메뉴 건너뛰기




Volumn 37, Issue 2, 2014, Pages 662-671

Therapeutic potential of morin against liver fibrosis in rats: Modulation of oxidative stress, cytokine production and nuclear factor kappa B

Author keywords

Carbon tetrachloride; Liver fibrosis; Morin; Nuclear factor kappa B; Oxidative stress; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MESSENGER RNA; MORIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SILYMARIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CARBON TETRACHLORIDE; FLAVONOID; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; PROTECTIVE AGENT;

EID: 84896710299     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.01.026     Document Type: Article
Times cited : (60)

References (33)
  • 1
    • 1542374060 scopus 로고    scopus 로고
    • Signal transduction via the NF-κB pathway: a targeted treatment modality for infection inflammation and repair
    • Ali S., Mann D.A. Signal transduction via the NF-κB pathway: a targeted treatment modality for infection inflammation and repair. Cell Biochem. Funct. 2004, 22:67-79.
    • (2004) Cell Biochem. Funct. , vol.22 , pp. 67-79
    • Ali, S.1    Mann, D.A.2
  • 2
    • 84856226251 scopus 로고    scopus 로고
    • Pretreatment with morin, a flavonoid, ameliorates adenosine triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
    • Al-Numair K.S., Chandramohan G., Alsaif M.A. Pretreatment with morin, a flavonoid, ameliorates adenosine triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats. J. Nat. Med. 2012, 66:95-101.
    • (2012) J. Nat. Med. , vol.66 , pp. 95-101
    • Al-Numair, K.S.1    Chandramohan, G.2    Alsaif, M.A.3
  • 3
    • 73649194769 scopus 로고
    • Improved method for determination of blood glutathione
    • Beutler E., Duron O., Kelly M.B. Improved method for determination of blood glutathione. J. Lab. Clin. Med. 1963, 61:882-887.
    • (1963) J. Lab. Clin. Med. , vol.61 , pp. 882-887
    • Beutler, E.1    Duron, O.2    Kelly, M.B.3
  • 4
    • 84862779593 scopus 로고    scopus 로고
    • Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes
    • Chen W.P., Wang Y.L., Tang J.L., Hu P.F., Bao J.P., Wu L.D. Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Int. Immunopharmacol. 2012, 12:447-452.
    • (2012) Int. Immunopharmacol. , vol.12 , pp. 447-452
    • Chen, W.P.1    Wang, Y.L.2    Tang, J.L.3    Hu, P.F.4    Bao, J.P.5    Wu, L.D.6
  • 5
    • 0031742173 scopus 로고    scopus 로고
    • Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes
    • Johnston D.E., Kroening C. Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes. Pharmacol. Toxicol. 1998, 83:231-239.
    • (1998) Pharmacol. Toxicol. , vol.83 , pp. 231-239
    • Johnston, D.E.1    Kroening, C.2
  • 6
    • 77949480939 scopus 로고    scopus 로고
    • Morin modulates the oxidative stress-induced NF-κB pathway through its anti-oxidant activity
    • Kim J.M., Lee E.K., Park G., Kim M.K., Yokozawa T., Yu B.P., Chung H.Y. Morin modulates the oxidative stress-induced NF-κB pathway through its anti-oxidant activity. Free Radic. Res. 2010, 44:454-461.
    • (2010) Free Radic. Res. , vol.44 , pp. 454-461
    • Kim, J.M.1    Lee, E.K.2    Park, G.3    Kim, M.K.4    Yokozawa, T.5    Yu, B.P.6    Chung, H.Y.7
  • 7
    • 16644374042 scopus 로고    scopus 로고
    • Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin
    • Kitagawa S., Sakamoto H., Tano H. Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin. Chem. Pharm. Bull. 2004, 52:999-1001.
    • (2004) Chem. Pharm. Bull. , vol.52 , pp. 999-1001
    • Kitagawa, S.1    Sakamoto, H.2    Tano, H.3
  • 10
    • 79751492851 scopus 로고    scopus 로고
    • NF-κB in the liver-linking injury fibrosis and hepatocellular carcinoma
    • Luedde T., Schwabe R.F. NF-κB in the liver-linking injury fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 2011, 8:108-118.
    • (2011) Nat. Rev. Gastroenterol. Hepatol. , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 12
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 13
    • 23744479064 scopus 로고    scopus 로고
    • Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator activated receptors in carbon tetrachloride-induced chronic liver injury in rats
    • Orfila C., Lepert J.C., Alric L., Carrera G., Beraud M., Pipy B. Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator activated receptors in carbon tetrachloride-induced chronic liver injury in rats. Histochem. Cell Biol. 2005, 123:585-593.
    • (2005) Histochem. Cell Biol. , vol.123 , pp. 585-593
    • Orfila, C.1    Lepert, J.C.2    Alric, L.3    Carrera, G.4    Beraud, M.5    Pipy, B.6
  • 14
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M., Robino G. Oxidative stress-related molecules and liver fibrosis. J. Hepatol. 2001, 35:297-306.
    • (2001) J. Hepatol. , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 15
    • 3543098600 scopus 로고    scopus 로고
    • Liver fibrosis: from the bench to clinical targets
