4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 53-60

  Baruchello, Riccardo ^a   Simoni, Daniele ^a   Marchetti, Paolo ^a   Rondanin, Riccardo ^a   Mangiola, Stefania ^a   Costantini, Cristiana ^a   Meli, Maria ^b   Giannini, Giuseppe ^c   Vesci, Loredana ^c   Carollo, Valeria ^c   Brunetti, Tiziana ^c   Battistuzzi, Gianfranco ^c   Tolomeo, Manlio ^b   Cabri, Walter ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c Sigma Tau SpA   (Italy)

Author keywords

4 5 6 7 Tetrahydro isoxazolo 4 5 c pyridines; Anti cancer drugs; Heat shock protein 90

Indexed keywords

5 (2,4 BIS (BENZYLOXY) 5 ISOPROPYLBENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID; 5 (2,4 DIACETOXY 5 ISOPROPYLBENZOYL) N ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXAMIDE; 5 (2,4 DIHYDROXY 5 ISOPROPYL BENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID (2 MORPHOLIN 4 YL ETHYL) AMIDE; 5 (2,4 DIHYDROXY 5 ISOPROPYL BENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID CYCLOPENTYLAMIDE; 5 (2,4 DIHYDROXY 5 ISOPROPYL BENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID(2 CHLORO ETHYL) AMIDE; 5 (2,4 DIHYDROXY 5 ISOPROPYL BENZOYL) N [7 (HYDROXYAMINO) 7 OXO HEPTYL] 6,7 DIHYDRO 4H ISOXAZOLO[4,5 C]PYRIDINE 3 CARBOXAMIDE; 5 (2,4 DIHYDROXY 5 ISOPROPYLBENZOYL) N ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXAMIDE; 5 (2,4 DIHYDROXY BENZOYL) N ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXAMIDE; 5 (5 CHLORO 2,4 DIHYDROXYBENZOYL) N ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXAMIDE; AMIDE; CYTOTOXIC AGENT; ETHYL 5 (2,4 DIHYDROXY 5 ISOPROPYLBENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID; ETHYL 5 (2,4 DIHYDROXYBENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID; ETHYL 5 (5 CHLORO 2,4 DIHYDROXYBENZOYL) 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXYLIC ACID; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE; METHYL 7 [(5 (2,4 DIHYDROXY 5 ISOPROPYL BENZOYL) 6,7 DIHYDRO 4H ISOXAZOLO[4,5 C]PYRIDINE 3 CARBOXAMIDO) HEPTANOIC ACID; N 5 (2,4 DIHYDROXY 5 ISOPROPYLPHENYL) N 3 ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3,5(4H) DICARBOXAMIDE; N 5 (5 CHLORO 2,4 DIHYDROXYPHENYL) N 3 ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3,5(4H) DICARBOXAMIDE; N ETHYL 4,5,6,7 TETRAHYDROISOXAZOLE[4,5 C]PYRIDINE 3 CARBOXAMIDE; PYRIDINE DERIVATIVE; RESORCINOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN K 562; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; IC 50; LUNG SMALL CELL CANCER; ANTAGONISTS AND INHIBITORS; CELL DIVISION; CHEMISTRY; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; K562 CELL LINE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

APOPTOSIS; CELL DIVISION; FLOW CYTOMETRY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84896702711     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.056     Document Type: Article

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