Frailty status and altered glucose-insulin dynamics

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67, Issue 12, 2012, Pages 1300-1306

  Kalyani, Rita Rastogi ^a   Varadhan, Ravi ^a   Weiss, Carlos O ^a   Fried, Linda P ^b   Cappola, Anne R ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dynamics; Elderly; Frailty; Glucose; Insulin

Indexed keywords

INSULIN;

AGED; ARTICLE; BLOOD; FEMALE; FRAIL ELDERLY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEALTH STATUS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL;

AGED, 80 AND OVER; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; FRAIL ELDERLY; GLUCOSE TOLERANCE TEST; HEALTH STATUS; HUMANS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; PREDIABETIC STATE;

EID: 84867528309     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr141     Document Type: Article

References (26)

1. Davidson MB. The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism. 1979;28:688-705. (Pubitemid 9187453)
2. Metter EJ, Windham BG, Maggio M, et al. Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. Diabetes Care. 2008;31:1026-1030.
3. Cowie CC, Rust KF, Ford ES, et al. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care. 2009;32:287-294.
4. American Diabetes Association. Standards of medical care in diabetes- 2011. Diabetes Care. 2011;34:S11-S61.
5. Paolisso G, Gambardella A, Ammendola S, et al. Glucose tolerance and insulin action in healthy centenarians. Am J Physiol. 1996;270: E890-E894.
6. Fried LP, Tangen CM, Walston J, et al. Cardiovascular Health Study. Frailty in older adults: evidence for a phenotype. J Gerontol A Med Sci. 2001;56:M146-M156. (Pubitemid 32187141)
7. Bandeen-Roche K, Xue QL, Ferrucci L, et al. Phenotype of frailty: characterization in the women ' s health and aging studies. J Gerontol A Biol Sci Med Sci. 2006;61:262-266.
8. Walston J, McBurnie MA, Newman A, et al. Cardiovascular Health Study. Frailty and activation of the infl ammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162:2333-2341. (Pubitemid 35332516)
9. Blaum CS, Xue QL, Tian J, Semba RD, Fried LP, Walston J. Is hyper-glycemia associated with frailty status in older women? J Am Geriatr Soc. 2009;57:840-847.
10. Barzilay JI, Blaum C, Moore T, et al. Insulin resistance and infl amma-tion as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med. 2007;167:635-641. (Pubitemid 46598454)
11. Goulet ED, Hassaine A, Dionne IJ, et al. Frailty in the elderly is associated with insulin resistance of glucose metabolism in the posta-bsorptive state only in the presence of increased abdominal fat. Exp Gerontol. 2009;44:740-744.
12. Fried LP, Xue QL, Cappola AR, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009;64:1049-1057.
13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. (Pubitemid 15018832)
14. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care. 1999;22:1462-1470.
15. Rousseeuw PJ, Leroy AM. Robust Regression and Outlier Detection; NewYork, NY: John Wiley & Sons; 1987.
16. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R. Baltimore Longitudinal Study of Aging. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes. 2003;52:1475-1484. (Pubitemid 36666204)
17. Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AW, Andres R. Age as an independent determinant of glucose tolerance. Diabetes. 1991;40:44-51.
18. DeFronzo RA. Glucose intolerance and aging. Diabetes Care. 1981;4:493-501.
19. Scheen AJ. Diabetes mellitus in the elderly: insulin resistance and/or impaired secretion? Diabetes Metab. 2005;31:5S27-5S34. (Pubitemid 43106441)
20. Sorkin JD, Muller DC, Fleg JL, Andres R. The relation of fasting and 2-h postchallenge plasma glucose concentrations to mortality: data from the Baltimore Longitudinal Study of Aging with a critical review of the literature. Diabetes Care. 2005;28:2626-2632. (Pubitemid 43951150)
21. Smith NL, Barzilay JI, Shaffer D, et al. Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the Cardiovascular Health Study. Arch Intern Med. 2002;162:209-216. (Pubitemid 34098191)
22. Lee CC, Adler AI, Sandhu MS, et al. Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis. Diabeto-logia. 2009;52:1040-1047.
23. Rasmussen BB, Fujita S, Wolfe RR, et al. Insulin resistance of muscle protein anabolism in aging. FASEB J. 2006;20:768-769. (Pubitemid 46671209)
24. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006;147:4160-4168. (Pubitemid 44268367)
25. Barbieri M, Ferrucci L, Ragno E, et al. Chronic infl ammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab. 2003;284:E481-E487. (Pubitemid 36237535)
26. Serra-Prat M, Palomera E, Clave P, Puig-Domingo M. Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test. Am J Clin Nutr. 2009;89:1410-1417.