acute coronary syndrome
    • Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 2012;367(22):2089-99
    • (2012) N Engl J Med , vol.367 , Issue.22 , pp. 2089-2099
    • Schwartz, G.G.1    Olsson, A.G.2    Abt, M.3
  • 72
    • 78549235583 scopus 로고    scopus 로고
    • Safety of anacetrapib in patients with or at high risk for coronary heart disease
    • Cannon CP, Shah S, Dansky HM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med 2010;363(25):2406-15
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2406-2415
    • Cannon, C.P.1    Shah, S.2    Dansky, H.M.3
  • 73
    • 81255125373 scopus 로고    scopus 로고
    • Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: A randomized controlled trial
    • Nicholls SJ, Brewer H, Kastelein JP, et al. Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial. JAMA 2011;306(19):2099-109
    • (2011) JAMA , vol.306 , Issue.19 , pp. 2099-2109
    • Nicholls, S.J.1    Brewer, H.2    Kastelein, J.P.3
  • 74
    • 77956063072 scopus 로고    scopus 로고
    • Cardiovascular effects of marine omega-3 fatty acids
    • Saravanan P, Davidson NC, Schmidt EB, Calder PC. Cardiovascular effects of marine omega-3 fatty acids. Lancet 2010; 376(9740):540-50
    • (2010) Lancet , vol.376 , Issue.9740 , pp. 540-550
    • Saravanan, P.1    Davidson, N.C.2    Schmidt, E.B.3    Calder, P.C.4
  • 75
    • 84864219466 scopus 로고    scopus 로고
    • N-Fatty acids and cardiovascular outcomes in patients with dysglycemia
    • The ORIGIN Trial Investigators.
    • The ORIGIN Trial Investigators. n-Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia. N Engl J Med 2012;367:309-18
    • (2012) N Engl J Med , vol.367 , pp. 309-318
  • 76
    • 84877624255 scopus 로고    scopus 로고
    • N-fatty acids in patients with multiple cardiovascular risk factors
    • The Risk and Prevention Study Collaborative Group.
    • The Risk and Prevention Study Collaborative Group. n-fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med 2013;368(19):1800-8
    • (2013) N Engl J Med , vol.368 , Issue.19 , pp. 1800-1808
  • 77
    • 84866070612 scopus 로고    scopus 로고
    • Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events a systematic review and meta-analysis
    • Rizos EC, Ntzani EE, Bika E, et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events-a systematic review and meta-analysis. JAMA 2012; 308(10):1024-33
    • (2012) JAMA , vol.308 , Issue.10 , pp. 1024-1033
    • Rizos, E.C.1    Ntzani, E.E.2    Bika, E.3
  • 78
    • 84861128254 scopus 로고    scopus 로고
    • Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: A meta-analysis of randomized, double-blind, placebo-controlled trials
    • Korean Meta-analysis Study Group.
    • Kwak SM, Myung SK, Lee YJ, Seo HG; Korean Meta-analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med 2012;172(9):686-94
    • (2012) Arch Intern Med , vol.172 , Issue.9 , pp. 686-694
    • Kwak, S.M.1    Myung, S.K.2    Lee, Y.J.3    Seo, H.G.4
  • 80
    • 84897111952 scopus 로고    scopus 로고
    • The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: A meta-analysis
    • [Epub ahead of print]
    • Zheng T, Zhao J, Wang Y, et al. The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: a meta-analysis. Clin Biochem 2013. [Epub ahead of print]
    • (2013) Clin Biochem
    • Zheng, T.1    Zhao, J.2    Wang, Y.3
  • 81
    • 0036124659 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials
    • Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002;112(4):298-304
    • (2002) Am J Med , vol.112 , Issue.4 , pp. 298-304
    • Bucher, H.C.1    Hengstler, P.2    Schindler, C.3    Meier, G.4
  • 82
    • 67749093275 scopus 로고    scopus 로고
    • Omega-3 dietary supplements and the risk of cardiovascular events: A systematic review
    • Marik PE, Varon J. Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review. Clin Cardiol 2009;32(7):365-72
    • (2009) Clin Cardiol , vol.32 , Issue.7 , pp. 365-372
    • Marik, P.E.1    Varon, J.2
  • 83
    • 79551499975 scopus 로고    scopus 로고
    • Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: A randomised placebo controlled trial
    • Galan P, Kesse-Guyot E, Czernichow S, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. Br Med J 2010;341:c6273
    • (2010) Br Med J , vol.341
    • Galan, P.1    Kesse-Guyot, E.2    Czernichow, S.3
  • 84
    • 78549233384 scopus 로고    scopus 로고
    • N-3 Fatty acids and cardiovascular events after myocardial infarction
    • Kromhout D, Giltay EJ, Geleijnse JM. n-3 Fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 2010; 363(21):2015-26
    • (2010) N Engl J Med , vol.363 , Issue.21 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.J.2    Geleijnse, J.M.3
  • 85
    • 78650169331 scopus 로고    scopus 로고
    • OMEGA a randomized placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction clinical perspective
    • Rauch B, Schiele R, Schneider S, et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction clinical perspective. Circulation 2010;122(21):2152-9
    • (2010) Circulation , vol.122 , Issue.21 , pp. 2152-2159
    • Rauch, B.1    Schiele, R.2    Schneider, S.3
  • 86
    • 77958588654 scopus 로고    scopus 로고
    • A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk
    • Einvik G, Klemsdal TO, Sandvik L, Hjerkinn EM. A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk. Eur J Cardiovasc Prev Rehabil 2010;17(5): 588-92
    • (2010) Eur J Cardiovasc Prev Rehabil , vol.17 , Issue.5 , pp. 588-592
    • Einvik, G.1    Klemsdal, T.O.2    Sandvik, L.3    Hjerkinn, E.M.4
  • 87
    • 84867355977 scopus 로고    scopus 로고
    • The big ones that got away: Omega-3 meta-analysis flawed by excluding the biggest fish oil trials
    • DiNicolantonio JJ, O'Keefe JH, Lavie CJ. The big ones that got away: omega-3 meta-analysis flawed by excluding the biggest fish oil trials. Arch Intern Med 2012;172(18): 1427-8
    • (2012) Arch Intern Med , vol.172 , Issue.18 , pp. 1427-1428
    • Dinicolantonio, J.J.1    O'Keefe, J.H.2    Lavie, C.J.3
  • 88
    • 77955148343 scopus 로고    scopus 로고
    • Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: Rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice
    • Avanzini F, Barlera S, Caimi V, et al. Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice. Trials 2010;11:68
    • (2010) Trials , vol.11 , pp. 68
    • Avanzini, F.1    Barlera, S.2    Caimi, V.3
  • 89
    • 84855341899 scopus 로고    scopus 로고
    • OmegA-3 TriaL (VITAL): Rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    • The VITamin D and.
