Neuroprotective effects of ginsenoside Rg1 against oxygen-glucose deprivation in cultured hippocampal neurons

Journal of the Chinese Medical Association

Volumn 77, Issue 3, 2014, Pages 142-149

  He, Qing ^a   Sun, Jianguo ^b   Wang, Qin ^b   Wang, Wei ^b   He, Bin ^b  

^a First Hospital of Xu Zhou   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Calcium overload; Cerebral ischemia; Ginsenoside Rg1; Hippocampal neurons; Nitric oxide synthase

Indexed keywords

CALCIUM; GINSENOSIDE RG 1; GLUCOSE; NEURONAL NITRIC OXIDE SYNTHASE; OXYGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HIPPOCAMPAL NEURONAL CULTURE; NEUROPROTECTION; NONHUMAN; RAT; REOXYGENATION; REPERFUSION INJURY;

CALCIUM OVERLOAD; CEREBRAL ISCHEMIA; GINSENOSIDE RG1; HIPPOCAMPAL NEURONS; NITRIC OXIDE SYNTHASE;

ANIMALS; CALCIUM; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; GINSENOSIDES; GLUCOSE; HIPPOCAMPUS; NEURONS; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84896733877     PISSN: 17264901     EISSN: 17287731     Source Type: Journal    
DOI: 10.1016/j.jcma.2014.01.001     Document Type: Article

References (33)

1. Minnerup J., Sutherland B.A., Buchan A.M., Kleinschnitz C. Neuroprotection for stroke: current status and future perspectives. Int J Mol Sci 2012, 13:11753-11772.
2. Qi L.W., Wang C.Z., Yuan C.S. Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep 2011, 28:467-495.
3. Attele A.S., Wu J.A., Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999, 58:1685-1693.
4. Qi L.W., Wang C.Z., Yuan C.S. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 2011, 72:689-699.
5. Liu Z.J., Zhao M., Zhang Y., Xue J.F., Chen N.H. Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway. Brain Res 2010, 1333:1-8.
6. Liao B., Newmark H., Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons invitro. Exp Neurol 2002, 173:224-234.
7. Leung K.W., Yung K.K., Mak N.K., Chan Y.S., Fan T.P., Wong R.N. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 2007, 52:827-835.
8. Liu M., Zhang J.T. Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons. Acta Pharm Sin 1999, 30:674-678.
9. Li J.Q., Zhang X.G., Zhang J.T. Study on the anti-apoptotic mechanism of ginsenoside Rg1 in cultured cortical neurons. Acta Pharm Sin 1997, 32:406-410. [Article in Chinese].
10. Radad K., Gille G., Moldzio R., Saito H., Rausch W.D. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 2004, 1021:41-53.
11. Chen X.C., Fang F., Zhu Y.G., Chen L.M., Zhou Y.C., Chen Y. Protective effect of ginsenoside Rg1 on MPP+-induced apoptosis in SHSY5Y cells. J Neural Transm 2003, 110:835-845.
12. Orrenius S., Zhivotovsky B., Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003, 4:552-565.
13. 2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci 2005, 360:2255-2258.
14. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A 1991, 88:6368-6371.
15. Buisson A., Plotkine M., Boulu R.G. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. Br J Pharmacol 1992, 106:766-767.
16. Yun H.Y., Dawson V.L., Dawson T.M. Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide. Diabetes Res Clin Pract 1999, 45:113-115.
17. Eliasson M.J., Huang Z., Ferrante R.J., Sasamata M., Molliver M.E., Snyder S.H., et al. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J Neurosci 1999, 19:5910-5918.
18. Kira M., Tanaka J., Sobue K. Caldesmon and low Mr isoform of tropomyosin are localized in neuronal growth cones. J Neurosci Res 1995, 40:294-305.
19. Schäbitz W.R., Kollmar R., Schwainger M., Juettler E., Bardutzky J., Schölzke M.N., et al. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 2003, 34:745-751.
20. + influx and catecholamine secretion in bovine adrenal chromaffin cells. J Pharmacol Exp Ther 1995, 273:629-636.
21. Radad K., Gille G., Liu L., Rausch W.D. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006, 100:175-186.
22. Rausch W.D., Liu S., Gille G., Radad K. Neuroprotective effects of ginsenosides. Acta Neurobiol Exp 2006, 66:369-375.
23. Chu G.X., Chen X. Anti-lipid peroxidation and protection of ginsenosides against cerebral ischemia-reperfusion injuries in rats. Zhongguo Yao Li Xue Bao 1990, 11:119-123.
24. Salim K.N., McEwen B.S., Chao H.M. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. Mol Brain Res 1997, 47:177-182.
25. Kim Y.C., Kim S.R., Markelonis G.J., Oh T.H. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 1998, 53:426-432.
26. Wang J., Xu H.M., Yang H.D., Du X.X., Jiang H., Xie J.X. Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochem Int 2009, 54:43-48.
27. Carafoli E., Santella L., Branca D., Brini M. Generation, control, and processing of cellular calcium signals. Crit Rev Biochem Mol Biol 2001, 36:107-260.
28. Chen Z., Lu T., Yue X., Wei N., Jiang Y., Chen M., et al. Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy. Neurosci Lett 2010, 482:264-268.
29. Moncada S., Higgs A., Furchgott R. International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 1997, 49:137-142.
30. Lipton S.A., Choi Y.B., Pan Z.H., Lei S.Z., Chen H.S., Sucher N.J., et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993, 364:626-632.
31. Brown G.C. Nitric oxide and neuronal death. Nitric Oxide 2010, 23:153-165.
32. Förstermann U., Sessa W.C. Nitric oxide synthases: regulation and function. Eur Heart J 2012, 33:829-837.
33. 2+ channels. Eur J Pharmacol 2008, 586:90-99.