TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFκB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells

Food and Chemical Toxicology

Volumn 66, Issue , 2014, Pages 56-64

  Park, Chung Mu ^a   Cho, Chung Won ^b   Song, Young Sun ^b  

^a Dong Eui University   (South Korea)

^b Inje University   (South Korea)

Author keywords

Anti inflammatory; Antioxidative; NF B; Nrf2; PI3KAkt; Taraxacum officinale polysaccharide

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; HEME OXYGENASE 1; HEME OXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; POLYSACCHARIDE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TARAXACUM OFFICINALE EXTRACT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NFE2L2 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; INFLAMMATION; INTRACELLULAR SIGNALING; MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; TREATMENT OUTCOME; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DANDELION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CELL LINE; HEME OXYGENASE-1; INFLAMMATION; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TARAXACUM;

EID: 84896711886     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.01.019     Document Type: Article

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