    • Manson JE, Bassuk SS, Lee IM, et al. The VITamin D and. OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012;33(1):159-71
    • (2012) Contemp Clin Trials , vol.33 , Issue.1 , pp. 159-171
    • Manson, J.E.1    Bassuk, S.S.2    Lee, I.M.3
  • 90
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369(9567):1090-8
    • (2007) Lancet , vol.369 , Issue.9567 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 91
    • 80051784104 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    • Bays HE, Ballantyne CM, Kastelein JJ, et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Am J Cardiol 2011;108(5):682-90
    • (2011) Am J Cardiol , vol.108 , Issue.5 , pp. 682-690
    • Bays, H.E.1    Ballantyne, C.M.2    Kastelein, J.J.3
  • 92
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR Study)
    • Ballantyne CM, Bays HE, Kastelein JJ, et al. Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study). Am J Cardiol 2012;110(7):984-92
    • (2012) Am J Cardiol , vol.110 , Issue.7 , pp. 984-992
    • Ballantyne, C.M.1    Bays, H.E.2    Kastelein, J.J.3
  • 93
    • 84880617689 scopus 로고    scopus 로고
    • Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes mellitus patients: A double-blind randomised clinical trial
    • Sarbolouki S, Javanbakht MH, Derakhshanian H, et al. Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes mellitus patients: a double-blind randomised clinical trial. Singapore Med J 2013;54(7):387-90
    • (2013) Singapore Med J , vol.54 , Issue.7 , pp. 387-390
    • Sarbolouki, S.1    Javanbakht, M.H.2    Derakhshanian, H.3
  • 94
    • 84896749846 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid may increase the low-density lipoprotein particle size by improving triglyceride metabolism in patients with hypertriglyceridemia
    • Tani S, Nagao K, Matsumoto M, et al. Highly purified eicosapentaenoic acid may increase the low-density lipoprotein particle size by improving triglyceride metabolism in patients with hypertriglyceridemia. Eur Heart J 2013;34(Suppl 1):P695
    • (2013) Eur Heart J , vol.34 , Issue.SUPPL. 1
    • Tani, S.1    Nagao, K.2    Matsumoto, M.3
  • 95
    • 33845511343 scopus 로고    scopus 로고
    • Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols
    • Demonty I, Chan Y-M, Pelled D, Jones PJ. Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. Am J clin Nutr 2006;84(6): 1534-42
    • (2006) Am J Clin Nutr , vol.84 , Issue.6 , pp. 1534-1542
    • Demonty, I.1    Chan, Y.-M.2    Pelled, D.3    Jones, P.J.4
  • 96
    • 79958204676 scopus 로고    scopus 로고
    • The metabolic effects of omega-3 plant sterol esters in mixed hyperlipidemic subjects
    • Bitzur R, Cohen H, Cohen T, et al. The metabolic effects of omega-3 plant sterol esters in mixed hyperlipidemic subjects. Cardiovasc Drugs Ther 2010;24(5-6): 429-37
    • (2010) Cardiovasc Drugs Ther , vol.24 , Issue.5-6 , pp. 429-437
    • Bitzur, R.1    Cohen, H.2    Cohen, T.3
  • 97
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • Meier JJ, Gethmann A, Götze O, et al. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia 2006;49(3):452-8
    • (2006) Diabetologia , vol.49 , Issue.3 , pp. 452-458
    • Meier, J.J.1    Gethmann, A.2    Götze, O.3
  • 98
    • 79951884751 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-based therapies and cardiovascular disease: Looking beyond glycaemic control
    • Anagnostis P, Athyros VG, Adamidou F, et al. Glucagon-like peptide-1-based therapies and cardiovascular disease: looking beyond glycaemic control. Diabetes Obes Metab 2011;13(4):302-12
    • (2011) Diabetes Obes Metab , vol.13 , Issue.4 , pp. 302-312
    • Anagnostis, P.1    Athyros, V.G.2    Adamidou, F.3
  • 99
    • 84857903646 scopus 로고    scopus 로고
    • DPP-4 inhibitors and lipids: Systematic review and meta-analysis
    • Monami M, Lamanna C, Desideri CM, Mannucci E. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv Ther 2012;29(1):14-25
    • (2012) Adv Ther , vol.29 , Issue.1 , pp. 14-25
    • Monami, M.1    Lamanna, C.2    Desideri, C.M.3    Mannucci, E.4
  • 100
    • 84871936025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: A meta-analysis of randomized clinical trials
    • Monami M, Ahrén B, Dicembrini I, Mannucci E. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2013;15(2):112-20
    • (2013) Diabetes Obes Metab , vol.15 , Issue.2 , pp. 112-120
    • Monami, M.1    Ahrén, B.2    Dicembrini, I.3    Mannucci, E.4
  • 101
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369:1317-26
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 102
    • 33846443997 scopus 로고    scopus 로고
    • Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist
    • Sprecher DL, Massien C, Pearce G, et al. Triglyceride: high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist. Arterioscler Thromb Vasc Biol 2007;27(2):359-65
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.2 , pp. 359-365
    • Sprecher, D.L.1    Massien, C.2    Pearce, G.3
  • 103
    • 39649101196 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR) d promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    • Risérus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR) d promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes 2008;57(2):332-9
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 332-339
    • Risérus, U.1    Sprecher, D.2    Johnson, T.3
  • 104
    • 84885400267 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta and cardiovascular disease
    • Ehrenborg E, Skogsberg J. Peroxisome proliferator-activated receptor delta and cardiovascular disease. Atherosclerosis 2013; 231(1):95-106
    • (2013) Atherosclerosis , vol.231 , Issue.1 , pp. 95-106
    • Ehrenborg, E.1    Skogsberg, J.2
  • 105
    • 80052539818 scopus 로고    scopus 로고
    • MBX-8025, a novel peroxisome proliferator receptor-d agonist: Lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin
    • Bays HE, Schwartz S, Littlejohn T, et al. MBX-8025, a novel peroxisome proliferator receptor-d agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab 2011; 96(9):2889-97
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.9 , pp. 2889-2897
    • Bays, H.E.1    Schwartz, S.2    Littlejohn, T.3
  • 106
    • 84855936714 scopus 로고    scopus 로고
    • Effects of the PPAR-d agonist MBX-8025 on atherogenic dyslipidemia
    • Choi Y-J, Roberts BK, Wang X, et al. Effects of the PPAR-d agonist MBX-8025 on atherogenic dyslipidemia. Atherosclerosis 2012;220(2):470-6
    • (2012) Atherosclerosis , vol.220 , Issue.2 , pp. 470-476
