Increased Risk of Falls and Increased Bone Resorption in Elderly Men with Partial Androgen Deficiency: The MINOS Study

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5240-5247

  Szulc, P ^a   Claustrat, B ^b   Marchand, F ^c   Delmas, P D ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b HÔPITAL NEUROLOGIQUE   (France)

^c Soc de Secours Miniere de Bourgogne ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; BIOLOGICAL MARKER; ESTRADIOL; FAT; TESTOSTERONE;

ADULT; AGED; AGING; ANDROGEN DEFICIENCY; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; BONE DENSITY; BONE MINERAL; CALCULATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; ELDERLY CARE; ESTRADIOL BLOOD LEVEL; FALLING; HEALTH STATUS; HORMONE ACTION; HORMONE DEFICIENCY; HUMAN; HYPOGONADISM; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; MUSCLE MASS; MUSCLE STRENGTH; OBESITY; OSSIFICATION; OSTEOLYSIS; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SKELETAL MUSCLE; SMOKING HABIT; STANDING; TESTOSTERONE BLOOD LEVEL; WALKING;

ACCIDENTAL FALLS; ACID-BASE EQUILIBRIUM; ADULT; AGED; BIOLOGICAL MARKERS; BODY COMPOSITION; BONE DENSITY; BONE RESORPTION; FRACTURES, BONE; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; MUSCLE CONTRACTION; OSTEOPOROSIS; PROSPECTIVE STUDIES; REFERENCE VALUES; RISK FACTORS; TESTOSTERONE;

EID: 0344874544     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030200     Document Type: Article

References (63)

