Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69 A, Issue 3, 2014, Pages 274-281

  Lee Hong, S ^a   Longo, Kenneth A ^b   Gosney, Elahu ^c   Kopchick, John J ^a,c  

^a OHIO UNIVERSITY   (United States)

^b Proteostasis Therapeutics   (United States)

^c OHIO UNIVERSITY   (United States)

Author keywords

Animal model; Growth hormone; Longevity; Metabolism

Indexed keywords

GROWTH HORMONE RECEPTOR;

ALGORITHM; ANIMAL; ANIMAL MODEL; ARTICLE; BODY MASS; BREATHING; COMPARATIVE STUDY; ENERGY METABOLISM; ENTROPY; FEMALE; GENE DELETION; GENETICS; GROWTH HORMONE.; KNOCKOUT MOUSE; LOCOMOTION; LONGEVITY; METABOLISM; MOUSE; OXYGEN CONSUMPTION; PHYSIOLOGY;

ANIMAL MODEL; GROWTH HORMONE.; LONGEVITY; METABOLISM;

ALGORITHMS; ANIMALS; BODY MASS INDEX; ENERGY METABOLISM; ENTROPY; FEMALE; GENE DELETION; LOCOMOTION; LONGEVITY; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; OXYGEN CONSUMPTION; RECEPTORS, SOMATOTROPIN; RESPIRATION;

EID: 84896747719     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt090     Document Type: Article

References (29)

1. Lipsitz LA, Goldberger AL. Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA. 1992;267:1806-1809.
2. Morrison S, Newell KM. Aging, neuromuscular decline, and the change in physiological and behavioral complexity of upper-limb movement dynamics. J Aging Res. 2012;2012:891218.
3. Goldberger AL, Peng CK, Lipsitz LA. What is physiologic complexity and how does it change with aging and disease? Neurobiol Aging. 2002;23:23-26.
4. Lipsitz LA. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci. 2002;57:B115-B125.
5. Vaillancourt DE, Newell KM. Changing complexity in human behavior and physiology through aging and disease. Neurobiol Aging. 2002;23:1-11.
6. Hong SL. The dynamics of structural and functional complexity across the lifespan. Nonlinear Dynamics Psychol Life Sci. 2007;11:219-234.
7. Zhou Y, Xu BC, Maheshwari HG, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A. 1997;94:13215-13220.
8. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 2000;141:2608-2613.
9. List EO, Sackmann-Sala L, Berryman DE, et al. Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev. 2011;32:356-386.
10. Laron Z. Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech Ageing Dev. 2005;126:305-307.
11. Bartke A, Chandrashekar V, Dominici F, et al. Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights. Biogerontology. 2003;4:1-8.
12. Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ. Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res. 2004;14:309-318.
13. Berryman DE, List EO, Kohn DT, Coschigano KT, Seeley RJ, Kopchick JJ. Effect of growth hormone on susceptibility to dietinduced obesity. Endocrinology. 2006;147:2801-2808.
14. Berryman DE, List EO, Palmer AJ, et al. Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci. 2010;65:31-40.
15. Brown-Borg HM, Bartke A. GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci. 2012;67:652-660.
16. Bellush LL, Doublier S, Holland AN, Striker LJ, Striker GE, Kopchick JJ. Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice. Endocrinology. 2000;141:163-168.
17. Galgani JE, Moro C, Ravussin E. Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab. 2008;295:E1009-E1017.
18. West BJ. Where Medicine Went Wrong: Rediscovering the Path to Complexity. Hackensack, NJ: World Scientific; 2006.
19. Longo KA, Berryman DE, Kelder B, et al. Daily energy balance in growth hormone receptor/binding protein (GHR-/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Horm IGF Res. 2010;20:73-79.
20. Pincus SM, Singer BH. Randomness and degrees of irregularity. Proc Natl Acad Sci U S A. 1996;93:2083-2088.
21. Pincus SM. Approximate entropy as a measure of system complexity. Proc Natl Acad Sci U S A. 1991;88:2297-2301.
22. Hong SL, Manor B, Li L. Stance and sensory feedback influence on postural dynamics. Neurosci Lett. 2007;423:104-108.
23. Churruca J, Vigil L, Luna E, Ruiz-Galiana J, Varela M. The route to diabetes: loss of complexity in the glycemic profile from health through the metabolic syndrome to type 2 diabetes. Diabetes Metab Syndr Obes. 2008;1:3-11.
24. Bergouignan A, Rudwill F, Simon C, Blanc S. Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies. J Appl Physiol. 2011;111:1201-1210.
25. Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr. 2003;78:361-369.
26. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A. 2006;103:7901-7905.
27. Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev. 1998;19:608-624.
28. Panici JA, Wang F, Bonkowski MS, et al. Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans? J Gerontol A Biol Sci Med Sci. 2009;64:1126-1133.
29. Kalyani RR, Varadhan R, Weiss CO, Fried LP, Cappola AR. Frailty status and altered glucose-insulin dynamics. J Gerontol A Biol Sci Med Sci. 2012;67:1300-1306.