Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: A "smart" drug delivery system to breast cancer cell therapy

International Journal of Biological Macromolecules

Volumn 65, Issue , 2014, Pages 289-297

  Vivek, Raju ^a   Thangam, Ramar ^a,b   Nipunbabu, Varukattu ^a   Ponraj, Thondhi ^a   Kannan, Soundarapandian ^a,c  

^a BHARATHIAR UNIVERSITY   (India)

^b King Institute for Preventive Medicine and Research   (India)

^c PERIYAR UNIVERSITY   (India)

Author keywords

Chitosan nanoparticles; Drug release; In vitro; Intrinsic apoptotic pathway; MCF 7 cells; Oxaliplatin

Indexed keywords

CASPASE 3; CASPASE 9; CHITOSAN; CYTOCHROME C; NANOPARTICLE; ONCOPROTEIN; OXALIPLATIN; PROTEIN BAX; PROTEIN BIK; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG CARRIER; PLATINUM COMPLEX;

APOPTOSIS; ARTICLE; BIODEGRADABILITY; BREAST CANCER; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG DELIVERY SYSTEM; EMULSION; ENCAPSULATION; ENDOCYTOSIS; EVAPORATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROPHILICITY; IC 50; LIGHT SCATTERING; MITOCHONDRIAL MEMBRANE POTENTIAL; MORPHOLOGY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; BIOLOGICAL THERAPY; BREAST TUMOR; CHEMISTRY; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL- AND TISSUE-BASED THERAPY; CHITOSAN; DRUG CARRIERS; HUMANS; MCF-7 CELLS; NANOPARTICLES; ORGANOPLATINUM COMPOUNDS; SIGNAL TRANSDUCTION;

EID: 84896721486     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2014.01.054     Document Type: Article

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