-
1
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275, 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
2
-
-
78751493647
-
Loss of PTEN permits CXCR4-Nediated tumorigenesis through ERK1/2 in prostate cancer cells
-
Chetram MA, Odero-Narah V, Hinton CV. Loss of PTEN permits CXCR4-Nediated tumorigenesis through ERK1/2 in prostate cancer cells. Mol Cancer Res 2011, 9, 90-102.
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 90-102
-
-
Chetram, M.A.1
Odero-Narah, V.2
Hinton, C.V.3
-
3
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004, 22, 2954-2963.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
4
-
-
33644860571
-
Tumor suppressor genes in breast cancer: The gatekeepers and the caretakers
-
Oliveira AM, Ross JS, Fletcher JA. Tumor suppressor genes in breast cancer: The gatekeepers and the caretakers. Am J Clin Pathol 2005, 124 Suppl, S16-S28.
-
(2005)
Am. J. Clin. Pathol.
, vol.124
, Issue.SUPPL.
-
-
Oliveira, A.M.1
Ross, J.S.2
Fletcher, J.A.3
-
5
-
-
0032577699
-
The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3 4,5-Trisphosphate
-
Maehama T, Dixon JE. The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-Trisphosphate. J Biol Chem 1998, 273, 13375-13378.
-
(1998)
J. Biol. Chem.
, Issue.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
6
-
-
0038648321
-
Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium
-
Wu R, Sun S, Steinberg BM. Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium. Mol Med 2003, 9, 77-84.
-
(2003)
Mol. Med.
, vol.9
, pp. 77-84
-
-
Wu, R.1
Sun, S.2
Steinberg, B.M.3
-
7
-
-
34249815200
-
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN
-
Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 2007, 11, 555-569.
-
(2007)
Cancer Cell
, vol.11
, pp. 555-569
-
-
Vivanco, I.1
Palaskas, N.2
Tran, C.3
Finn, S.P.4
Getz, G.5
Kennedy, N.J.6
Jiao, J.7
Rose, J.8
Xie, W.9
Loda, M.10
Golub, T.11
Mellinghoff, I.K.12
Davis, R.J.13
Wu, H.14
Sawyers, C.L.15
-
8
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998, 280, 1614-1617.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
9
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275, 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
10
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997, 15, 356-362.
-
(1997)
Nat. Genet.
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.14
Tavtigian, S.V.15
-
11
-
-
0030140025
-
Localization of the gene for Cowden disease to chromosome 10q22-23
-
Nelen MR, Padberg GW, Peeters EA, Lin AY, Van Den Helm B, Frants RR, Coulon V, Goldstein AM, van Reen MM, Easton DF, Eeles RA, Hodgsen S, Mulvihill JJ, Murday VA, Tucker MA, Mariman EC, Starink TM, Ponder BA, Ropers HH, Kremer H, Longy M, Eng C. Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 1996, 13, 114-116.
-
(1996)
Nat. Genet.
, vol.13
, pp. 114-116
-
-
Nelen, M.R.1
Padberg, G.W.2
Peeters, E.A.3
Lin, A.Y.4
Van Den Helm, B.5
Frants, R.R.6
Coulon, V.7
Goldstein, A.M.8
Van Reen, M.M.9
Easton, D.F.10
Eeles, R.A.11
Hodgsen, S.12
Mulvihill, J.J.13
Murday, V.A.14
Tucker, M.A.15
Mariman, E.C.16
Starink, T.M.17
Ponder, B.A.18
Ropers, H.H.19
Kremer, H.20
Longy, M.21
Eng, C.22
more..
-
12
-
-
49149086504
-
PTEN: A default gate-keeping tumor suppressor with a versatile tail
-
Wang X, Jiang X. PTEN: A default gate-keeping tumor suppressor with a versatile tail. Cell Res 2008, 18, 807-816.
-
(2008)
Cell Res.