    • Choi, Y.-J.1    Roberts, B.K.2    Wang, X.3
  • 107
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPARa/d agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • Cariou B, Zäir Y, Staels B, Bruckert E. Effects of the new dual PPARa/d agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care 2011;34(9): 2008-14
    • (2011) Diabetes Care , vol.34 , Issue.9 , pp. 2008-2014
    • Cariou, B.1    Zäir, Y.2    Staels, B.3    Bruckert, E.4
  • 108
    • 84883790112 scopus 로고    scopus 로고
    • Evaluation of the dual peroxisome proliferator-activated receptor a/g agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: Rationale and design of the AleCardio trial
    • Lincoff AM, Tardif J-C, Neal B, et al. Evaluation of the dual peroxisome proliferator-activated receptor a/g agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: rationale and design of the AleCardio trial. Am Heart J 2013;166(3):429-34.e421
    • (2013) Am Heart J , vol.166 , Issue.3
    • Lincoff, A.M.1    Tardif, J.-C.2    Neal, B.3
  • 109
    • 84878349086 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptoralpha modulators (SPPARMalpha): The next generation of peroxisome proliferator-activated receptor alpha-agonists
    • Fruchart J-C. Selective peroxisome proliferator-activated receptoralpha modulators (SPPARMalpha): the next generation of peroxisome proliferator- activated receptor alpha-agonists. Cardiovasc Diabetol 2013;12(1):82
    • (2013) Cardiovasc Diabetol , vol.12 , Issue.1 , pp. 82
    • Fruchart, J.-C.1
  • 110
    • 38149050613 scopus 로고    scopus 로고
    • The role of angiopoietin-like proteins in angiogenesis and metabolism
    • Hato T, Tabata M, Oike Y. The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med 2008;18(1):6-14
    • (2008) Trends Cardiovasc Med , vol.18 , Issue.1 , pp. 6-14
    • Hato, T.1    Tabata, M.2    Oike, Y.3
  • 111
    • 0036847133 scopus 로고    scopus 로고
    • Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
    • Yoshida K, Shimizugawa T, Ono M, Furukawa H. Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res 2002;43(11):1770-2
    • (2002) J Lipid Res , vol.43 , Issue.11 , pp. 1770-1772
    • Yoshida, K.1    Shimizugawa, T.2    Ono, M.3    Furukawa, H.4
  • 112
    • 67649389843 scopus 로고    scopus 로고
    • Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)
    • Lee EC, Desai U, Gololobov G, et al. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem 2009;284(20): 13735-45
    • (2009) J Biol Chem , vol.284 , Issue.20 , pp. 13735-13745
    • Lee, E.C.1    Desai, U.2    Gololobov, G.3
  • 113
    • 84890392586 scopus 로고    scopus 로고
    • Antibodies to human angiopoietin-like protein 3: A patent evaluation of WO2012174178
    • Nakajima K, Kobayashi J. Antibodies to human angiopoietin-like protein 3: a patent evaluation of WO2012174178. Expert Opin Ther Pat 2014;24(1):113-19
    • (2014) Expert Opin Ther Pat , vol.24 , Issue.1 , pp. 113-119
    • Nakajima, K.1    Kobayashi, J.2
  • 114
    • 78751519853 scopus 로고    scopus 로고
    • Genetic determinants of plasma triglycerides
    • Johansen CT, Kathiresan S, Hegele RA. Genetic determinants of plasma triglycerides. J Lipid Res 2011;52(2): 189-206
    • (2011) J Lipid Res , vol.52 , Issue.2 , pp. 189-206
    • Johansen, C.T.1    Kathiresan, S.2    Hegele, R.A.3
  • 115
    • 84863986988 scopus 로고    scopus 로고
    • Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia
    • Surendran RP, Visser ME, Heemelaar S, et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med 2012;272(2):185-96
    • (2012) J Intern Med , vol.272 , Issue.2 , pp. 185-196
    • Surendran, R.P.1    Visser, M.E.2    Heemelaar, S.3
  • 116
    • 84883230802 scopus 로고    scopus 로고
    • Plasmapheresis in the management of severe hypertriglyceridemia
    • Seda G, Meyer JM, Amundson DE, Daheshia M. Plasmapheresis in the management of severe hypertriglyceridemia. Crit Care Nurse 2013;33(4):18-23
    • (2013) Crit Care Nurse , vol.33 , Issue.4 , pp. 18-23
    • Seda, G.1    Meyer, J.M.2    Amundson, D.E.3    Daheshia, M.4
  • 117
    • 77958017152 scopus 로고    scopus 로고
    • Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia
    • Hovland A, Hardersen R, Mollnes TE, Lappega°rd KT. Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia. JOP 2010;11(5):467-9
    • (2010) JOP , vol.11 , Issue.5 , pp. 467-469
    • Hovland, A.1    Hardersen, R.2    Mollnes, T.E.3    Lappegard, K.T.4
  • 119
    • 4344637236 scopus 로고    scopus 로고
    • Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis
    • Chen J-H, Yeh J-H, Lai H-W, Liao C-S. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol 2004;10(15):2272-4
    • (2004) World J Gastroenterol , vol.10 , Issue.15 , pp. 2272-2274
    • Chen, J.-H.1    Yeh, J.-H.2    Lai, H.-W.3    Liao, C.-S.4
  • 120
    • 84872172890 scopus 로고    scopus 로고
    • Treatment options for severe hypertriglyceridemia (SHTG): The role of apheresis
    • Ewald PDDN, Kloer H-U. Treatment options for severe hypertriglyceridemia (SHTG): the role of apheresis. Clin Res Cardiol Suppl 2012;7(1):31-5
    • (2012) Clin Res Cardiol Suppl , vol.7 , Issue.1 , pp. 31-35
    • Pddn, E.1    Kloer, H.-U.2
  • 121
    • 84875962928 scopus 로고    scopus 로고
    • Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: An open-label trial
    • Gaudet D, Methot J, Dery S, et al. Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial. Gene Ther 2013;20(4):361-9
    • (2013) Gene Ther , vol.20 , Issue.4 , pp. 361-369
    • Gaudet, D.1    Methot, J.2    Dery, S.3
  • 122
    • 84870874338 scopus 로고    scopus 로고
    • Alipogene tiparvovec: Gene therapy for lipoprotein lipase deficiency
    • Wierzbicki AS, Viljoen A. Alipogene tiparvovec: gene therapy for lipoprotein lipase deficiency. Expert Opin Biol Ther 2013;13(1):7-10
    • (2013) Expert Opin Biol Ther , vol.13 , Issue.1 , pp. 7-10
    • Wierzbicki, A.S.1    Viljoen, A.2
  • 123
    • 84860754546 scopus 로고    scopus 로고
    • Effect of Alipogene Tiparvovec (AAV1-LPLS447X) on Postprandial Chylomicron Metabolism in Lipoprotein Lipase-Deficient Patients
    • Carpentier AC, Frisch F, Labbé SM, et al. Effect of Alipogene Tiparvovec (AAV1-LPLS447X) on Postprandial Chylomicron Metabolism in Lipoprotein Lipase-Deficient Patients. J Clin Endocrinol Metab 2012; 97(5):1635-44
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.5 , pp. 1635-1644
    • Carpentier, A.C.1    Frisch, F.2    Labbé, S.M.3
  • 124
    • 0030712388 scopus 로고    scopus 로고
    • Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia
