-
1
-
-
42949171158
-
-
Atlanta, GA: American Cancer Society 1
-
Garcia M, Jemal A, Ward E, Center M, Hao Y, et al. (2007) Global cancer facts & figures 2007. Atlanta, GA: American Cancer Society 1.
-
(2007)
Global cancer facts & figures 2007
-
-
Garcia, M.1
Jemal, A.2
Ward, E.3
Center, M.4
Hao, Y.5
-
2
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW, (2004) Cancer genes and the pathways they control. Nature medicine 10: 789-799.
-
(2004)
Nature Medicine
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
-
4
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
-
5
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068.
-
Nature
, vol.455
, pp. 1061-1068
-
-
-
6
-
-
69749086899
-
Identification of rare cancer driver mutations by network reconstruction
-
Torkamani A, Schork NJ, (2009) Identification of rare cancer driver mutations by network reconstruction. Genome research 19: 1570-1578.
-
(2009)
Genome Research
, vol.19
, pp. 1570-1578
-
-
Torkamani, A.1
Schork, N.J.2
-
7
-
-
77949446630
-
Automated network analysis identifies core pathways in glioblastoma
-
Cerami E, Demir E, Schultz N, Taylor BS, Sander C, (2010) Automated network analysis identifies core pathways in glioblastoma. PloS one 5: e8918.
-
(2010)
PloS One
, vol.5
-
-
Cerami, E.1
Demir, E.2
Schultz, N.3
Taylor, B.S.4
Sander, C.5
-
8
-
-
35348988164
-
Network analysis of oncogenic Ras activation in cancer
-
Stites EC, Trampont PC, Ma Z, Ravichandran KS, (2007) Network analysis of oncogenic Ras activation in cancer. Science 318: 463-467.
-
(2007)
Science
, vol.318
, pp. 463-467
-
-
Stites, E.C.1
Trampont, P.C.2
Ma, Z.3
Ravichandran, K.S.4
-
10
-
-
0034633702
-
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study
-
Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, et al. (2000) Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proceedings of the National Academy of Sciences of the United States of America 97: 11250-11255.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 11250-11255
-
-
Lev Bar-Or, R.1
Maya, R.2
Segel, L.A.3
Alon, U.4
Levine, A.J.5
-
11
-
-
84879076495
-
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
-
Chen X, Chen J, Gan S, Guan H, Zhou Y, et al. (2013) DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC biology 11: 73.
-
(2013)
BMC Biology
, vol.11
, pp. 73
-
-
Chen, X.1
Chen, J.2
Gan, S.3
Guan, H.4
Zhou, Y.5
-
12
-
-
78650386155
-
Decision making of the p53 network: Death by integration
-
doi:10.1016/j.jtbi.2010.11.041
-
Li Z, Ni M, Li J, Zhang Y, Ouyang Q, et al. (2010) Decision making of the p53 network: Death by integration. Journal of theoretical biology doi: 10.1016/j.jtbi.2010.11.041.
-
(2010)
Journal of Theoretical Biology
-
-
Li, Z.1
Ni, M.2
Li, J.3
Zhang, Y.4
Ouyang, Q.5
-
13
-
-
33646794425
-
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
-
Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, et al. (2006) Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell death and differentiation 13: 927-934.
-
(2006)
Cell Death and Differentiation
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
-
14
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D, Oren M, (2003) The p53-Mdm2 module and the ubiquitin system. Seminars in cancer biology 13: 49-58.
-
(2003)
Seminars in Cancer Biology
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
15
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab NH, Malikzay A, Appel M, Halazonetis TD, (2000) Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 14: 278-288.
-
(2000)
Genes Dev
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
16
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
Stommel JM, Wahl GM, (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. Embo J 23: 1547-1556.
-
(2004)
Embo J
, vol.23
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
18
-
-
34249336767
-
Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
-
Salmena L, Pandolfi PP, (2007) Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation. Nat Rev Cancer 7: 409-413.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 409-413
-
-
Salmena, L.1
Pandolfi, P.P.2
-
19
-
-
33646756222
-
Dissecting p53-dependent apoptosis
-
Chipuk JE, Green DR, (2006) Dissecting p53-dependent apoptosis. Cell Death Differ 13: 994-1002.
-
(2006)
Cell Death Differ
, vol.13
, pp. 994-1002
-
-
Chipuk, J.E.1
Green, D.R.2
-
20
-
-
0036716281
-
The Bcl2 family: regulators of the cellular life-or-death switch
-
Cory S, Adams JM, (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nature reviews Cancer 2: 647-656.
-
(2002)
Nature Reviews Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
21
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-1014.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
-
22
-
-
0034123026
-
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
-
Slee EA, Keogh SA, Martin SJ, (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell death and differentiation 7: 556-565.