, vol.18
, pp. 807-816
-
-
Wang, X.1
Jiang, X.2
-
13
-
-
0030837555
-
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-Specificity phosphatase
-
Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-Specificity phosphatase. Proc Natl Acad Sci USA 1997, 94, 9052-9057.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9052-9057
-
-
Myers, M.P.1
Stolarov, J.P.2
Eng, C.3
Li, J.4
Wang, S.I.5
Wigler, M.H.6
Parsons, R.7
Tonks, N.K.8
-
14
-
-
80055008724
-
PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling
-
Deevi R, Fatehullah A, Jagan I, Nagaraju M, Bingham V, Campbell FC. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. Br J Cancer 2011, 105, 1313-1321.
-
(2011)
Br. J. Cancer
, vol.105
, pp. 1313-1321
-
-
Deevi, R.1
Fatehullah, A.2
Jagan, I.3
Nagaraju, M.4
Bingham, V.5
Campbell, F.C.6
-
15
-
-
75149135196
-
PTEN loss induces epithelial-Nesenchymal transition in human colon cancer cells
-
Bowen KA, Doan HQ, Zhou BP, Wang Q, Zhou Y, Rychahou PG, Evers BM. PTEN loss induces epithelial-Nesenchymal transition in human colon cancer cells. Anticancer Res 2009, 29, 4439-4449.
-
(2009)
Anticancer Res.
, vol.29
, pp. 4439-4449
-
-
Bowen, K.A.1
Doan, H.Q.2
Zhou, B.P.3
Wang, Q.4
Zhou, Y.5
Rychahou, P.G.6
Evers, B.M.7
-
16
-
-
0035199914
-
The Egr-1 transcription factor directly activates PTEN during irradiation-Induced signalling
-
Virolle T, Adamson ED, Baron V, Birle D, Mercola D, Mustelin T, de Belle I. The Egr-1 transcription factor directly activates PTEN during irradiation-Induced signalling. Nat Cell Biol 2001, 3, 1124-1128.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1124-1128
-
-
Virolle, T.1
Adamson, E.D.2
Baron, V.3
Birle, D.4
Mercola, D.5
Mustelin, T.6
De Belle, I.7
-
17
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW. Regulation of PTEN transcription by p53. Mol Cell 2001, 8, 317-325.
-
(2001)
Mol. Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
Benchimol, S.7
Mak, T.W.8
-
18
-
-
0035873953
-
Tumor suppressor and anti-Inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN
-
Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH. Tumor suppressor and anti-Inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 2001, 11, 764-768.
-
(2001)
Curr. Biol.
, vol.11
, pp. 764-768
-
-
Patel, L.1
Pass, I.2
Coxon, P.3
Downes, C.P.4
Smith, S.A.5
Macphee, C.H.6
-
19
-
-
33644749218
-
PTEN promoter methylation in sporadic thyroid carcinomas
-
Thyroid Neoplasia Study Group
-
Alvarez-Nuñez F, Bussaglia E, Mauricio D, Ybarra J, Vilar M, Lerma E, de Leiva A, Matias-Guiu X; Thyroid Neoplasia Study Group. PTEN promoter methylation in sporadic thyroid carcinomas. Thyroid 2006, 16, 17-23.
-
(2006)
Thyroid
, vol.16
, pp. 17-23
-
-
Alvarez-Nuñez, F.1
Bussaglia, E.2
Mauricio, D.3
Ybarra, J.4
Vilar, M.5
Lerma, E.6
De Leiva, A.7
Matias-Guiu, X.8
-
20
-
-
0036094196
-
Lack of PTEN expression in non-Small cell lung cancer could be related to promoter methylation
-
Soria JC, Lee HY, Lee JI, Wang L, Issa JP, Kemp BL, Liu DD, Kurie JM, Mao L, Khuri FR. Lack of PTEN expression in non-Small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002, 8, 1178-1184.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1178-1184
-
-
Soria, J.C.1
Lee, H.Y.2
Lee, J.I.3
Wang, L.4
Issa, J.P.5
Kemp, B.L.6
Liu, D.D.7
Kurie, J.M.8
Mao, L.9
Khuri, F.R.10
-
21
-
-
4143138570
-
Promoter methylation of the PTEN gene is a common molecular change in breast cancer
-
García JM, Silva J, Peña C, Garcia V, Rodríguez R, Cruz MA, Cantos B, Provencio M, España P, Bonilla F. Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer 2004, 41, 117-124.