    • Wierzbicki AS, Lumb PJ, Cheung J, Crook MA. Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia. QJM 1997;90(10): 631-4
    • (1997) QJM , vol.90 , Issue.10 , pp. 631-634
    • Wierzbicki, A.S.1    Lumb, P.J.2    Cheung, J.3    Crook, M.A.4
  • 125
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358(14):1431-43
    • (2008) N Engl J Med , vol.358 , Issue.14 , pp. 1431-1443
    • Jjp, K.1    Akdim, F.2    Esg, S.3
  • 126
    • 77952525229 scopus 로고    scopus 로고
    • Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: A 12-week multicenter randomized double-blind controlled trial
    • Huijgen R, Abbink EJ, Bruckert E, et al. Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial. Clin Ther 2010;32(4): 615-25
    • (2010) Clin Ther , vol.32 , Issue.4 , pp. 615-625
    • Huijgen, R.1    Abbink, E.J.2    Bruckert, E.3
  • 127
    • 84855954546 scopus 로고    scopus 로고
    • Efficacy and Safety of Coadministration of Rosuvastatin, Ezetimibe, and Colestimide in Heterozygous Familial Hypercholesterolemia
    • Kawashiri M-A, Nohara A, Noguchi T, et al. Efficacy and Safety of Coadministration of Rosuvastatin, Ezetimibe, and Colestimide in Heterozygous Familial Hypercholesterolemia. Am J Cardiol 2012;109(3):364-9
    • (2012) Am J Cardiol , vol.109 , Issue.3 , pp. 364-369
    • Kawashiri, M.-A.1    Nohara, A.2    Noguchi, T.3
  • 128
    • 66349126280 scopus 로고    scopus 로고
    • PCSK9: A convertase that coordinates LDL catabolism
    • Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res 2009;50(Suppl): S172-7
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 129
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 REGN727/SAR236553 to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
    • Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet 2012;380(9836):29-36
    • (2012) Lancet , vol.380 , Issue.9836 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3
  • 130
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • Roth EM, McKenney JM, Hanotin C, et al. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 2012;367(20):1891-900
    • (2012) N Engl J Med , vol.367 , Issue.20 , pp. 1891-1900
    • Roth, E.M.1    McKenney, J.M.2    Hanotin, C.3
  • 131
    • 84863455703 scopus 로고    scopus 로고
    • Effects of AMG 145, a fully human monoclonal antibody against PCSK9, on low-density lipoprotein cholesterol in subjects taking statins: A phase 1, randomized, double-blind, placebo-controlled, ascending multiple-dose study
    • E1379-9
    • Dias C, Shaywitz A, Cooke B, et al. Effects of AMG 145, a fully human monoclonal antibody against PCSK9, on low-density lipoprotein cholesterol in subjects taking statins: a phase 1, randomized, double-blind, placebo-controlled, ascending multiple-dose study. J Am Coll Cardiol 2012;59(13s1):E1379-9
    • (2012) J Am Coll Cardiol , vol.59 , Issue.13
    • Dias, C.1    Shaywitz, A.2    Cooke, B.3
  • 132
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano RP, Desai NR, Kohli P, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet 2012;380:2007-17
    • (2012) Lancet , vol.380 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3
  • 133
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 2012;380: 1995-2006
    • (2012) Lancet , vol.380 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3
  • 134
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145 a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemiaclinical perspective the reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial
    • Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemiaclinical perspective the reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial. Circulation 2012;126(20):2408-17
    • (2012) Circulation , vol.126 , Issue.20 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3
  • 135
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS Randomized Trial AMG145 in statin-intolerant patients
    • Sullivan D, Olsson AG, Scott R, et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS Randomized Trial AMG145 in statin-intolerant patients. JAMA 2012;308(23):2497-506
    • (2012) JAMA , vol.308 , Issue.23 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3
  • 136
    • 84875939094 scopus 로고    scopus 로고
    • The potential use of monoclonal antibodies and other novel agents as drugs to lower LDL cholesterol
    • Blom DJ, Marais AD, Raal FJ, Lambert G. The potential use of monoclonal antibodies and other novel agents as drugs to lower LDL cholesterol. Clin Lipidol 2013;8(2): 243-56
    • (2013) Clin Lipidol , vol.8 , Issue.2 , pp. 243-256
    • Blom, D.J.1    Marais, A.D.2    Raal, F.J.3    Lambert, G.4
  • 137
    • 77952684555 scopus 로고    scopus 로고
    • Strong induction of PCSK9 gene expression through HNF1a and SREBP2: Mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
    • Dong B, Wu M, Li H, et al. Strong induction of PCSK9 gene expression through HNF1a and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. J Lipid Res 2010;51(6):1486-95
    • (2010) J Lipid Res , vol.51 , Issue.6 , pp. 1486-1495
    • Dong, B.1    Wu, M.2    Li, H.3
  • 138
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • Welder G, Zineh I, Pacanowski MA, et al. High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res 2010;51(9): 2714-21
    • (2010) J Lipid Res , vol.51 , Issue.9 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3
  • 139
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc G, Chamberland A, Wassef H, et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004;24(8):1454-9
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.8 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3
  • 140
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • Kastelein JJP, Wedel MK, Baker BF, et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006;114(16):1729-35
    • (2006) Circulation , vol.114 , Issue.16 , pp. 1729-1735
    • Jjp, K.1    Wedel, M.K.2    Baker, B.F.3
  • 141
    • 77950332314 scopus 로고    scopus 로고
    • Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy
    • Akdim F, Stroes ESG, Sijbrands EJG, et al. Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy. J Am Coll Cardiol 2010;55(15):1611-18
    • (2010) J Am Coll Cardiol , vol.55 , Issue.15 , pp. 1611-1618
    • Akdim, F.1    Esg, S.2    Ejg, S.3
  • 142
    • 77951072532 scopus 로고    scopus 로고
    • Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
    • Visser ME, Akdim F, Tribble DL, et al. Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J Lipid Res 2010;51(5):1057-62
    • (2010) J Lipid Res , vol.51 , Issue.5 , pp. 1057-1062
