Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Dong, Jing ^a   Xu, Huan ^a   Wang, Peng Fei ^a   Cai, Gui Ju ^a   Song, Hai Feng ^a   Wang, Chang Chen ^a   Dong, Zhao Tong ^a   Ju, Yan Jiao ^a   Jiang, Zheng Yao ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; NESFATIN 1; REGULATOR PROTEIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVATION; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FATTY ACIDS, NONESTERIFIED; GASTRIC MUCOSA; HYPOTHALAMUS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; PHOSPHORYLATION; STREPTOZOCIN;

EID: 84896714261     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083397     Document Type: Article

References (30)

1. Oh I, Shimizu H, Satoh T, Okada S, Adachi S, et al. (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus, Nature. 443, 709-712. (Pubitemid 44564715)
2. Gonzalez R, Perry RL, Gao X, Gaidhu MP, Tsushima RG, et al. (2011) Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats 1, Endocrinology. 152, 3628-3637.
3. Pan W, Hsuchou H, Kastin AJ (2007) Nesfatin-1 crosses the blood-brain barrier without saturation, Peptides. 28, 2223-2228. (Pubitemid 47600423)
4. Price TO, Samson WK, Niehoff ML, Banks WA (2007) Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1, Peptides. 28, 2372-81. (Pubitemid 350123562)
5. Gantulga D, Maejima Y, Nakata M, Yada T (2012) Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus, Biochemical and biophysical research communications. 420, 811-5.
6. Goebel-Stengel M, Wang L (2013) Central And Peripheral Expression And Distribution Of NUBC2/Nesfatin-1, Current pharmaceutical design.
7. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, et al. (2010) Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity, Endocrinology. 151, 3169-80.
8. Su Y, Zhang J, Tang Y, Bi F, Liu JN (2010) The novel function of nesfatin-1: anti-hyperglycemia, Biochem Biophys Res Commun. 391, 1039-1042.
9. Nakata M, Manaka K, Yamamoto S, Mori M, Yada T (2011) Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet beta-cells, EndocrJ. 58, 305-313.
10. Li QC, Wang HY, Chen X, Guan HZ, Jiang ZY (2010) Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans, Regulatory peptides. 159, 72-7.
11. Zhang Z, Li L, Yang M, Liu H, Boden G, et al. (2012) Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus, Exp Clin Endocrinol Diabetes. 120, 91-95.
12. Riva M, Nitert MD, Voss U, Sathanoori R, Lindqvist A, et al. (2011) Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects, Cell and tissue research. 346, 393-405.
13. Foo KS, Brauner H, Ostenson CG, Broberger C (2010) Nucleobindin-2/ nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state 1, JEndocrinol.204, 255-263.
14. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature. 415, 339-43. (Pubitemid 34087557)
15. Chow L, From A, Seaquist E (2010) Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction, Metabolism. 59, 70-85.
16. Yang M, Zhang Z, Wang C, Li K, Li S, et al. (2012) Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance 1, Diabetes. 61, 1959-1968.
17. Xue B, Kahn BB (2006) AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues, JPhysiol.574, 73-83. (Pubitemid 43905798)
18. Bikman BT, Zheng D, Kane DA, Anderson EJ, Woodlief TL, et al. (2010) Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKbeta Action in a Fiber-Type Specific Manner, Journal of obesity. 2010.
19. Xia Y, Li Q, Zhong W, Dong J, Wang Z, et al. (2011) L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function 1, Diabetol Metab Syndr. 3, 31.
20. Poucher SM, Cheetham S, Francis J, Zinker B, Kirby M, et al. (2012) Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic beta-cell mass in a streptozotocin-induced mouse model of type 2 diabetes, Diabetes, obesity and metabolism. 14, 918-26.
21. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, et al. (2000) A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat, Metabolism. 49, 1390-4.
22. Muniyappa R, Lee S, Chen H, Quon MJ (2008) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage 2, Am J Physiol EndocrinolMetab. 294, E15-E26.
23. Kim JE, Lee MH, Nam DH, Song HK, Kang YS, et al. (2013) Celastrol, an NF-kappaB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice, PloS one. 8, e62068.
24. Atkinson BJ, Griesel BA, King CD, Josey MA, Olson AL (2013) Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high fat fed transgenic mice, Diabetes.
25. Luo J, Quan J, Tsai J, Hobensack CK, Sullivan C, et al. (1998) Nongenetic mouse models of non-insulin-dependent diabetes mellitus, Metabolism. 47, 663-8. (Pubitemid 28265168)
26. Abbott MJ, Constantinescu S, Turcotte LP (2012) AMP-activated protein kinase alpha2 is an essential signal in the regulation of insulin-stimulated fatty acid uptake in control-fed and high-fat-fed mice, ExpPhysiol. 97, 603-617.
27. Ruderman NB, Saha AK, Vavvas D, Witters LA (1999) Malonyl-CoA, fuel sensing, and insulin resistance 43, AmJPhysiol. 276, E1-E18. (Pubitemid 29065588)
28. Viollet B, Andreelli F, Jorgensen SB, Perrin C, Geloen A, et al. (2003) The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity, JClinInvest. 111, 91-98. (Pubitemid 36134852)
29. Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, et al. (2007) Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain 2, Endocrinology. 148, 5088-5094. (Pubitemid 47481535)
30. Camina JP, Carreira MC, El MS, Llorens-Cortes C, Smith RG, et al. (2004) Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a 1, Endocrinology. 145, 930-940. (Pubitemid 38183837)