A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Fierro Monti, Ivo ^a   Racle, Julien ^b,c   Hernandez, Celine ^a,c   Waridel, Patrice ^a   Hatzimanikatis, Vassily ^b,c   Quadroni, Manfredo ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

^c SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90 INHIBITOR;

ARTICLE; CONTROLLED STUDY; EXPERIMENTAL DESIGN; ISOTOPE LABELING; LEUKEMIA CELL LINE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEOMICS; PULSE CHASE STABLE ISOTOPE LABELING BY AMINO ACIDS IN CELL CULTURE; QUALITY CONTROL; REPRODUCIBILITY;

CELL LINE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; ISOTOPE LABELING; KINETICS; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; PROTEOMICS;

EID: 84896723895     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080423     Document Type: Article

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