    • Visser, M.E.1    Akdim, F.2    Tribble, D.L.3
  • 143
    • 77951069859 scopus 로고    scopus 로고
    • Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia
    • Akdim F, Visser ME, Tribble DL, et al. Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia. Am J Cardiol 2010;105(10):1413-19
    • (2010) Am J Cardiol , vol.105 , Issue.10 , pp. 1413-1419
    • Akdim, F.1    Visser, M.E.2    Tribble, D.L.3
  • 144
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen an apolipoprotein B synthesis inhibitor for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised double-blind placebo-controlled trial
    • Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 2010; 375(9719):998-1006
    • (2010) Lancet , vol.375 , Issue.9719 , pp. 998-1006
    • Raal, F.J.1    Santos, R.D.2    Blom, D.J.3
  • 145
    • 84860615159 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: A randomized, double-blind, placebo-controlled trial
    • Visser ME, Wagener G, Baker BF, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial. Eur Heart J 2012; 33(9):1142-9
    • (2012) Eur Heart J , vol.33 , Issue.9 , pp. 1142-1149
    • Visser, M.E.1    Wagener, G.2    Baker, B.F.3
  • 146
    • 79959661095 scopus 로고    scopus 로고
    • Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia
    • Akdim F, Tribble DL, Flaim JD, et al. Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia. Eur Heart J 2011;32(21): 2650-9
    • (2011) Eur Heart J , vol.32 , Issue.21 , pp. 2650-2659
    • Akdim, F.1    Tribble, D.L.2    Flaim, J.D.3
  • 147
    • 84877581057 scopus 로고    scopus 로고
    • Emerging LDL therapies: Microsomal triglyceride transfer protein inhibitors
    • Goldberg AC. Emerging LDL therapies: microsomal triglyceride transfer protein inhibitors. J Clin Lipidol 2013;7(3): S16-20
    • (2013) J Clin Lipidol , vol.7 , Issue.3
    • Goldberg, A.C.1
  • 148
    • 84870409612 scopus 로고    scopus 로고
    • Mipomersen: Evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia
    • Parhofer KG. Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia. Core Evid 2012;7:29-38
    • (2012) Core Evid , vol.7 , pp. 29-38
    • Parhofer, K.G.1
  • 149
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 2007; 356(2):148-56
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 150
    • 84871945617 scopus 로고    scopus 로고
    • Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study
    • Cuchel M, Meagher EA, du Toit Theron H, et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 2013; 381(9860):40-6
    • (2013) Lancet , vol.381 , Issue.9860 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    Du Toit Theron, H.3
  • 151
    • 84896786524 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia
    • Epub ahead of print]
    • Tuteja S, Duffy D, Dunbar RL, et al. Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia. Pharmacotherapy 2013. [Epub ahead of print]
    • (2013) Pharmacotherapy
    • Tuteja, S.1    Duffy, D.2    Dunbar, R.L.3
  • 152
    • 84867581634 scopus 로고    scopus 로고
    • LDL-apheresis affects markers of endothelial function in patients with homozygous familial hypercholesterolemia
    • Nenseter MS, Bogsrud MP, Græsdal A, et al. LDL-apheresis affects markers of endothelial function in patients with homozygous familial hypercholesterolemia. Thromb Res 2012;130(5):823-5
    • (2012) Thromb Res , vol.130 , Issue.5 , pp. 823-825
    • Nenseter, M.S.1    Bogsrud, M.P.2    Græsdal, A.3
  • 153
    • 84864284823 scopus 로고    scopus 로고
    • Apheresis in homozygous familial hypercholesterolemia: The results of a follow-up of all Norwegian patients with homozygous familial hypercholesterolemia
    • Græsdal A, Bogsrud MP, Holven KB, et al. Apheresis in homozygous familial hypercholesterolemia: the results of a follow-up of all Norwegian patients with homozygous familial hypercholesterolemia. J Clin Lipidol 2012;6(4):331-9
    • (2012) J Clin Lipidol , vol.6 , Issue.4 , pp. 331-339
    • Græsdal, A.1    Bogsrud, M.P.2    Holven, K.B.3
  • 154
    • 0034279879 scopus 로고    scopus 로고
    • Role of orthotopic liver transplant in the treatment of homozygous familial hypercholesterolemia
    • Castilla Cabezas JA, López-Cillero P, Jiménez J, et al. Role of orthotopic liver transplant in the treatment of homozygous familial hypercholesterolemia. Rev Esp Enferm Dig 2000;92(9):601-8
    • (2000) Rev Esp Enferm Dig , vol.92 , Issue.9 , pp. 601-608
    • Castilla Cabezas, J.A.1    López-Cillero, P.2    Jiménez, J.3
  • 155
    • 12944286628 scopus 로고    scopus 로고
    • Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to-side portocaval shunt and ileal bypass
    • Lopez-Santamaria M, Migliazza L, Gamez M, et al. Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to-side portocaval shunt and ileal bypass. J Pediatr Surg 2000;35(4):630-3
    • (2000) J Pediatr Surg , vol.35 , Issue.4 , pp. 630-633
    • Lopez-Santamaria, M.1    Migliazza, L.2    Gamez, M.3
  • 156
    • 70249103543 scopus 로고    scopus 로고
    • Liver transplantation for homozygous familial hypercholesterolemia: Two case reports
    • Kakaei F, Nikeghbalian S, Kazemi K, et al. Liver transplantation for homozygous familial hypercholesterolemia: two case reports. Transplant Proc 2009;41(7): 2939-41
    • (2009) Transplant Proc , vol.41 , Issue.7 , pp. 2939-2941
    • Kakaei, F.1    Nikeghbalian, S.2    Kazemi, K.3
  • 157
    • 79951701629 scopus 로고    scopus 로고
    • Preemptive liver transplantation in a child with familial hypercholesterolemia
    • Maiorana A, Nobili V, Calandra S, et al. Preemptive liver transplantation in a child with familial hypercholesterolemia. Pediatr Transplant 2011;15(2):E25-9
    • (2011) Pediatr Transplant , vol.15 , Issue.2
    • Maiorana, A.1    Nobili, V.2    Calandra, S.3
  • 158
    • 84857639583 scopus 로고    scopus 로고
    • Treatment of familial hypercholesterolemia: Is there a need beyond statin therapy?
    • Raper A, Kolansky DM, Cuchel M. Treatment of familial hypercholesterolemia: is there a need beyond statin therapy? Curr Atheroscler Rep 2012;14(1):11-16
    • (2012) Curr Atheroscler Rep , vol.14 , Issue.1 , pp. 11-16
    • Raper, A.1    Kolansky, D.M.2    Cuchel, M.3
  • 159
    • 84876003260 scopus 로고    scopus 로고
    • Diagnosis and treatment of familial hypercholesterolaemia
    • Hovingh GK, Davidson MH, Kastelein JJP, O'Connor AM. Diagnosis and treatment of familial hypercholesterolaemia. Eur Heart J 2013;34(13):962-71
    • (2013) Eur Heart J , vol.34 , Issue.13 , pp. 962-971
    • Hovingh, G.K.1    Davidson, M.H.2    Jjp, K.3    O'Connor, A.M.4