-
(2000)
Cell Death and Differentiation
, vol.7
, pp. 556-565
-
-
Slee, E.A.1
Keogh, S.A.2
Martin, S.J.3
-
23
-
-
26444489119
-
Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis
-
Spierings D, McStay G, Saleh M, Bender C, Chipuk J, et al. (2005) Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 310: 66-67.
-
(2005)
Science
, vol.310
, pp. 66-67
-
-
Spierings, D.1
McStay, G.2
Saleh, M.3
Bender, C.4
Chipuk, J.5
-
24
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu JI, Dumont P, Hafey M, Murphy ME, George DL, (2004) Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature cell biology 6: 443-450.
-
(2004)
Nature Cell Biology
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
Dumont, P.2
Hafey, M.3
Murphy, M.E.4
George, D.L.5
-
25
-
-
26444583906
-
A plausible model for the digital response of p53 to DNA damage
-
Ma L, Wagner J, Rice JJ, Hu W, Levine AJ, et al. (2005) A plausible model for the digital response of p53 to DNA damage. Proceedings of the National Academy of Sciences of the United States of America 102: 14266-14271.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 14266-14271
-
-
Ma, L.1
Wagner, J.2
Rice, J.J.3
Hu, W.4
Levine, A.J.5
-
26
-
-
33846594408
-
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis
-
Zhang T, Brazhnik P, Tyson JJ, (2007) Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis. Cell Cycle 6: 85-94.
-
(2007)
Cell Cycle
, vol.6
, pp. 85-94
-
-
Zhang, T.1
Brazhnik, P.2
Tyson, J.J.3
-
27
-
-
42949171936
-
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
-
Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G, (2008) Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Molecular cell 30: 277-289.
-
(2008)
Molecular Cell
, vol.30
, pp. 277-289
-
-
Batchelor, E.1
Mock, C.S.2
Bhan, I.3
Loewer, A.4
Lahav, G.5
-
28
-
-
34447114459
-
Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays
-
Ramalingam S, Honkanen P, Young L, Shimura T, Austin J, et al. (2007) Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays. Cancer research 67: 6247-6252.
-
(2007)
Cancer Research
, vol.67
, pp. 6247-6252
-
-
Ramalingam, S.1
Honkanen, P.2
Young, L.3
Shimura, T.4
Austin, J.5
-
29
-
-
32544442894
-
Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress
-
Speidel D, Helmbold H, Deppert W, (2006) Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene 25: 940-953.
-
(2006)
Oncogene
, vol.25
, pp. 940-953
-
-
Speidel, D.1
Helmbold, H.2
Deppert, W.3
-
30
-
-
33847066734
-
A systems biology dynamical model of mammalian G1 cell cycle progression
-
Haberichter T, Madge B, Christopher RA, Yoshioka N, Dhiman A, et al. (2007) A systems biology dynamical model of mammalian G1 cell cycle progression. Mol Syst Biol 3: 84.
-
(2007)
Mol Syst Biol
, vol.3
, pp. 84
-
-
Haberichter, T.1
Madge, B.2
Christopher, R.A.3
Yoshioka, N.4
Dhiman, A.5
-
31
-
-
0037302108
-
Regulation of the mammalian cell cycle: a model of the G1-to-S transition
-
Qu Z, Weiss JN, MacLellan WR, (2003) Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol 284: C349-364.
-
(2003)
Am J Physiol Cell Physiol
, vol.284
-
-
Qu, Z.1
Weiss, J.N.2
MacLellan, W.R.3
-
32
-
-
34347381069
-
Irreversible cell-cycle transitions are due to systems-level feedback
-
Novak B, Tyson JJ, Gyorffy B, Csikasz-Nagy A, (2007) Irreversible cell-cycle transitions are due to systems-level feedback. Nat Cell Biol 9: 724-728.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 724-728
-
-
Novak, B.1
Tyson, J.J.2
Gyorffy, B.3
Csikasz-Nagy, A.4
-
33
-
-
43149108161
-
A bistable Rb-E2F switch underlies the restriction point
-
Yao G, Lee TJ, Mori S, Nevins JR, You L, (2008) A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 10: 476-482.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 476-482
-
-
Yao, G.1
Lee, T.J.2
Mori, S.3
Nevins, J.R.4
You, L.5
-
34
-
-
57549098807
-
The Catalogue of Somatic Mutations in Cancer (COSMIC)
-
Unit 10 11, Chapter 10
-
Forbes SA, Bhamra G, Bamford S, Dawson E, Kok C, et al. (2008) The Catalogue of Somatic Mutations in Cancer (COSMIC). Current protocols in human genetics/editorial board, Jonathan L Haines [et al] Chapter 10: Unit 10 11.
-
(2008)
Current Protocols in Human Genetics/Editorial Board, Jonathan L Haines [Et Al]
-
-
Forbes, S.A.1
Bhamra, G.2
Bamford, S.3
Dawson, E.4
Kok, C.5
-
35
-
-
64049118136
-
From cancer genomes to cancer models: bridging the gaps
-
Baudot A, Real FX, Izarzugaza JM, Valencia A, (2009) From cancer genomes to cancer models: bridging the gaps. EMBO reports 10: 359-366.
