Wnt/β-catenin signaling pathway may regulate the expression of angiogenic growth factors in hepatocellular carcinoma

Oncology Letters

Volumn 7, Issue 4, 2014, Pages 1175-1178

  Qu, Bo ^a   Liu, Bing Rong ^a   Du, Ya Ju ^a   Chen, Jing ^a   Cheng, Yan Qiu ^a   Xu, Wei ^a   Wang, Xin Hong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

catenin; Angiogenesis factor; Hepatocellular carcinoma; RNA interference; Signaling pathway

Indexed keywords

ANGIOGENIC FACTOR; BETA CATENIN; FIBROBLAST GROWTH FACTOR 2; GELATINASE A; GELATINASE B; SMALL INTERFERING RNA; VASCULOTROPIN A; VASCULOTROPIN C; WNT PROTEIN;

ANGIOGENESIS; ARTICLE; CANCER INFILTRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

EID: 84896702643     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1828     Document Type: Article

References (34)

1. Tsao CM, Yan MD, Shih YL, et al: SOX1 functions as a tumor suppressor by antagonizing the WNT{combining long solidus overlay}β-catenin signaling pathway in hepatocellular carcinoma. Hepatology 56: 2277-2287, 2012.
2. Jiang H, Xia J, Kang J, Ding Y and Wu W: Short hairpin RNA targeting beta-catenin suppresses cell proliferation and induces apoptosis in human gastric carcinoma cells. Scand J Gastroenterol 44: 1452-1462, 2009.
3. Yoo NJ, Kim S and Lee SH: Mutational analysis of WTX gene in Wnt{combining long solidus overlay} beta-catenin pathway in gastric, colorectal, and hepatocellular carcinomas. Dig Dis Sci 54: 1011-1014, 2009.
4. Mukherjee N, Bhattacharya N, Alam N, Roy A, Roychoudhury S and Panda CK: Subtype-specific alterations of the Wnt signaling pathway in breast cancer: clinical and prognostic significance. Cancer Sci 103: 210-220, 2012.
5. Kang YJ, Park HJ, Chung HJ, et al: Wnt{combining long solidus overlay}β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. Mol Pharmacol 82: 168-177, 2012.
6. Scholer-Dahirel A, Schlabach MR, Loo A, et al: Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt{combining long solidus overlay}beta-catenin signaling. Proc Natl Acad Sci USA 108: 17135-17140, 2011.
7. Bjorklund CC, Ma W, Wang ZQ, et al: Evidence of a role for activation of Wnt{combining long solidus overlay}beta-catenin signaling in the resistance of plasma cells to lenalidomide. J Biol Chem 286: 11009-11020, 2011.
8. Gehrke I, Gandhirajan RK and Kreuzer KA: Targeting the WNT{combining long solidus overlay}beta-catenin{combining long solidus overlay}TCF{combining long solidus overlay}LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options. Eur J Cancer 45: 2759-2767, 2009.
9. Wang X, Meng X, Sun X, et al: Wnt{combining long solidus overlay}β-catenin signaling pathway may regulate cell cycle and expression of cyclin A and cyclin E protein in hepatocellular carcinoma cells. Cell Cycle 8: 1567-1570, 2009.
10. Tannock IF: The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer 22: 258-273,1968.
11. Li C, Liu B, Dai Z and Tao Y: Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC). Cancer Biol Ther 12: 872-880, 2011.
12. Man K, Ng KT, Xu A, et al: Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase{combining long solidus overlay}IFN-inducible protein 10/matrix metalloproteinase 9 signaling. Clin Cancer Res 16: 967-977, 2010.
13. Hu J, Chen C, Su Y, Qian X and Jin Y: Vascular endothelial growth factor promotes the expression of cyclooxygenase 2 and matrix metalloproteinases in Lewis lung carcinoma cells. Exp Ther Med 4: 1045-1050, 2012.
14. Cole M and Bromberg M: Tissue factor as a novel target for treatment of breast cancer. Oncologist 18: 14-18, 2013.
15. Hamed EA, Zakhary MM and Maximous DW: Apoptosis, angiogenesis, inflammation, and oxidative stress: basic interactions in patients with early and metastatic breast cancer. J Cancer Res Clin Oncol 138: 999-1009, 2012.
16. Cattaruzza S, Ozerdem U, Denzel M, et al: Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells. Angiogenesis 16: 309-327, 2013.
17. Calviello G, Resci F, Serini S, et al: Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis 28: 1202-1209, 2007.
18. Stockmann C, Kerdiles Y, Nomaksteinsky M, et al: Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 107: 4329-4334, 2010.
19. Blavier L, Lazaryev A, Shi XH, Dorey FJ, Shackleford GM and DeClerck YA: Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther 10: 198-208, 2010.
20. Wu B, Crampton SP and Hughes CC: Wnt signaling induces MMP expression and regulates T cell transmigration. Immunity 26: 227-239, 2007.
21. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811, 1998.
22. Hannon GJ: RNA interference. Nature 418: 244-251, 2002.
23. Guo S, Colbert LS, Fuller M, Zhang Y and Gonzalez-Perez RR: Vascular endothelial growth factor receptor-2 in breast cancer. Biochim Biophys Acta 1806: 108-121, 2010.
24. Qiu Z, Huang C, Sun J, et al: RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 98: 1099-2006, 2007.
25. Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schütz A, Kovacic B and Friedrich K: Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9: 279-291, 2007.
26. Chen J, Wang J, Lin L, et al: Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther 11: 277-287, 2012.
27. Wang XH, Liu BR, Qu B, et al: Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. Neoplasma 58: 158-171, 2011.
28. Ding Y, Boguslawski EA, Berghuis BD, et al: Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. Mol Cancer Ther 7: 648-658, 2008.
29. Zhang YH, Wei W, Xu H, Wang YY and Wu WX: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. Chin Med J (Engl) 120: 743-748, 2007.
30. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY and Meldrum DR: STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol 42: 1009-1015, 2007.
31. Yu P, Passam FH, Yu DM, Denyer G and Krilis SA: Beta2-Glycoprotein I inhibits vascular endothelial growth factor and basic fibroblast growth factor induced angiogenesis through its amino terminal domain. J Thromb Haemost 6: 1215-1223, 2008.
32. Hara T, Miyazaki H, Lee A, Tran CP and Reiter RE: Androgen receptor and invasion in prostate cancer. Cancer Res 68: 1128-1135, 2008.
33. Chen JS, Huang XH, Wang Q, et al: Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. Carcinogenesis 34: 10-19, 2013.
34. Segarra M, Ohnuki H, Maric D, et al: Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood 120: 4104-4115, 2012.