-
(2004)
Genes Chromosomes Cancer
, vol.41
, pp. 117-124
-
-
García, J.M.1
Silva, J.2
Peña, C.3
Garcia, V.4
Rodríguez, R.5
Cruz, M.A.6
Cantos, B.7
Provencio, M.8
España, P.9
Bonilla, F.10
-
22
-
-
58149503967
-
PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas
-
Ho CM, Lin MC, Huang SH, Huang CJ, Lai HC, Chien TY, Chang SF. PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. Gynecol Oncol 2009, 112, 307-313.
-
(2009)
Gynecol. Oncol.
, vol.112
, pp. 307-313
-
-
Ho, C.M.1
Lin, M.C.2
Huang, S.H.3
Huang, C.J.4
Lai, H.C.5
Chien, T.Y.6
Chang, S.F.7
-
23
-
-
66149173789
-
The PTEN-Regulating microRNA miR-26a is amplified in high-Grade glioma and facilitates gliomagenesis in vivo
-
Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC. The PTEN-Regulating microRNA miR-26a is amplified in high-Grade glioma and facilitates gliomagenesis in vivo. Genes Dev 2009, 23, 1327-1337.
-
(2009)
Genes Dev.
, Issue.23
, pp. 1327-1337
-
-
Huse, J.T.1
Brennan, C.2
Hambardzumyan, D.3
Wee, B.4
Pena, J.5
Rouhanifard, S.H.6
Sohn-Lee, C.7
Le Sage, C.8
Agami, R.9
Tuschl, T.10
Holland, E.C.11
-
24
-
-
77956061393
-
MicroRNA-21 (miR-21 represses tumor suppressor PTEN and promotes growth and invasion in non-Small cell lung cancer (NSCLC)
-
Zhang JG, Wang JJ, Zhao F, Liu Q, Jiang K, Yang GH. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-Small cell lung cancer (NSCLC). Clin Chim Acta 2010, 411, 846-852.
-
(2010)
Clin. Chim. Acta.
, vol.411
, pp. 846-852
-
-
Zhang, J.G.1
Wang, J.J.2
Zhao, F.3
Liu, Q.4
Jiang, K.5
Yang, G.H.6
-
25
-
-
0035847102
-
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-Nediated degradation
-
Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-Nediated degradation. J Biol Chem 2001, 276, 993-998.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 993-998
-
-
Torres, J.1
Pulido, R.2
-
26
-
-
33845991111
-
NEDD4-1 is a proto-Oncogenic ubiquitin ligase for PTEN
-
Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-Oncogenic ubiquitin ligase for PTEN. Cell 2007, 128, 129-139.
-
(2007)
Cell
, vol.128
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
Alimonti, A.4
Chen, Z.5
Gao, Z.6
Wang, J.7
Erdjument-Bromage, H.8
Tempst, P.9
Cordon-Cardo, C.10
Pandolfi, P.P.11
Jiang, X.12
-
27
-
-
0142137134
-
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
-
Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J 2003, 22, 5501-5510.
-
(2003)
EMBO J.
, vol.22
, pp. 5501-5510
-
-
Leslie, N.R.1
Bennett, D.2
Lindsay, Y.E.3
Stewart, H.4
Gray, A.5
Downes, C.P.6
-
28
-
-
79959745176
-
ROS enhances CXCR4-Nediated functions through inactivation of PTEN in prostate cancer cells
-
Chetram MA, Don-Salu-Hewage AS, Hinton CV. ROS enhances CXCR4-Nediated functions through inactivation of PTEN in prostate cancer cells. Biochem Biophys Res Commun 2011, 410, 195-200.
-
(2011)
Biochem. Biophys Res. Commun.