  • 160
    • 73549097512 scopus 로고    scopus 로고
    • Genetic variants associated with Lp (a) lipoprotein level and coronary disease
    • Clarke R, Peden JF, Hopewell JC, et al. Genetic variants associated with Lp (a) lipoprotein level and coronary disease. N Engl J Med 2009;361(26):2518-28
    • (2009) N Engl J Med , vol.361 , Issue.26 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3
  • 162
    • 0010965565 scopus 로고
    • Partial amino acid sequence of apolipoprotein (a) shows that it is homologous to plasminogen
    • Eaton DL, Fless GM, Kohr WJ, et al. Partial amino acid sequence of apolipoprotein (a) shows that it is homologous to plasminogen. Proc Natl Acad Sci USA 1987;84(10):3224-8
    • (1987) Proc Natl Acad Sci USA , vol.84 , Issue.10 , pp. 3224-3228
    • Eaton, D.L.1    Fless, G.M.2    Kohr, W.J.3
  • 163
    • 53149102508 scopus 로고    scopus 로고
    • The role of oxidized phospholipids in mediating lipoprotein (a) atherogenicity
    • Tsimikas S, Witztum JL. The role of oxidized phospholipids in mediating lipoprotein (a) atherogenicity. Curr Opin Lipidol 2008;19(4):369-77
    • (2008) Curr Opin Lipidol , vol.19 , Issue.4 , pp. 369-377
    • Tsimikas, S.1    Witztum, J.L.2
  • 164
    • 21444447949 scopus 로고    scopus 로고
    • Oxidized phospholipids, Lp (a) lipoprotein, and coronary artery disease
    • Tsimikas S, Brilakis ES, Miller ER, et al. Oxidized phospholipids, Lp (a) lipoprotein, and coronary artery disease. N Engl J Med 2005;353(1):46-57
    • (2005) N Engl J Med , vol.353 , Issue.1 , pp. 46-57
    • Tsimikas, S.1    Brilakis, E.S.2    Miller, E.R.3
  • 165
    • 65349142018 scopus 로고    scopus 로고
    • Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: Results from the Dallas Heart Study
    • Tsimikas S, Clopton P, Brilakis ES, et al. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation 2009; 119(13):1711-19
    • (2009) Circulation , vol.119 , Issue.13 , pp. 1711-1719
    • Tsimikas, S.1    Clopton, P.2    Brilakis, E.S.3
  • 166
    • 0026667073 scopus 로고
    • Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations
    • Boerwinkle E, Leffert CC, Lin J, et al. Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations. J Clin Investig 1992;90(1):52-60
    • (1992) J Clin Investig , vol.90 , Issue.1 , pp. 52-60
    • Boerwinkle, E.1    Leffert, C.C.2    Lin, J.3
  • 167
    • 77952487856 scopus 로고    scopus 로고
    • Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein (a) in South Asians Chinese and European Caucasians
    • Lanktree MB, Anand SS, Yusuf S, Hegele RA. Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein (a) in South Asians, Chinese, and European Caucasians. Circ Cardiovasc Genet 2010; 3(1):39-46
    • (2010) Circ Cardiovasc Genet , vol.3 , Issue.1 , pp. 39-46
    • Lanktree, M.B.1    Anand, S.S.2    Yusuf, S.3    Hegele, R.A.4
  • 168
    • 84884921908 scopus 로고    scopus 로고
    • Enhanced proinflammatory state and autoimmune activation: A breakthrough to understanding chronic diseases
    • Epub ahead of print]
    • Onat A, Can G. Enhanced proinflammatory state and autoimmune activation: a breakthrough to understanding chronic diseases. Curr Pharm Des 2013. [Epub ahead of print]
    • (2013) Curr Pharm des
    • Onat, A.1    Can, G.2
  • 169
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: Current status
    • Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 2010; 31(23):2844-53
    • (2010) Eur Heart J , vol.31 , Issue.23 , pp. 2844-2853
    • Nordestgaard, B.G.1    Chapman, M.J.2    Ray, K.3
  • 170
    • 80053914425 scopus 로고    scopus 로고
    • Clinical utility of inflammatory markers and advanced lipoprotein testing: Advice from an expert panel of lipid specialists
    • Davidson MH, Ballantyne CM, Jacobson TA, et al. Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J Clin Lipidol 2011;5(5):338-67
    • (2011) J Clin Lipidol , vol.5 , Issue.5 , pp. 338-367
    • Davidson, M.H.1    Ballantyne, C.M.2    Jacobson, T.A.3
  • 171
    • 0043169544 scopus 로고    scopus 로고
    • Long term statin treatment reduces lipoprotein (a) concentrations in heterozygous familial hypercholesterolaemia
    • Van Wissen S, Smilde TJ, Trip MD, et al. Long term statin treatment reduces lipoprotein (a) concentrations in heterozygous familial hypercholesterolaemia. Heart 2003;89(8):893-6
    • (2003) Heart , vol.89 , Issue.8 , pp. 893-896
    • Van Wissen, S.1    Smilde, T.J.2    Trip, M.D.3
  • 172
    • 84896775327 scopus 로고    scopus 로고
    • Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: An analysis from the JUPITER Trial
    • Epub ahead of print]
    • Khera AV, Everett BM, Caulfield MP, et al. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial. Circulation 2013. [Epub ahead of print]
    • (2013) Circulation
    • Khera, A.V.1    Everett, B.M.2    Caulfield, M.P.3
  • 173
    • 0024466520 scopus 로고
    • Pronounced lowering of serum levels of lipoprotein Lp (a) in hyperlipidaemic subjects treated with nicotinic acid
    • Carlson LA, Hamsten A, Asplund A, Pronounced lowering of serum levels of lipoprotein Lp (a) in hyperlipidaemic subjects treated with nicotinic acid. J Intern Med 1989;226(4):271-6
    • (1989) J Intern Med , vol.226 , Issue.4 , pp. 271-276
    • Carlson, L.A.1    Hamsten, A.2    Asplund, A.3
  • 174
    • 84867364520 scopus 로고    scopus 로고
    • Nicotinic acid inhibits hepatic APOA gene expression: Studies in humans and in transgenic mice
    • Chennamsetty I, Kostner KM, Claudel T, et al. Nicotinic acid inhibits hepatic APOA gene expression: Studies in humans and in transgenic mice. J Lipid Res 2012; 53(11):2405-12
    • (2012) J Lipid Res , vol.53 , Issue.11 , pp. 2405-2412
    • Chennamsetty, I.1    Kostner, K.M.2    Claudel, T.3
  • 175
    • 84886070404 scopus 로고    scopus 로고
    • Relationship of apolipoproteins A-1 and B, and lipoprotein (a) to cardiovascular outcomes the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes)
    • Albers JJ, Slee A, O'Brien KD, et al. Relationship of apolipoproteins A-1 and B, and lipoprotein (a) to cardiovascular outcomes the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglyceride and Impact on Global Health Outcomes). J Am Coll Cardiol 2013; 62(17):1575-9
    • (2013) J Am Coll Cardiol , vol.62 , Issue.17 , pp. 1575-1579
    • Albers, J.J.1    Slee, A.2    O'Brien, K.D.3
  • 176
    • 84896767843 scopus 로고    scopus 로고
    • Effect of Nicotinic acid/Laropiprant in the lipoprotein(a) concentration with regard to baseline lipoprotein(a) concentration and LPA genotype
    • Epub ahead of print]