1. Vermeulen A 2001 Androgen replacement therapy in the aging male: a critical evaluation. J Clin Endocrinol Metab 86:2380-2390
2. Morales A, Heaton JPW, Carson III CC 2000 Andropause: a misnomer for a true clinical entity. J Urol 163:705-712
3. van den Beld AW, de Jong FH, Grobbee DE, Pols HAP, Lamberts SWJ 2000 Measures of bioavailable tesosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
4. Goemaere S, van Pottelbergh I, Zmierczak H, Toye K, Daems M, Demuynck R, Myny H, de Bacquer D, Kaufman JM 2001 Inverse association between bone turnover rate and bone mineral density in community-dwelling men >70 years of age: no major role of sex steroid status. Bone 29:286-291
5. Greendale GA, Edelstein S, Barrett-Connor E 1997 Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J Bone Miner Res 12:1833-1843
6. Amin S, Zhang Y, Sawin CT, Evans SR, Hannan MT, Kiel DP, Wilson PWF, Felson DT 2000 Association of hypogonadism and estradiol levels woth bone mineral density in elderly men from the Framingham study. Ann Intern Med 133:951-963
7. Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD 2001 Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS study. J Clin Endocrinol Metab 86:192-199
8. Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274
9. Short KR, Nair KS 1999 Mechanisms of sarcopenia of aging. J Endocrinol Invest 22:95-105
10. Balagopal P, Rooyackers OE, Adey DB, Ades PA, Nair KS 1997 Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol 273:E790-E800
11. Nevitt MC, Cummings SR, Kidd S, Black D 1989 Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA 261:2663-2668
12. Graafmans WC, Ooms ME, Hofstee HMA, Bezemer PD, Bouter LM, Lips P 1996 Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 143:1129-1136
13. Bhasin S, Woodhouse L, Storer TW 2001 Proof of the effect of testosterone on skeletal muscle. J Endocrinol 170:27-38
14. Jackson JA, Riggs MW, Spiekerman AM 1992 Testosterone deficiency as a risk factor for hip fractures in men: a case-control study. Am J Med Sci 304:4-8
15. Stanley HL, Schmitt BP, Poses RM, Deiss WP 1991 Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 39:766-771
16. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
17. Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, Shikuma C, Nelson JC, Landgren BM, Mazer NA, Bhasin S 1998 The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 83:1312-1318
18. Hammond GL, Nisker JA, Jones LA, Siiteri PK 1980 Estimation of the percentage of free steroid in undiluted serum by centrifugal ultrafiltration-dialysis. J Biol Chem 255:5023-5026
19. Rosner W 2001 An extraordinarily inaccurate assay for free testosterone is still with us. J Clin Endocrinol Metab 86:2903
20. Rosner W 1997 Errors in the measurement of plasma free testosterone. J Clin Endocrinol Metab 82:2014-2015
21. Vermeulen A, Stoïca T, Verdonck L 1971 The apparent free testosterone concentration, an index of androgenicity. J Clin Endocrinol 33:759-767
22. Szulc P, Marchand F, Dubeouf F, Delmas PD 2000 Cross-sectional assessment of age-related bone loss in men: the MINOS study. Bone 26:123-129
23. Tinetti ME, Ginter SF 1988 Identifying mobility dysfunctions in elderly patients. Standard neuromuscular examination or direct assessment? JAMA 259: 1190-1193
24. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB 1994 A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol Med Sci Biol Sci 49:M85-M94
25. Ferrer M, Lamarca R, Orfila F, Alonso J 1999 Comparison of performance-based and self-rated functional capacity in Spanish elderly. Am J Epidemiol 149:228-235
26. Guralnik JM, Ferruci L, Simonsick EM, Salive ME, Wallace RB 1995 Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332:556-561
27. Garnero P, Grimaux M, Demiaux B, Preaudat C, Seguin P, Delmas PD 1992 Measurement of serum osteocalcin with human-specific two-site immunoradiometric assay. J Bone Miner Res 7:1389-1398
28. Gomez Jr B, Ardakani S, Ju J, Jenkins D, Cerelli MJ, Daniloff GY, Kung VT 1995 Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum. Clin Chem 41:1560-1566
29. Melkko J, Kauppila S, Niemi S, Risteli L, Haukipuro K, Jukkola A, Risteli J 1996 Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem 42:947-954
30. Garnero P, Gineyts E, Riou JP, Delmas PD 1994 Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab 79:780-785
31. Pedersen BJ, Ravn P, Bonde M 1998 Type I collagen C-telopeptide degradation products as bone resorption markers. J Clin Ligand Assay 21:118-127
32. Fledelius C, Johnsen AH, Cloos PAC, Bonde M, Qvist P 1997 Characterization of urinary degradation products derived from type I collagen. Identification of a β-isomerizes Asp-Gly sequence within the C-terminal telopeptide (α1) region. J Biol Chem 272:9755-9763
33. Christgau S, Rosenquist C, Alexandersen P, Bjarnason NH, Ravn P, Fledelius C, Herling C, Qvist P, Christiansen C 1998 Clinical evaluation of the serum CrossLaps one step ELISA, a new assay measuring the serum concentration of bone-derived degradation products of type I collagen C-telopeptides. Clin Chem 44:2290-2300
34. Rosenquist C, Fledelius C, Christgau S, Pedersen BJ, Bonde M, Qvist P, Christiansen C 1998 Serum CrossLaps one step ELISA. First application of monoclonal antobodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Clin Chem 44:2281-2289
35. Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ 1994 Direct, enzyme-linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 9:1643-1649
36. Heymsfield SB, Smith R, Aulet M, Bensen B, Lichtman S, Wang J, Pierson Jr RN 1990 Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 52:214-218
37. Wang ZM, Visser M, Ma R, Baumgartner RN, Kotler D, Gallagher D, Heymsfield SB 1996 Skeletal muscle mass: evaluation of neutron activation and dual-energy x-ray absorptiometry methods. J Appl Physiol 80:824-831
38. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Linderman RD 1998 Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147:755-763
39. Bremond AG, Claustrat B, Rudigoz RC, Seffert P, Corniau J 1982 Estradiol, androstenedione, and dehydroepiandrosterone sulfate in the ovarian and peripheral blood of postmenopausal patients with and without endometrial cancer. Gynecol Oncol 14:119-124
40. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ 1997 Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439-443
41. Feldman HA, Lonhcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB 2002 Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87:589-598
42. Morales A, Lunenfeld B 2001 Androgen replacement therapy in aging men with secondary hypogonadism. Aging Male 4:151-162
43. Khosla S, Melton III LJ, Riggs BL 2002 Estrogen and the male skeleton. J Clin Endocrinol Metab 87:1443-1450
44. Khosla S, Melton III LJ, Atkinson EJ, O'Fallon WM 2001 Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86:3555-3561
45. Stoch SA, Parker RA, Chen L, Bubley G, Ko YJ, Vincelette A, Greenspan SL 2001 Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists. J Clin Endocrinol Metab 86:2787-2791
46. Smith MR, McGovern FJ, Zietman AL, Fallon MA, Hayden DL, Schoenfeld DA, Kantoff PW, Finkelstein JS, Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 345:948-955
47. Daniell HW 1997 Osteoporosis after orchiectomy for prostate cancer. J Urol 157:439-444
48. Diamond T, Campbell J, Bryant C, Lynch W 1998 The effect of combined androgen blockade on bone turnover and bone mineral densities in men treated for prostate carcinoma. Cancer 83:1561-1566
49. Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A, Veldhuis J, Dudley RE, Berman N, Davidson T, Barstow TJ, Sinow R, Alexander G, Swerdloff RS 1996 Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men: a clinical research center study. J Clin Endocrinol Metab 81:3654-3662
50. Szulc P, Garnero P, Munoz F, Marchand F, Delmas PD 2001 Cross-sectional evaluation of bone metabolism in men. J Bone Miner Res 16:1642-1650
51. Reed RL, Pearlmutter L, Yochum K, Meredith KE, Mooradian AD 1991 The relationship between muscle mass and muscle strength in the elderly. J Am Geriatr Soc 39:555-561
52. Visser M, Deeg DJ, Lips P, Harris TB, Bouter LM 2000 Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 48:381-386
53. Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS 2001 Sarcopenia. J Lab Clin Med 137:231-243
54. Frontera WR, Suh D, Krivickas LS, Hughes VA, Goldstein R, Roubenoff R 2000 Skeletal muscle fiber quality in older men and women. Am J Physiol 279:C611-C618
55. Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ 1999 Predictors of skeletal muscle mass in elderly men and women. Mech Aging Dev 107:123-136
56. Smith MR, Finkelstein JS, McGovern FJ, Zietman AL, Fallon MA, Schoenfeld DA, Kantoff PW 2002 Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 87:599-603
57. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD, Urban RJ 1998 Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength and adiposity. J Clin Endocrinol Metab 83:1886-1892
58. Morley JE, Kaiser F, Raum WJ, Perry III HM, Flood JF, Jensen J, Silver AJ, Roberts E 1997 Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulphate, and the ration of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA 94:7537-7542
59. Brodsky IG, Balagopal P, Nair KS 1996 Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 81:3469-3475
60. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto AM, Weber T, Berman N 2000 Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol Metab 86:2839-2853
61. Morley JE, Perry III HM, Kaiser FE, Kraenzle D, Jensen J, Houston K, Mattammal M, Perry Jr HM 1993 Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 41:149-152
62. Kenny AM, Prestwood KM, Gruman CA, Marcello KM, Raisz LG 2001 Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol Med Sci Biol Sci 56A:M266-M272
63. Sih R, Morley JE, Kaiser FE, Perry III HM, Patrick P, Ross C 1997 Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 82:1661-1667