-
(2009)
EMBO Reports
, vol.10
, pp. 359-366
-
-
Baudot, A.1
Real, F.X.2
Izarzugaza, J.M.3
Valencia, A.4
-
36
-
-
8944244998
-
Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
-
Sakakura C, Sweeney EA, Shirahama T, Igarashi Y, Hakomori S, et al. (1996) Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. International journal of cancer Journal international du cancer 67: 101-105.
-
(1996)
International Journal of Cancer Journal International Du Cancer
, vol.67
, pp. 101-105
-
-
Sakakura, C.1
Sweeney, E.A.2
Shirahama, T.3
Igarashi, Y.4
Hakomori, S.5
-
37
-
-
0034717014
-
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
-
Marchenko ND, Zaika A, Moll UM, (2000) Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. The Journal of biological chemistry 275: 16202-16212.
-
(2000)
The Journal of Biological Chemistry
, vol.275
, pp. 16202-16212
-
-
Marchenko, N.D.1
Zaika, A.2
Moll, U.M.3
-
38
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, et al. (2003) p53 has a direct apoptogenic role at the mitochondria. Molecular cell 11: 577-590.
-
(2003)
Molecular Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
-
39
-
-
84858158794
-
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
-
Dewson G, Ma S, Frederick P, Hockings C, Tan I, et al. (2012) Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell death and differentiation 19: 661-670.
-
(2012)
Cell Death and Differentiation
, vol.19
, pp. 661-670
-
-
Dewson, G.1
Ma, S.2
Frederick, P.3
Hockings, C.4
Tan, I.5
-
41
-
-
0035522894
-
Two genetic hits (more or less) to cancer
-
Knudson AG, (2001) Two genetic hits (more or less) to cancer. Nature reviews Cancer 1: 157-162.
-
(2001)
Nature Reviews Cancer
, vol.1
, pp. 157-162
-
-
Knudson, A.G.1
-
42
-
-
55849099654
-
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
-
Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, et al. (2008) Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proceedings of the National Academy of Sciences 105: 16224.
-
(2008)
Proceedings of the National Academy of Sciences
, vol.105
, pp. 16224
-
-
Leary, R.J.1
Lin, J.C.2
Cummins, J.3
Boca, S.4
Wood, L.D.5
-
43
-
-
34547566118
-
CanPredict: a computational tool for predicting cancer-associated missense mutations
-
Kaminker JS, Zhang Y, Watanabe C, Zhang Z, (2007) CanPredict: a computational tool for predicting cancer-associated missense mutations. Nucleic acids research 35: W595-W598.
-
(2007)
Nucleic Acids Research
, vol.35
-
-
Kaminker, J.S.1
Zhang, Y.2
Watanabe, C.3
Zhang, Z.4
-
44
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, et al. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446: 153-158.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
-
45
-
-
27244451471
-
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback
-
Wagner J, Ma L, Rice JJ, Hu W, Levine AJ, et al. (2005) p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. Syst Biol (Stevenage) 152: 109-118.
-
(2005)
Syst Biol (Stevenage)
, vol.152
, pp. 109-118
-
-
Wagner, J.1
Ma, L.2
Rice, J.J.3
Hu, W.4
Levine, A.J.5
-
46
-
-
25444513462
-
Steady states and oscillations in the p53/Mdm2 network
-
Ciliberto A, Novak B, Tyson JJ, (2005) Steady states and oscillations in the p53/Mdm2 network. Cell Cycle 4: 488-493.
-
(2005)
Cell Cycle
, vol.4
, pp. 488-493
-
-
Ciliberto, A.1
Novak, B.2
Tyson, J.J.3
-
47
-
-
34047247060
-
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells
-
Hu W, Feng Z, Ma L, Wagner J, Rice JJ, et al. (2007) A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res 67: 2757-2765.
-
(2007)
Cancer Res
, vol.67
, pp. 2757-2765
-
-
Hu, W.1
Feng, Z.2
Ma, L.3
Wagner, J.4
Rice, J.J.5
-
48
-
-
38549145044
-
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
-
Letai AG, (2008) Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nature reviews Cancer 8: 121-132.
-
(2008)
Nature Reviews Cancer
, vol.8
, pp. 121-132
-
-
Letai, A.G.1
-
49
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, et al. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Molecular cell 17: 393-403.
-
(2005)
Molecular Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
-
51
-
-
33750533388
-
Physicochemical modelling of cell signalling pathways
-
Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK, (2006) Physicochemical modelling of cell signalling pathways. Nature cell biology 8: 1195-1203.
-
(2006)
Nature Cell Biology
, vol.8
, pp. 1195-1203
-
-
Aldridge, B.B.1
Burke, J.M.2
Lauffenburger, D.A.3
Sorger, P.K.4
|