    • Pinzani M., Rombouts K. Liver fibrosis: from the bench to clinical targets. Dig. Liver Dis. 2004, 36:231-242.
    • (2004) Dig. Liver Dis. , vol.36 , pp. 231-242
    • Pinzani, M.1    Rombouts, K.2
  • 16
    • 85044690309 scopus 로고    scopus 로고
    • Effect of morin a flavonoid against DOCA-salt hypertensive rats: a dose dependent study
    • Prahalathan P., Kumar S., Raja B. Effect of morin a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac. J. Trop. Biomed. 2012, 2:443-448.
    • (2012) Asian Pac. J. Trop. Biomed. , vol.2 , pp. 443-448
    • Prahalathan, P.1    Kumar, S.2    Raja, B.3
  • 17
    • 33644544110 scopus 로고    scopus 로고
    • The liver as an immunological organ
    • Racanelli V., Rehermann B. The liver as an immunological organ. Hepatology 2006, 43:S54-S62.
    • (2006) Hepatology , vol.43
    • Racanelli, V.1    Rehermann, B.2
  • 18
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller R., Meier R., Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 2001, 61:2035-2063.
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 20
    • 0036629201 scopus 로고    scopus 로고
    • Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy
    • Sastry H., Moudgal R.P., Mohan J., Tyagi J.S., Rao G.S. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal. Biochem. 2002, 306:79-82.
    • (2002) Anal. Biochem. , vol.306 , pp. 79-82
    • Sastry, H.1    Moudgal, R.P.2    Mohan, J.3    Tyagi, J.S.4    Rao, G.S.5
  • 22
    • 67349224725 scopus 로고    scopus 로고
    • Morin regulates the expression of NF-κB-p65 COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma
    • Sivaramakrishnan V., Devaraj S.N. Morin regulates the expression of NF-κB-p65 COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem. Biol. Interact. 2009, 180:353-359.
    • (2009) Chem. Biol. Interact. , vol.180 , pp. 353-359
    • Sivaramakrishnan, V.1    Devaraj, S.N.2
  • 23
    • 72149083011 scopus 로고    scopus 로고
    • Morin fosters apoptosis in experimental hepatocellular carcinogenesis model
    • Sivaramakrishnan V., Devaraj S.N. Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. Chem. Biol. Interact. 2010, 183:284-292.
    • (2010) Chem. Biol. Interact. , vol.183 , pp. 284-292
    • Sivaramakrishnan, V.1    Devaraj, S.N.2
  • 26
    • 67349208238 scopus 로고    scopus 로고
    • Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study
    • Subash S., Subramanian P. Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study. Mol. Cell. Biochem. 2009, 327:153-161.
    • (2009) Mol. Cell. Biochem. , vol.327 , pp. 153-161
    • Subash, S.1    Subramanian, P.2
  • 27
    • 77950860535 scopus 로고    scopus 로고
    • Antifibrotic therapies: will we ever get there?
    • Thompson A.J., Patel K. Antifibrotic therapies: will we ever get there?. Curr. Gastroenterol. Rep. 2010, 12:23-29.
    • (2010) Curr. Gastroenterol. Rep. , vol.12 , pp. 23-29
    • Thompson, A.J.1    Patel, K.2
  • 29
    • 33745996622 scopus 로고
    • The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
    • Woessner J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 1961, 93:440-447.
    • (1961) Arch. Biochem. Biophys. , vol.93 , pp. 440-447
    • Woessner, J.F.1
  • 30
    • 77956567009 scopus 로고    scopus 로고
    • Protective effects of vitamin e analogs against carbon tetrachloride-induced fatty liver in rats
    • Yachi R., Igarashi O., Kiyose C. Protective effects of vitamin e analogs against carbon tetrachloride-induced fatty liver in rats. J. Clin. Biochem. Nutr. 2010, 47:148-154.
    • (2010) J. Clin. Biochem. Nutr. , vol.47 , pp. 148-154
    • Yachi, R.1    Igarashi, O.2    Kiyose, C.3
  • 31
    • 68549133289 scopus 로고    scopus 로고
    • Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats
    • Yuvaraj P., Subramoniam A. Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats. J. Basic Clin. Physiol. Pharmacol. 2009, 20:169-177.
    • (2009) J. Basic Clin. Physiol. Pharmacol. , vol.20 , pp. 169-177
    • Yuvaraj, P.1    Subramoniam, A.2
  • 32
    • 84875913089 scopus 로고    scopus 로고
    • Recent advances in natural products from plants for treatment of liver diseases
    • Zhang A., Sun H., Wang X. Recent advances in natural products from plants for treatment of liver diseases. Eur. J. Med. Chem. 2013, 63:570-577.
    • (2013) Eur. J. Med. Chem. , vol.63 , pp. 570-577
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 33
    • 78650194976 scopus 로고    scopus 로고
    • Morin (2',3,4',5,7-pentahydroxyflavone) protected cells against radiation-induced oxidative stress
    • Zhang R., Kang K.A., Kang S.S., Park J.W., Hyun J.W. Morin (2',3,4',5,7-pentahydroxyflavone) protected cells against radiation-induced oxidative stress. Basic Clin. Pharmacol. Toxicol. 2011, 108:63-72.
    • (2011) Basic Clin. Pharmacol. Toxicol. , vol.108 , pp. 63-72
    • Zhang, R.1    Kang, K.A.2    Kang, S.S.3    Park, J.W.4    Hyun, J.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.