Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Gao, Xuxia ^a   Cao, Yanna ^a,b   Staloch, Dustin A ^a   Gonzales, Michael A ^a   Aronson, Judith F ^b   Chao, Celia ^b   Hellmich, Mark R ^b   Ko, Tien C ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; CD45 ANTIGEN; CERULETIDE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROGENIC FUNCTION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE COURSE; HETEROZYGOSITY; HOMOZYGOSITY; INSULIN BLOOD LEVEL; LEUKOCYTE; MALE; MOUSE; NONHUMAN; PANCREATIC STELLATE CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; CHEMICALLY INDUCED; FIBROSIS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PANCREAS; PANCREAS DISEASE; PATHOLOGY; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; CERULETIDE; FIBROSIS; MICE; MICE, KNOCKOUT; PANCREAS; PANCREATIC DISEASES; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

EID: 84896767900     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089114     Document Type: Article

References (36)

1. Shrikhande SV, Martignoni ME, Shrikhande M, Kappeler A, Ramesh H, et al. (2003) Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis. Br J Surg 90: 1565-1572. (Pubitemid 37533175)
2. Spanier BW, Dijkgraaf MG, Bruno MJ (2008) Trends and forecasts of hospital admissions for acute and chronic pancreatitis in the Netherlands. Eur J Gastroenterol Hepatol 20: 653-658.
3. Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471. (Pubitemid 28013118)
4. Shek FW, Benyon RC, Walker FM, McCrudden PR, Pender SL, et al. (2002) Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 160: 1787-1798. (Pubitemid 34525658)
5. Tarantal AF, Chen H, Shi TT, Lu CH, Fang AB, et al. (2010) Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J 36: 907-914.
6. Wang B, Komers R, Carew R, Winbanks CE, Xu B, et al. (2012) Suppression of microRNA-29 expression by TGF-beta1 promotes collagen expression and renal fibrosis. J Am Soc Nephrol 23: 252-265.
7. Yang L, Inokuchi S, Roh YS, Song J, Loomba R, et al. (2013) Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology 144: 1042-1054 e1044.
8. Kordes C, Brookmann S, Haussinger D, Klonowski-Stumpe H (2005) Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells. Pancreas 31: 156-167. (Pubitemid 41077145)
9. Vogelmann R, Ruf D, Wagner M, Adler G, Menke A (2001) Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model. Am J Physiol Gastrointest Liver Physiol 280: G164-172.
10. Xu B, Chen H, Xu W, Zhang W, Buckley S, et al. (2012) Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol 303: L89-96.
11. Aoki H, Ohnishi H, Hama K, Shinozaki S, Kita H, et al. (2006) Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. J Cell Biochem 99: 221-228. (Pubitemid 44297966)
12. Aoki H, Ohnishi H, Hama K, Ishijima T, Satoh Y, et al. (2006) Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am J Physiol Cell Physiol 290: C1100-1108.
13. Ahnfelt-Ronne J, Ravassard P, Pardanaud-Glavieux C, Scharfmann R, Serup P (2010) Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development. Diabetes 59: 1948-1956.
14. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, et al. (2004) TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol 266: 285-298. (Pubitemid 38102239)
15. Shu B, Zhang M, Xie R, Wang M, Jin H, et al. (2011) BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci 124: 3428-3440.
16. Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221: 249-258. (Pubitemid 30253588)
17. Yang YL, Ju HZ, Liu SF, Lee TC, Shih YW, et al. (2011) BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition. J Cell Biochem 112: 2558-2565.
18. Yang YL, Liu YS, Chuang LY, Guh JY, Lee TC, et al. (2009) Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology 150: 727-740.
19. Shlyonsky V, Soussia IB, Naeije R, Mies F (2011) Opposing effects of bone morphogenetic protein-2 and endothelin-1 on lung fibroblast chloride currents. Am J Respir Cell Mol Biol 45: 1154-1160.
20. Wang S, Sun A, Li L, Zhao G, Jia J, et al. (2012) Up-regulation of BMP-2 antagonizes TGF-beta1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med 16: 2301-2310.
21. Gao X, Cao Y, Yang W, Duan C, Aronson JF, et al. (2013) BMP2 inhibits TGF-beta-induced pancreatic stellate cell activation and extracellular matrix formation. Am J Physiol Gastrointest Liver Physiol 304: G804-813.
22. Perides G, Tao X, West N, Sharma A, Steer ML (2005) A mouse model of ethanol dependent pancreatic fibrosis. Gut 54: 1461-1467. (Pubitemid 41375204)
23. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, et al. (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115: 421-432.
24. Cao Y, Chen L, Zhang W, Liu Y, Papaconstantinou HT, et al. (2007) Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach. Am J Physiol Gastrointest Liver Physiol 292: G28-38. (Pubitemid 46090249)
25. Song Y, Jones JE, Beppu H, Keaney JF Jr, Loscalzo J, et al. (2005) Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112: 553-562. (Pubitemid 41060796)
26. Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, et al. (2006) Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 98: 818-827.
27. Ohnishi H, Miyata T, Yasuda H, Satoh Y, Hanatsuka K, et al. (2004) Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions. J Biol Chem 279: 8873-8878. (Pubitemid 38295947)
28. Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M (2013) Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 144: 1199-1209 e1194.
29. Saeki K, Kanai T, Nakano M, Nakamura Y, Miyata N, et al. (2012) CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice. Gastroenterology 142: 1010-1020 e1019.
30. Masamune A, Kikuta K, Watanabe T, Satoh K, Hirota M, et al. (2009) Fibrinogen induces cytokine and collagen production in pancreatic stellate cells. Gut 58: 550-559.
31. Davies RJ, Holmes AM, Deighton J, Long L, Yang X, et al. (2012) BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta in pulmonary artery smooth muscle cells: role of proinflammatory cytokines. Am J Physiol Lung Cell Mol Physiol 302: L604-615.
32. Zhao GQ (2003) Consequences of knocking out BMP signaling in the mouse. Genesis 35: 43-56.
33. Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, et al. (2013) Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology 13: 336-342.
34. Aghdassi AA, Mayerle J, Christochowitz S, Weiss FU, Sendler M, et al. (2011) Animal models for investigating chronic pancreatitis. Fibrogenesis Tissue Repair 4: 26.
35. Yoo BM, Yeo M, Oh TY, Choi JH, Kim WW, et al. (2005) Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 30: e71-79.
36. Wang D, Warner GM, Yin P, Knudsen BE, Cheng J, et al. (2013) Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model. Am J Physiol Renal Physiol 304: F938-947.