Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers

Neuropharmacology

Volumn 79, Issue , 2014, Pages 596-602

  Adwan, Lina ^a   Subaiea, Gehad M ^a   Zawia, Nasser H ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; BACE1; Pb; Sp1; Tolfenamic acid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BIOLOGICAL MARKER; DIMETHYL SULFOXIDE; GLUTAMINE; LEAD ACETATE; PENICILLIN DERIVATIVE; STREPTOMYCIN; TOLFENAMIC ACID; TRANSCRIPTION FACTOR SP1; ANTHRANILIC ACID DERIVATIVE; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; LEAD; NEUROPROTECTIVE AGENT; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APP GENE; ARTICLE; BACE1 GENE; BRAIN CORTEX; CELL DIFFERENTIATION; CELL VIABILITY; COGNITION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; UPREGULATION; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; GENETICS; LEAD POISONING, NERVOUS SYSTEM; METABOLISM; TOXICITY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CELL SURVIVAL; CEREBRAL CORTEX; FEMALE; HUMANS; LEAD; LEAD POISONING, NERVOUS SYSTEM; MICE; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; ORTHO-AMINOBENZOATES; SP1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84896720109     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.009     Document Type: Article

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