, vol.410
, pp. 195-200
-
-
Chetram, M.A.1
Don-Salu-Hewage, A.S.2
Hinton, C.V.3
-
29
-
-
0035869212
-
PTEN coordinates G(1) arrest by down-Regulating cyclin D1 via its protein phosphatase activity and up-Regulating p27 via its lipid phosphatase activity in a breast cancer model
-
Weng LP, Brown JL, Eng C. PTEN coordinates G(1) arrest by down-Regulating cyclin D1 via its protein phosphatase activity and up-Regulating p27 via its lipid phosphatase activity in a breast cancer model. Hum Mol Genet 2001, 10, 599-604.
-
(2001)
Hum. Mol. Genet.
, Issue.10
, pp. 599-604
-
-
Weng, L.P.1
Brown, J.L.2
Eng, C.3
-
30
-
-
0033575287
-
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-Dependent phosphatidylinositol 3-kinase/ Akt cell survival pathway
-
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-Dependent phosphatidylinositol 3-kinase/ Akt cell survival pathway. J Biol Chem 1999, 274, 20693-20703.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20693-20703
-
-
Tamura, M.1
Gu, J.2
Danen, E.H.3
Takino, T.4
Miyamoto, S.5
Yamada, K.M.6
-
31
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-Dependent and -Independent mechanisms
-
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-Dependent and -Independent mechanisms. Cancer Cell 2003, 3, 117-130.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
Whale, A.D.7
Martinez-Diaz, H.8
Rozengurt, N.9
Cardiff, R.D.10
Liu, X.11
Wu, H.12
-
32
-
-
77954675751
-
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
-
Roy SK, Srivastava RK, Shankar S. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 2010, 5, 10.
-
(2010)
J. Mol. Signal
, vol.5
, pp. 10
-
-
Roy, S.K.1
Srivastava, R.K.2
Shankar, S.3
-
33
-
-
79952087345
-
EGFR overexpression induces activation of telomerase via PI3K/AKT-Nediated phosphorylation and transcriptional regulation through Hif1-Alpha in a cellular model of oral-Esophageal carcinogenesis
-
Heeg S, Hirt N, Queisser A, Schmieg H, Thaler M, Kunert H, Quante M, Goessel G, von Werder A, Harder J, Beijersbergen R, Blum HE, Nakagawa H, Opitz OG. EGFR overexpression induces activation of telomerase via PI3K/AKT-Nediated phosphorylation and transcriptional regulation through Hif1-Alpha in a cellular model of oral-Esophageal carcinogenesis. Cancer Sci 2011, 102, 351-360.
-
(2011)
Cancer Sci.
, vol.102
, pp. 351-360
-
-
Heeg, S.1
Hirt, N.2
Queisser, A.3
Schmieg, H.4
Thaler, M.5
Kunert, H.6
Quante, M.7
Goessel, G.8
Von Werder, A.9
Harder, J.10
Beijersbergen, R.11
Blum, H.E.12
Nakagawa, H.13
Opitz, O.G.14
-
34
-
-
0037098951
-
PTEN blocks insulin-Nediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway
-
Weng LP, Brown JL, Baker KM, Ostrowski MC, Eng C. PTEN blocks insulin-Nediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway. Hum Mol Genet 2002, 11, 1687-1696.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 1687-1696
-
-
Weng, L.P.1
Brown, J.L.2
Baker, K.M.3
Ostrowski, M.C.4
Eng, C.5
-
35
-
-
30944447568
-
The extracellular signal-Regulated kinase: Multiple substrates regulate diverse cellular functions
-
Yoon S, Seger R. The extracellular signal-Regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors 2006, 24, 21-44.
-
(2006)
Growth Factors
, vol.24
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
36
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch W. Meaningful relationships: The regulation of the Ras/Raf/ MEK/ERK pathway by protein interactions. Biochem J 2000, 351 Pt 2, 289-305.
-
(2000)
Biochem. J.
, vol.351
, Issue.PART 2
, pp. 289-305
-
-
Kolch, W.1
-
37
-
-
79960235543
-
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy
-
Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA. Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. Leukemia 2011, 25, 1080-1094.
