Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated t cells (NFAT) in response to high glucose

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 4896-4905

  Williams, Clintoria R ^a,b   Gooch, Jennifer L ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; DOWNSTREAM TARGET; HIGH GLUCOSE; ISOFORMS; NADPH OXIDASE; NUCLEAR FACTOR OF ACTIVATED T-CELLS; RENAL CELL; ROS GENERATIONS;

PATHOLOGY;

ENZYME INHIBITION;

ALPHA ISOFORM OF CALCINEURIN; BETA ISOFORM OF CALCINEURIN; CALCINEURIN; GLUCOSE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBUNIT; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

CALCINEURIN; HIGH GLUCOSE; KIDNEY; NADPH OXIDASE; NFAT TRANSCRIPTION FACTOR; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES (ROS); RENAL HYPERTROPHY;

ANIMALS; CALCINEURIN; ENZYME ACTIVATION; FIBROBLASTS; GLUCOSE; HYPERTROPHY; KIDNEY; MEMBRANE GLYCOPROTEINS; MICE; MODELS, BIOLOGICAL; NADPH OXIDASE; NFATC TRANSCRIPTION FACTORS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION, GENETIC;

EID: 84896729661     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.514869     Document Type: Article

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