Loss of the α-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-β

Transplantation

Volumn 83, Issue 4, 2007, Pages 439-447

  Gooch, Jennifer L ^a,b   Roberts, Brian R ^a   Cobbs, Scott L ^a   Tumlin, James A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Cyclosporin; Fibrosis; TGF

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; FIBRONECTIN; ISOENZYME; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; ANTIBODY;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL NUCLEUS; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVITY; FIBROBLAST; FIBROSIS; GENE LOSS; HISTOLOGY; HYALINE DEGENERATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY DYSFUNCTION; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KIDNEY DISEASE; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALS; ANTIBODIES; CALCINEURIN; CELLS, CULTURED; GENE EXPRESSION REGULATION; ISOENZYMES; KIDNEY DISEASES; MICE; MICE, KNOCKOUT; TRANSFORMING GROWTH FACTOR BETA;

EID: 33947491882     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000251423.78124.51     Document Type: Article

References (23)

1. Kahan BD, Keown P, Levy GA, Johnston A. Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther 2002; 24: 330.
2. Busauschina A, Schnuelle P, van der Woude FJ. Cyclosporine nephrotoxicity. Transplant Proc 2004; 36: 229S.
3. Cattaneo D, Perico N, Gaspari F, Remuzzi G. Nephrotoxic aspects of cyclosporine. Transplant Proc 2004; 36: 234S.
4. Rusnak F, Mertz P. Calcineurin: form and function. Physiol Rev 2000; 80: 1483.
5. Lim HW, De Windt LJ, MAnte J, et al. Reversal of cardiac hypertrophy in transgenic disase models by calcineurin inhibition. J Mol Cell Cardiol 2000; 32: 697.
6. Gooch JL, Pergola PE, Guler RL, et al. Differential expression of calcineurin A isoforms in the diabetic kidney. J Am Soc Neph 2004; 15: 1421.
7. Zhang BW, Zimmer G, Chen J, et al. T cell responses in calcineurin A alpha-deficient mice. J Exp Med 1996; 183(2): 413.
8. Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD. Defective T cell development and function in calcineurin Abeta-deficient mice. Proc Nat Acad Sci 2002; 99: 9398.
9. Gooch JL, Toro JJ, Guler RL, Barnes JL. Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathology 2004; 165: 1755.
10. Bueno OF, Wilkins BJ, Tymitz KM, et al. Impaired cardiac hypertrophic response in calcineurin Abeta-deficient mice. Proc Nat Acad Sci 2002; 99: 4586.
11. Gooch JL, Gorin Y, Zhang BX, Abboud HE. Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation. J Biol Chem 2004; 279: 15561.
12. Gooch JL, Barnes JL, Garcia S, Abboud HE. Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation. Am J Physiol Renal Physiol 2003; 284: F144.
13. Fruman DA, Pai S-Y, Klee CN, et al. Measurement of calcineurin phosphatase activity in cell extracts. Meth Enzymol 1996; 9: 146.
14. Gooch JL, Tang Y, Ricono JM, Abboud HE. Insulin-like growth factor-I induces renal cell hypertrophy via a calcineurin-dependent mechanism. J Biol Chem 2001; 276: 42492.
15. Myers BD, Ross J, Newton L, et al. Cyclosporine-associated chronic nephropathy. N Engl J Med 1984; 311: 699.
16. Masuda E, Imamura R, Amasaki Y, et al. Signalling into the T-cell nucleus: NFAT regulation. Cell Signal 1998; 10: 599.
17. Tumlin JA, Sands JM. Nephron segment-specific inhibition of Na+/K+-ATPase activity by cyclosporin A. Kidney Int 1993; 43: 246.
18. Tumlin JA, Someren JT, Swanson CE, Lea JP. Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. Am J Physiol (Renal Physiol) 1995; 269: F558.
19. Gooch JL, Guler RL, Barnes JL, Toro JJ. Loss of calcineurin A-alpha results in altered trafficking of AQP2 and is a new model of nephrogenic diabetes insipidus. J Cell Sci 2006; 119: 2468.
20. Chan VS, Wong C, Ohashi PS. Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not immature T cells. Eur J Immunol 2002; 32: 1223.
21. Islam M, Burke JF, Jr, McGowan TA, et al. Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction. Kidney Int 2001; 59: 498.
22. Wolf G, Thaiss F, Stahl RA. Cyclosporine stimulates expression of transforming growth factor-beta in renal cells. Possible mechanism of cyclosporines antiproliferative effects. Transplantation 1995; 60: 237.
23. Gooch JL. An emerging role for calcineurin Aalpha in the development and function of the kidney. Am J Physiol Renal Physiol 2006; 290: F769.