-
(2011)
Leukemia
, vol.25
, pp. 1080-1094
-
-
Steelman, L.S.1
Franklin, R.A.2
Abrams, S.L.3
Chappell, W.4
Kempf, C.R.5
Bäsecke, J.6
Stivala, F.7
Donia, M.8
Fagone, P.9
Nicoletti, F.10
Libra, M.11
Ruvolo, P.12
Ruvolo, V.13
Evangelisti, C.14
Martelli, A.M.15
McCubrey, J.A.16
-
38
-
-
0032725554
-
P42/ p44 mitogen-Activated protein kinases phosphorylate hypoxia-Inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, GothiéE, Roux D, Pouysségur J. p42/ p44 mitogen-Activated protein kinases phosphorylate hypoxia-Inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999, 274, 32631-32637.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothié, E.3
Roux, D.4
Pouysségur, J.5
-
39
-
-
0035740560
-
Angiogenesis in prostate cancer: Biology and therapeutic opportunities
-
Nicholson B, Schaefer G, Theodorescu D. Angiogenesis in prostate cancer: Biology and therapeutic opportunities. Cancer Metastasis Rev 2001, 20, 297-319.
-
(2001)
Cancer Metastasis Rev.
, vol.20
, pp. 297-319
-
-
Nicholson, B.1
Schaefer, G.2
Theodorescu, D.3
-
40
-
-
84856295785
-
Regulation of MEK/ERK pathway output by subcellular localization of B-Raf
-
Andreadi C, Noble C, Patel B, Jin H, Aguilar Hernandez MM, Balmanno K, Cook SJ, Pritchard C. Regulation of MEK/ERK pathway output by subcellular localization of B-Raf. Biochem Soc Trans 2012, 40, 67-72.
-
(2012)
Biochem. Soc. Trans.
, vol.40
, pp. 67-72
-
-
Andreadi, C.1
Noble, C.2
Patel, B.3
Jin, H.4
Aguilar Hernandez, M.M.5
Balmanno, K.6
Cook, S.J.7
Pritchard, C.8
-
41
-
-
64849093363
-
PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-Type, hormone refractory prostate cancer cells
-
Bouali S, Chrétien AS, Ramacci C, Rouyer M, Becuwe P, Merlin JL. PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-Type, hormone refractory prostate cancer cells. Oncol Rep 2009, 21, 731-735.
-
(2009)
Oncol. Rep.
, vol.21
, pp. 731-735
-
-
Bouali, S.1
Chrétien, A.S.2
Ramacci, C.3
Rouyer, M.4
Becuwe, P.5
Merlin, J.L.6
-
42
-
-
0028918408
-
Ras-Dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
-
Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT. Ras-Dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 1995, 268, 100-102.
-
(1995)
Science
, vol.268
, pp. 100-102
-
-
Hu, Q.1
Klippel, A.2
Muslin, A.J.3
Fantl, W.J.4
Williams, L.T.5
-
43
-
-
0031037296
-
Linkage of G protein-Coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
-
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G protein-Coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 1997, 275, 394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
44
-
-
33645874515
-
PI3K is required for insulin-Stimulated but not EGF-Stimulated ERK1/2 activation
-
Liu L, Xie Y, Lou L. PI3K is required for insulin-Stimulated but not EGF-Stimulated ERK1/2 activation. Eur J Cell Biol 2006, 85, 367-374.
-
(2006)
Eur. J. Cell Biol.
, vol.85
, pp. 367-374
-
-
Liu, L.1
Xie, Y.2
Lou, L.3
-
45
-
-
0028560447
-
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns- 3,4-P2 and PtdIns-3 4,5-P3
-
Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja S, Parra A, Burns DJ, Ballas LM, Cantley LC. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns- 3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem 1994, 269, 32358-32367.
