Opposing effects of bone morphogenetic protein-2 and endothelin-1 on lung fibroblast chloride currents

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 6, 2011, Pages 1154-1160

  Shlyonsky, Vadim ^a   Soussia, Ismail Ben ^a   Naeije, Robert ^a   Mies, Frédérique ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Chloride channel; Differentiation; Fibroblast; Patch clamp

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN 2; CHLORIDE CHANNEL; ENDOTHELIN 1; LYSOPHOSPHATIDIC ACID; PROTEIN KINASE C;

ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FIBROBLAST CULTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; LUNG FIBROBLAST; MYOFIBROBLAST; WHOLE CELL;

ACTINS; ANTIGENS, DIFFERENTIATION; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; CHLORIDES; ENDOTHELIN-1; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; ION TRANSPORT; PROTEIN KINASE C; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION;

EID: 82755165239     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0443OC     Document Type: Article

References (39)

1. Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, et al. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol 2009;54:S20-S31.
2. Welsh DJ, Harnett M, MacLean M, Peacock AJ. Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter. Am J Respir Crit Care Med 2004;170:252-259. (Pubitemid 38971409)
3. Pak O, Aldashev A, Welsh D, Peacock A. The effects of hypoxia on the cells of the pulmonary vasculature. Eur Respir J 2007;30:364-372. (Pubitemid 47201724)
4. Davies RJ, Morrell NW. Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor. Chest 2008;134:1271-1277.
5. Li S, Tabar SS, Malec V, Eul BG, Klepetko W, Weissmann N, Grimminger F, Seeger W, Rose F, Hänze J. NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxid Redox Signal 2008;10:1687-1698.
6. Stevens T, Phan S, Frid MG, Alvarez D, Herzog E, Stenmark KR. Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts. Proc Am Thorac Soc 2008;5:783-791.
7. Yin Z, Watsky MA. Chloride channel activity in human lung fibroblasts and myofibroblasts. Am J Physiol Lung Cell Mol Physiol 2005;288: L1110-L1116. (Pubitemid 40695436)
8. - current activity and fibroblast-to-myofibroblast differentiation. Am J Physiol Cell Physiol 2008;294:C535-C542.
9. Schneider L, Klausen TK, Stock C, Mally S, Christensen ST, Pedersen SF, Hoffmann EK, Schwab A. H-ras transformation sensitizes volumeactivated anion channels and increases migratory activity of NIH3T3 fibroblasts. Pflugers Arch 2008;455:1055-1062. (Pubitemid 351169982)
10. - channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle. J Cell Physiol 2003;194:376-383.
11. Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004;279:23098-23103. (Pubitemid 38685614)
12. Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou- Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004;15:2707-2719. (Pubitemid 38691860)
13. Shahar I, Fireman E, Topilsky M, Grief J, Schwarz Y, Kivity S, Ben- Efraim S, Spirer Z. Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. Int J Immunopharmacol 1999;21:759-775. (Pubitemid 29472503)
14. Peacock AJ, Dawes KE, Shock A, Gray AJ, Reeves JT, Laurent GJ. Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am J Respir Cell Mol Biol 1992;7:492-499.
15. Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffrè V, Galderisi U, De NardoM, Mastruzzo C, et al. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of MAP kinases. J Cell Biochem 2005;96:858-868. (Pubitemid 41567556)
16. Dawes KE, Peacock AJ, Gray AJ, Bishop JE, Laurent GJ. Characterization of fibroblast mitogens and chemoattractants produced by endothelial cells exposed to hypoxia. Am J Respir Cell Mol Biol 1994;10:552-559.
17. Xiao GN, Guan YY, He H. Effects of Cl channel blockers on endothelin- 1-induced proliferation of rat vascular smooth muscle cells. Life Sci 2002;70:2233-2241. (Pubitemid 34251295)
18. Wang GL, Wang XR, Lin MJ, He H, Lan XJ, Guan YY. Deficiency in ClC-3 chloride channels prevents rat aortic smooth muscle cell proliferation. Circ Res 2002;91:e28-e32.
19. - current via NADPH oxidase and mitochondrial reactive oxygen species. Cardiovasc Res 2010;88:93-100.
20. Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 2001;81:1415-1459. (Pubitemid 32947776)
21. Okada Y, Sato K, Numata T. Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel. J Physiol 2009; 587:2141-2149.
22. Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. Am J Respir Crit Care Med 2008;177:321-329. (Pubitemid 351198376)
23. Yang YL, Liu YS, Chuang LY, Guh JY, Lee TC, Liao TN, Hung MY, Chiang TA. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology 2009;150:727-740.
24. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-tomesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-968. (Pubitemid 36889942)
25. + channel function: an in vitro model. J Biol Chem 2005;280:24181-24187.
26. Alexander R, Grinstein S. Activation of kinases upon volume changes: role in cellular homeostasis. Contrib Nephrol 2006;152:105-124. (Pubitemid 44672104)
27. Lee YS, Chuong CM. Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis. J Cell Physiol 1997;170:153-165.
28. Hay E, Lemonnier J, Fromigue O, Marie PJ. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad independent, protein kinase C-dependent signaling pathway. J Biol Chem 2001;276:29028-29036.
29. McConnell JE, Armstrong JF, Hodges PE, Bard JB. The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. Dev Biol 1995;169:218-228.
30. Jackson D, Zheng Y, Lyo D, Shen Y, Nakayama K, Nakayama KI, Humphries MJ, Reyland ME, Foster DA. Suppression of cell migration by protein kinase Cdelta. Oncogene 2005;24:3067-3072. (Pubitemid 40675540)
31. Pearson JD, DeWald DB, Mathews WR, Mozier NM, Zürcher-Neely HA, Heinrikson RL, Morris MA, McCubbin WD, McDonald JR, Fraser ED, et al. Amino acid sequence and characterization of a protein inhibitor of protein kinase C. J Biol Chem 1990;265:4583-4591. (Pubitemid 20096130)
32. Toker A, Sellers LA, Amess B, Patel Y, Harris A, Aitken A. Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) from sheep brain: amino acid sequence of phosphorylated forms. Eur J Biochem 1992;206:453-461.
33. Aitken A. 14-3-3 proteins: a historic overview. Semin Cancer Biol 2006; 16:162-172. (Pubitemid 43796128)
34. Schwab A, Nechyporuk-Zloy V, Fabian A, Stock C. Cells move when ions and water flow. Pflugers Arch 2007;453:421-432. (Pubitemid 46011163)
35. Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 2006;98:818-827.
36. Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H. Involvement of the bone morphogenetic protein system in endothelin- and aldosteroneinduced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. Hypertens Res 2010;33:435-445.
37. Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J. Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol 2007;292:L1473-L1479. (Pubitemid 47077364)
38. Chen S, Guttridge DC, Tang E, Shi S, Guan KL, Wang CY. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor bindependent bone morphogenetic protein/Smad signaling. J Biol Chem 2001;276:39259-39263.
39. Shimizu T, Numata T, Okada Y. A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proc Natl Acad Sci USA 2004;101:6770-6773. (Pubitemid 38586049)