    • Cenarro A, Puzo J, Ferrando J, et al. Effect of Nicotinic acid/Laropiprant in the lipoprotein(a) concentration with regard to baseline lipoprotein(a) concentration and LPA genotype. Metabolism 2013. [Epub ahead of print]
    • (2013) Metabolism
    • Cenarro, A.1    Puzo, J.2    Ferrando, J.3
  • 177
    • 18544390540 scopus 로고    scopus 로고
    • Effect of aspirin treatment on serum concentrations of lipoprotein (a) in patients with atherosclerotic diseases
    • Akaike M, Azuma H, Kagawa A, et al. Effect of aspirin treatment on serum concentrations of lipoprotein (a) in patients with atherosclerotic diseases. Clin Chem 2002;48(9):1454-9
    • (2002) Clin Chem , vol.48 , Issue.9 , pp. 1454-1459
    • Akaike, M.1    Azuma, H.2    Kagawa, A.3
  • 178
    • 34548383493 scopus 로고    scopus 로고
    • Effect of aspirin on lipoprotein (a) in patients with ischemic stroke
    • Ranga GS, Kalra OP, Tandon H, et al. Effect of aspirin on lipoprotein (a) in patients with ischemic stroke. J Stroke Cerebrovasc Dis 2007;16(5):220-4
    • (2007) J Stroke Cerebrovasc Dis , vol.16 , Issue.5 , pp. 220-224
    • Ranga, G.S.1    Kalra, O.P.2    Tandon, H.3
  • 179
    • 0033607536 scopus 로고    scopus 로고
    • Aspirin reduces apolipoprotein (a)(apo (a)) production in human hepatocytes by suppression of apo (a) gene transcription
    • Kagawa A, Azuma H, Akaike M, et al. Aspirin reduces apolipoprotein (a)(apo (a)) production in human hepatocytes by suppression of apo (a) gene transcription. J Biol Chem 1999;274(48):34111-15
    • (1999) J Biol Chem , vol.274 , Issue.48 , pp. 34111-34115
    • Kagawa, A.1    Azuma, H.2    Akaike, M.3
  • 180
    • 0032417890 scopus 로고    scopus 로고
    • Lipoprotein (a), lipids, aspirin, and risk of myocardial infarction in the Physician's Health Study
    • Ariyo A, Hennekens CH, Stampfer MJ, Ridker PM. Lipoprotein (a), lipids, aspirin, and risk of myocardial infarction in the Physician's Health Study. J Cardiovasc Risk 1998;5(4):273-8
    • (1998) J Cardiovasc Risk , vol.5 , Issue.4 , pp. 273-278
    • Ariyo, A.1    Hennekens, C.H.2    Stampfer, M.J.3    Ridker, P.M.4
  • 181
    • 84896776402 scopus 로고    scopus 로고
    • AMG 145, a monoclonal antibody against PCSK9, significantly reduces lipoprotein (a) in hypercholesterolemic patients receiving statin therapy: An analysis from the LAPLACE-TIMI 57 Trial
    • Epub ahead of print]
    • Desai NR, Kohli P, Giugliano RP, et al. AMG 145, a monoclonal antibody against PCSK9, significantly reduces lipoprotein (a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LAPLACE-TIMI 57 Trial. Circulation 2013. [Epub ahead of print]
    • (2013) Circulation
    • Desai, N.R.1    Kohli, P.2    Giugliano, R.P.3
  • 182
    • 61549101898 scopus 로고    scopus 로고
    • Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein (a) levels and prevent major adverse coronary events
    • Jaeger BR, Richter Y, Nagel D, et al. Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein (a) levels and prevent major adverse coronary events. Nat Clin Pract Cardiovasc Med 2009;6(3): 229-39
    • (2009) Nat Clin Pract Cardiovasc Med , vol.6 , Issue.3 , pp. 229-239
    • Jaeger, B.R.1    Richter, Y.2    Nagel, D.3
  • 183
    • 84857923378 scopus 로고    scopus 로고
    • Low-density lipoprotein apheresis is effective in reducing lipoprotein (a) levels and in improving symptoms in a patient with refractory angina secondary to accelerated coronary artery disease
    • Ibrahim M, Ussen B, Pottle A, Barbir M. Low-density lipoprotein apheresis is effective in reducing lipoprotein (a) levels and in improving symptoms in a patient with refractory angina secondary to accelerated coronary artery disease. J Clin Lipidol 2012; 6(2):192-4
    • (2012) J Clin Lipidol , vol.6 , Issue.2 , pp. 192-194
    • Ibrahim, M.1    Ussen, B.2    Pottle, A.3    Barbir, M.4
  • 184
    • 84890904215 scopus 로고    scopus 로고
    • Lipoprotein apheresis in patients with maximally tolerated lipid lowering therapy Lp(a)-hyperlipoproteinemia and progressive cardiovascular disease: Prospective Observational Multicenter Study
    • Leebmann J, Roseler E, Julius U, et al. Lipoprotein apheresis in patients with maximally tolerated lipid lowering therapy, Lp(a)-hyperlipoproteinemia and progressive cardiovascular disease: prospective Observational Multicenter Study. Circulation 2013;128(24):2567-76
    • (2013) Circulation , vol.128 , Issue.24 , pp. 2567-2576
    • Leebmann, J.1    Roseler, E.2    Julius, U.3
  • 185
    • 84872876060 scopus 로고    scopus 로고
    • Effect of specific lipoprotein(a) apheresis on coronary atherosclerosis regression assessed by quantitative coronary angiography
    • Safarova MS, Ezhov MV, Afanasieva OI, et al. Effect of specific lipoprotein(a) apheresis on coronary atherosclerosis regression assessed by quantitative coronary angiography. Atheroscler Suppl 2013;14(1): 93-9
    • (2013) Atheroscler Suppl , vol.14 , Issue.1 , pp. 93-99
    • Safarova, M.S.1    Ezhov, M.V.2    Afanasieva, O.I.3
  • 186
    • 0037945488 scopus 로고    scopus 로고
    • The effect of L-carnitine on plasma lipoprotein (a) levels in hypercholesterolemic patients with type 2 diabetes mellitus
    • Derosa G, Cicero AFG, Gaddi A, et al. The effect of L-carnitine on plasma lipoprotein (a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25(5):1429-39
    • (2003) Clin Ther , vol.25 , Issue.5 , pp. 1429-1439
    • Derosa, G.1    Afg, C.2    Gaddi, A.3
  • 187
    • 0034303187 scopus 로고    scopus 로고
    • L-carnitine reduces plasma lipoprotein (a) levels in patients with hyper Lp (a)
    • Sirtori CR, Calabresi L, Ferrara S, et al. L-carnitine reduces plasma lipoprotein (a) levels in patients with hyper Lp (a). Nutr Metab Cardiovasc Dis 2000;10(5): 247-51
    • (2000) Nutr Metab Cardiovasc Dis , vol.10 , Issue.5 , pp. 247-251
    • Sirtori, C.R.1    Calabresi, L.2    Ferrara, S.3
  • 188
    • 77958600062 scopus 로고    scopus 로고
    • Effects of l-carnitine supplement on serum inflammatory cytokines C-reactive protein lipoprotein (a) and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia
    • Shakeri A, Tabibi H, Hedayati M. Effects of l-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Hemodial Int 2010; 14(4):498-504
    • (2010) Hemodial Int , vol.14 , Issue.4 , pp. 498-504
    • Shakeri, A.1    Tabibi, H.2    Hedayati, M.3
  • 189
    • 0027724204 scopus 로고
    • Metabolic effects of converting enzyme inhibitors: Focus on the reduction of cholesterol and lipoprotein (a) by fosinopril
