PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells

Digestive Diseases and Sciences

Volumn 59, Issue 3, 2014, Pages 598-606

  Li, Yanwen ^a,b   Li, Yuehui ^a   Liu, Yanhong ^a   Xie, Pingli ^a   Li, Feng ^a   Li, Guancheng ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Colorectal cancer; Invasion; MicroRNA 7; Paired box 6 (PAX6); Proliferation

Indexed keywords

GELATINASE A; GELATINASE B; MICRORNA; MICRORNA 7; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL STRAIN CACO 2; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUCIFERASE ASSAY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; BLOTTING, WESTERN; CACO-2 CELLS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EYE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICRORNAS; NEOPLASM INVASIVENESS; PAIRED BOX TRANSCRIPTION FACTORS; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84896732092     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2929-x     Document Type: Article

References (22)

1. Walther C, Guenet JL, Simon D, et al. Pax: A murine multigene family of paired box-containing genes.Genomics. 1991;11:424-434.
2. Georgala PA, Carr CB, Price DJ. The role of Pax6 in forebrain development. Dev Neurobiol. 2011;71:690-709.
3. Eriksson BJ, Samadi L, Schmid A. The expression pattern of the genes engrailed, pax6, otd and six3 with special respect to head and eye development in Euperipatoides kanangrensis Reid 1996 (Onychophora: Peripatopsidae). Dev Genes Evol. 2013;223: 237-246.
4. Hart AW, Mella S, Mendrychowski J, van Heyningen V, Kleinjan DA. The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas. PLoS One. 2013;8:e54173.
5. Elso C, Lu X, Weisner PA, et al. A reciprocal translocation dissects roles of Pax6 alternative promoters and upstream regulatory elements in the development of pancreas, brain, and eye. Genesis. 2013;51:630-646.
6. Liu RZ, Monckton EA, Godbout R. Regulation of the FABP7 gene by PAX6 in malignant glioma cells. Biochem Biophys Res Commun. 2012;422:482-487.
7. Wang J, Wang X, Wu G, Hou D, Hu Q. MiR-365b-3p, downregulated in retinoblastoma, regulates cell cycle progression and apoptosis of human retinoblastoma cells by targeting Pax6. FEBS Lett. 2013;587:1779-1786.
8. Zong X, Yang H, Yu Y, et al. Possible role of Pax-6 in promoting breast cancer cell proliferation and tumorigenesis. BMB Rep. 2011;44:595-600.
9. Shyr CR, Tsai MY, Yeh S, et al. Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. Prostate. 2010;70:190-199.
10. Hellwinkel OJ, Kedia M, Isbarn H, Budaus L, Friedrich MG. Methylation of the TPEF-and PAX6-promoters is increased in early bladder cancer and in normal mucosa adjacent to pTa tumours. BJU Int. 2008;101:753-757.
11. Salem CE, Markl ID, Bender CM, Gonzales FA, Jones PA, Liang G. PAX6 methylation and ectopic expression in human tumor cells. Int J Cancer. 2000;87:179-185.
12. Ambros V. The functions of animal microRNAs. Nature. 2004;431:350-355.
13. Shen J, Stass SA, Jiang F. MicroRNAs as potential biomarkers in human solid tumors. Cancer Lett. 2013;329:125-136.
14. Nana-Sinkam SP, Croce CM. Clinical applications for microRNAs in cancer. Clin Pharmacol Ther. 2013;93:98-104.
15. Zhang N, Li X, Wu CW et al. microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. Oncogene. 2013;32:5078-5088.
16. Boncheva V, Bonney SA, Brooks SE, et al. New targets for the immunotherapy of colon cancer-does reactive disease hold the answer? Cancer Gene Ther. 2013;20:157-168.
17. Simpson TI, Price DJ. Pax6; a pleiotropic player in development. Bioessays. 2002;24:1041-1051.
18. Li L, Li B, Zhang H, et al. Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells. Invest Ophthalmol Vis Sci. 2011;52:8393-8400.
19. Wang S, J Xiang, Li Z, et al. A plasma microRNA panel for early detection of colorectal cancer. Int J Cancer. 2013.doi:10.1002/ijc. 28136
20. Kredo-Russo S, Mandelbaum AD, Ness A, et al. Pancreas-enriched miRNA refines endocrine cell differentiation. Development. 2012;139:3021-3031.
21. Chetram MA, Hinton CV. PTEN regulation of ERK1/2 signaling in cancer. J Recept Signal Transduct Res. 2012;32:190-195.
22. Artacho-Cordon F, Rios-Arrabal S, Lara PC, Artacho-Cordon A, Calvente I, Nunez MI. Matrix metalloproteinases: Potential therapy to prevent the development of second malignancies after breast radiotherapy. Surg Oncol. 2012;21:e143-e151.