Inhibition of Caspases protects mice from Radiation-induced Oral Mucositis and Abolishes the Cleavage of RNA-binding Protein HuR

Journal of Biological Chemistry

Volumn 289, Issue 6, 2014, Pages 3487-3500

  Talwar, Sudha ^a   House, Reniqua ^a   Sundaramurthy, Santhanalakshmi ^a   Balasubramanian, Sundaravadivel ^b   Yu, Hong ^a   Palanisamy, Viswanathan ^a  

^a Charleston   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PATHWAYS; EPITHELIAL CELL GROWTH; GENE EXPRESSION PATTERNS; MOLECULAR MECHANISM; POST-TRANSCRIPTIONAL REGULATIONS; PRO-APOPTOTIC FACTORS; PROTECTIVE EFFECTS; RNA-BINDING PROTEIN;

CELL DEATH; CHEMOTHERAPY; GENE EXPRESSION; IONIZING RADIATION; MAMMALS; RNA;

PROTEINS;

CASPASE 3; HUR PROTEIN; MESSENGER RNA; NSC 321205; PROTEIN BAX; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAX GENE; CELL GROWTH; CLONOGENESIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; KERATINOCYTE; MOUSE; NONHUMAN; ORAL MUCOSITIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RADIATION INJURY; RADIATION PROTECTION;

APOPTOSIS; CASPASE; ENZYME INHIBITORS; HUR; MRNA DECAY; MUCOSITIS; RNA-BINDING PROTEIN;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; GAMMA RAYS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; KERATINOCYTES; MICE; MOUTH MUCOSA; PROTEASE INHIBITORS; RADIATION INJURIES, EXPERIMENTAL; RNA, MESSENGER; STOMATITIS;

EID: 84896720318     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.504951     Document Type: Article

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