    • Schlueter W, Keilani T, Batlle DC. Metabolic effects of converting enzyme inhibitors: focus on the reduction of cholesterol and lipoprotein (a) by fosinopril. Am J Cardiol 1993;72(20):H37-44
    • (1993) Am J Cardiol , vol.72 , Issue.20
    • Schlueter, W.1    Keilani, T.2    Batlle, D.C.3
  • 190
    • 0029876659 scopus 로고    scopus 로고
    • Testosterone-induced suppression of lipoprotein(a) in normal men; Relation to basal lipoprotein(a) level
    • Marcovina SM, Lippi G, Bagatell CJ, Bremner WJ. Testosterone-induced suppression of lipoprotein(a) in normal men; relation to basal lipoprotein(a) level. Atherosclerosis 1996;122(1):89-95
    • (1996) Atherosclerosis , vol.122 , Issue.1 , pp. 89-95
    • Marcovina, S.M.1    Lippi, G.2    Bagatell, C.J.3    Bremner, W.J.4
  • 192
    • 0028170829 scopus 로고
    • Tamoxifen and estrogen lower circulating lipoprotein (a) concentrations in healthy postmenopausal women
    • Shewmon DA, Stock JL, Rosen CJ, et al. Tamoxifen and estrogen lower circulating lipoprotein (a) concentrations in healthy postmenopausal women. Arterioscler Thromb Vasc Biol 1994;14(10):1586-93
    • (1994) Arterioscler Thromb Vasc Biol , vol.14 , Issue.10 , pp. 1586-1593
    • Shewmon, D.A.1    Stock, J.L.2    Rosen, C.J.3
  • 193
    • 0032539907 scopus 로고    scopus 로고
    • Effect of postmenopausal hormone therapy on lipoprotein (a) concentration
    • Espeland MA, Marcovina SM, Miller V, et al. Effect of postmenopausal hormone therapy on lipoprotein (a) concentration. Circulation 1998;97(10):979-86
    • (1998) Circulation , vol.97 , Issue.10 , pp. 979-986
    • Espeland, M.A.1    Marcovina, S.M.2    Miller, V.3
  • 194
    • 0242577778 scopus 로고    scopus 로고
    • A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women
    • Müller H, Lindman AS, Blomfeldt A, et al. A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women. J Nutr 2003; 133(11):3422-7
    • (2003) J Nutr , vol.133 , Issue.11 , pp. 3422-3427
    • Müller, H.1    Lindman, A.S.2    Blomfeldt, A.3
  • 195
    • 0030342489 scopus 로고    scopus 로고
    • Lipoprotein (a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy
    • Yildirimkaya M, Ozata M, Yilmaz K, et al. Lipoprotein (a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy. Endocr J 1996; 43(6):731-6
    • (1996) Endocr J , vol.43 , Issue.6 , pp. 731-736
    • Yildirimkaya, M.1    Ozata, M.2    Yilmaz, K.3
  • 196
    • 0038185181 scopus 로고    scopus 로고
    • Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism: Effect of treatment with levothyroxine
    • Milionis HJ, Efstathiadou Z, Tselepis AD, et al. Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism: effect of treatment with levothyroxine. Thyroid 2003;13(4):365-9
    • (2003) Thyroid , vol.13 , Issue.4 , pp. 365-369
    • Milionis, H.J.1    Efstathiadou, Z.2    Tselepis, A.D.3
  • 197
    • 0028908938 scopus 로고
    • Changes in serum lipoprotein (a) and lipids during treatment of hyperthyroidism
    • Kung AW, Pang RW, Lauder I, et al. Changes in serum lipoprotein (a) and lipids during treatment of hyperthyroidism. Clin Chem 1995;41(2):226-31
    • (1995) Clin Chem , vol.41 , Issue.2 , pp. 226-231
    • Kung, A.W.1    Pang, R.W.2    Lauder, I.3
  • 198
    • 0031686061 scopus 로고    scopus 로고
    • Effect of thyroid hormone replacement on lipoprotein (a), lipids, and apolipoproteins in subjects with hypothyroidism
    • Triguero MLM, Hernández-Mijares A, Nguyen TT, et al. Effect of thyroid hormone replacement on lipoprotein (a), lipids, and apolipoproteins in subjects with hypothyroidism. Mayo Clin Proc 1998;73: 837-41
    • (1998) Mayo Clin Proc , vol.73 , pp. 837-841
    • Mlm, T.1    Hernández-Mijares, A.2    Nguyen, T.T.3
  • 199
    • 84878892697 scopus 로고    scopus 로고
    • LDL cholesterol goals in high-risk patients: How low do we go and how do we get there?
    • Besseling J, van Capelleveen J, Kastelein JJ, Hovingh GK. LDL cholesterol goals in high-risk patients: how low do we go and how do we get there? Drugs 2013;73: 293-301
    • (2013) Drugs , vol.73 , pp. 293-301
    • Besseling, J.1    Van Capelleveen, J.2    Kastelein, J.J.3    Hovingh, G.K.4
  • 200
    • 84896795932 scopus 로고    scopus 로고
    • Lipoprotein (a): The underestimated cardiovascular risk factor
    • Epub ahead of print]
    • Thompson GR, Seed M. Lipoprotein (a): the underestimated cardiovascular risk factor. Heart 2013. [Epub ahead of print]
    • (2013) Heart
    • Thompson, G.R.1    Seed, M.2
  • 201
    • 80052380574 scopus 로고    scopus 로고
    • Farnesoid X receptor represses hepatic human APOA gene expression
    • Chennamsetty I, Claudel T, Kostner KM, et al. Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Investig 2011;121(9):3724-34
    • (2011) J Clin Investig , vol.121 , Issue.9 , pp. 3724-3734
    • Chennamsetty, I.1    Claudel, T.2    Kostner, K.M.3
  • 202
    • 0032480779 scopus 로고    scopus 로고
    • Novel therapeutic strategy for atherosclerosis: Ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression
    • Morishita R, Yamada S, Yamamoto K, et al. Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression. Circulation 1998;98(18): 1898-904
    • (1998) Circulation , vol.98 , Issue.18 , pp. 1898-1904
    • Morishita, R.1    Yamada, S.2    Yamamoto, K.3
  • 203
    • 79953699040 scopus 로고    scopus 로고
    • Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice
    • Merki E, Graham M, Taleb A, et al. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J Am Coll Cardiol 2011;57(15):1611-21
    • (2011) J Am Coll Cardiol , vol.57 , Issue.15 , pp. 1611-1621
    • Merki, E.1    Graham, M.2    Taleb, A.3
  • 204
    • 70350292362 scopus 로고    scopus 로고
    • Bile-acid-activated receptors: Targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
    • Fiorucci S, Mencarelli A, Palladino G, Cipriani S. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci 2009;30(11):570-80
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.11 , pp. 570-580
    • Fiorucci, S.1    Mencarelli, A.2    Palladino, G.3    Cipriani, S.4
  • 205
    • 65349090763 scopus 로고    scopus 로고
    • A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia
    • Evans MJ, Mahaney PE, Borges-Marcucci L, et al. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol 2009;296(3): G543-52
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , Issue.3
    • Evans, M.J.1    Mahaney, P.E.2    Borges-Marcucci, L.3
  • 206
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013;145(3): 574-82.e571
    • (2013) Gastroenterology , vol.145 , Issue.3
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.