-
(1994)
J. Biol. Chem.
, Issue.269
, pp. 32358-32367
-
-
Toker, A.1
Meyer, M.2
Reddy, K.K.3
Falck, J.R.4
Aneja, R.5
Aneja, S.6
Parra, A.7
Burns, D.J.8
Ballas, L.M.9
Cantley, L.C.10
-
46
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998, 281, 2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
47
-
-
0039791449
-
Activation of the mitogen-Activated protein kinase/extracellular signal-Regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schönwasser DC, Marais RM, Marshall CJ, Parker PJ. Activation of the mitogen-Activated protein kinase/extracellular signal-Regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol 1998, 18, 790-798.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 790-798
-
-
Schönwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
48
-
-
0037225685
-
Kaposi's sarcoma-Associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-Zeta-NEK-ERK signaling pathway in target cells early during infection: Implications for infectivity
-
Naranatt PP, Akula SM, Zien CA, Krishnan HH, Chandran B. Kaposi's sarcoma-Associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-Zeta-NEK-ERK signaling pathway in target cells early during infection: Implications for infectivity. J Virol 2003, 77, 1524-1539.
-
(2003)
J. Virol.
, vol.77
, pp. 1524-1539
-
-
Naranatt, P.P.1
Akula, S.M.2
Zien, C.A.3
Krishnan, H.H.4
Chandran, B.5
-
49
-
-
41849083428
-
Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells
-
Lee JT, Steelman LS, Chappell WH, McCubrey JA. Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells. Cell Cycle 2008, 7, 631-636.
-
(2008)
Cell Cycle
, vol.7
, pp. 631-636
-
-
Lee, J.T.1
Steelman, L.S.2
Chappell, W.H.3
McCubrey, J.A.4
-
50
-
-
0037163050
-
Regulation of raf-akt cross-talk
-
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M. Regulation of Raf-Akt Cross-Talk. J Biol Chem 2002, 277, 31099-31106.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31099-31106
-
-
Moelling, K.1
Schad, K.2
Bosse, M.3
Zimmermann, S.4
Schweneker, M.5
-
51
-
-
0026678172
-
Association of the Shc and Grb2/Sem5 SH2-Containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
-
Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG. Association of the Shc and Grb2/Sem5 SH2-Containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 1992, 360, 689-692.
-
(1992)
Nature
, vol.360
, pp. 689-692
-
-
Rozakis-Adcock, M.1
McGlade, J.2
Mbamalu, G.3
Pelicci, G.4
Daly, R.5
Li, W.6
Batzer, A.7
Thomas, S.8
Brugge, J.9
Pelicci, P.G.10
-
52
-
-
0033606767
-
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
-
Gu J, Tamura M, Pankov R, Danen EH, Takino T, Matsumoto K, Yamada KM. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol 1999, 146, 389-403.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 389-403
-
-
Gu, J.1
Tamura, M.2
Pankov, R.3
Danen, E.H.4
Takino, T.5
Matsumoto, K.6
Yamada, K.M.7
-
53
-
-
78649804159
-
PTEN augments SPARC suppression of proliferation and inhibits SPARC-Induced migration by suppressing SHC-RAF-ERK and AKT signaling
-
Thomas SL, Alam R, Lemke N, Schultz LR, Gutiérrez JA, Rempel SA. PTEN augments SPARC suppression of proliferation and inhibits SPARC-Induced migration by suppressing SHC-RAF-ERK and AKT signaling. Neuro-Oncology 2010, 12, 941-955.
-
(2010)
Neuro-Oncology
, vol.12
, pp. 941-955
-
-
Thomas, S.L.1
Alam, R.2
Lemke, N.3
Schultz, L.R.4
Gutiérrez, J.A.5
Rempel, S.A.6
-
54
-
-
78649500093
-
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
-
Nogueira C, Kim KH, Sung H, Paraiso KH, Dannenberg JH, Bosenberg M, Chin L, Kim M. Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis. Oncogene 2010, 29, 6222-6232.
-
(2010)
Oncogene
, vol.29
, pp. 6222-6232
-
-
Nogueira, C.1
Kim, K.H.2
Sung, H.3
Paraiso, K.H.4
Dannenberg, J.H.5
Bosenberg, M.6
Chin, L.7
Kim, M.8
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