Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: Preparation and controlled release characteristics

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 59, Issue 1, 2005, Pages 207-216

  Kockisch, Sandra ^a   Rees, Gareth D ^b   Tsibouklis, John ^c   Smart, John D ^d  

^a LILLY DEUTSCHLAND GMBH   (Germany)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^d UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

Bioadhesion; Double emulsion; Oral cavity; Polymer microspheres; Release kinetics; Triclosan

Indexed keywords

CARBOMER; CHITOSAN; DODECYL SULFATE SODIUM; GANTREZ COPOLYMER; POLYCARBOPHIL; TRICLOSAN;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG RELEASE; EMULSION; EVAPORATION; MOUTH CAVITY; MOUTH HYGIENE; PROCESS MODEL; SIMULATION; SUSTAINED DRUG RELEASE;

ADHESIVES; ADMINISTRATION, ORAL; DELAYED-ACTION PREPARATIONS; MICROSPHERES; MOUTH; POLYMERS; TRICLOSAN;

EID: 9644287768     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.07.007     Document Type: Article

References (19)

1. D. Steinberg, and M. Friedman Dental drug-delivery devices: local and sustained-release applications Crit. Rev. Therap. Drug Carrier Syst. 16 1999 425 459
2. L. Krowszynski Extended-release Dosage Forms 1987 CRC Press Boca Raton, FL
3. J.R. Robinson Sustained and Controlled Release Drug Delivery Systems 1978 Marcel Dekker New York
4. L. Yang, and P. Alexandridis Physicochemical aspects of drug delivery and release from polymer-based colloids. Current opinion Colloid Interf. Sci. 5 2000 132 143
5. A. Ahuja, R.K. Khar, and J. Ali Mucoadhesive drug delivery systems Drug Dev. Ind. Pharm. 23 1997 489 515
6. J.D. Smart Drug delivery using buccal adhesive systems Adv. Drug Deliv. Rev. 11 1993 253 270
7. D. Patel, A.W. Smith, N. Grist, P. Barnett, and J.D. Smart An in vitro mucosal model predictive of bioadhesive agents in the oral cavity J. Contr. Rel. 61 1999 175 183
8. S. Kockisch, G.D. Rees, S.A. Young, J. Tsibouklis, and J.D. Smart A direct-staining method to evaluate the adhesion of polymers from aqueous dispersion onto oral mucosal cells J. Contr. Rel. 77 2001 1 6
9. S. Kockisch, G.D. Rees, S.A. Young, J. Tsibouklis, and J.D. Smart Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential J. Pharm. Sci. 92 2003 1614 1623
10. S. Kockisch, G.D. Rees, S.A. Young, J. Tsibouklis, and J.D. Smart In-situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions Int. J. Pharm. 276 2004 51 58
11. H.N. Bhargava, and P.A. Leonardm Triclosan: applications and safety Am. J. Infect. Cont. 24 1996 209 218
12. J.E. Creeth, P.J. Abraham, J.A. Barlow, and D. Cummins Oral delivery and clearance of antiplaque agents from triclosan-containing dentifrices Int. Dent. J. 43 1993 387 397
13. R.J. Gilbert, and P.E.O. Williams The oral retention and antiplaque efficacy of triclosan in human volunteers Br. J. Clin. Pharm. 23 1987 579 583
14. H. Kawaguchi Functional polymer microspheres Prog. Polym. Sci. 25 2000 1171 1210
15. A. Li Wan Po, L.P. Wong, and C.A. Gilligan Characterisation of commercially available theophylline sustained- or controlled-release systems: in vitro drug release profiles Int. J. Pharm. 66 1990 111 130
16. A.W. Hixson, and J.H. Crowell Dependence of reaction velocity upon surface and agitation. I. Theoretical consideration Ind. Eng. Chem. 23 1931 923 931
17. T. Higuchi Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices J. Pharm. Sci. 52 1963 1145 1149
18. R.W. Baker, and H.K. Lonsdale Controlled release: mechanisms and rates A.C. Tanquary R.F. Lacey Controlled Release of Biologically Active Agents 1974 Plenum Press New York 15 71
19. J.D. Smart, M.S. Barnes, and M.J. Norris An in vitro comparison of controlled release aminophylline tablets: Phyllocontin Continus and Pecram J. Pharm. Pharmacol. 44 1992 623 625