Mutational analysis of WTX gene in Wnt/ β-catenin pathway in gastric, colorectal, and hepatocellular carcinomas

Digestive Diseases and Sciences

Volumn 54, Issue 5, 2009, Pages 1011-1014

  Yoo, Nam J ^a   Kim, S ^a   Lee, Sug H ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Colorectal carcinomas; Gastric carcinomas; Hepatocellular carcinomas; Mutation; WTX

Indexed keywords

BETA CATENIN; WNT PROTEIN;

ARTICLE; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NEPHROBLASTOMA; POINT MUTATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TISSUE SECTION; TUMOR GENE; WILMS TUMOR GENE ON THE X CHROMOSOME GENE;

ADENOCARCINOMA; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MUTATION, MISSENSE; POINT MUTATION; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS;

EID: 63949087342     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0458-9     Document Type: Article

References (17)

1. MN Rivera WJ Kim J Wells DR Driscoll BW Brannigan M Han 2007 An X chromosome gene, WTX, is commonly inactivated in Wilms' tumor Science 315 642 645
2. MB Major ND Camp JD Berndt X Yi SJ Goldenberg C Hubbert 2007 Wilms' tumor suppressor WTX negatively regulates WNT/beta-catenin signaling Science 316 1043 1046
3. R Koesters R Ridder A Kopp-Schneider D Betts V Adams F Niggli 1999 Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors Cancer Res 59 3880 3882
4. R Koesters F Niggli M von Knebel Doeberitz T Stallmach 2003 Nuclear accumulation of beta-catenin protein in Wilms' tumours J Pathol 199 68 76
5. H Clevers 2006 Wnt/beta-catenin signaling in development and disease Cell 127 469 480
6. LG Van der Flier J Sabates-Bellver I Oving A Haegebarth M De Palo M Anti 2007 The intestinal Wnt/TCF signature Gastroenterology 132 628 632
7. A de La Coste B Romagnolo P Billuart CA Renard MA Buendia O Soubrane 1998 Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas Proc Natl Acad Sci USA 95 8847 8851
8. SH Lee MS Shin WS Park SY Kim HS Kim JY Han 1999 Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer Oncogene 18 3754 3760
9. HS Kim JW Lee YH Soung WS Park SY Kim JH Lee 2003 Inactivating mutations of caspase-8 gene in colorectal carcinomas Gastroenterology 125 708 715
10. CR Boland SN Thibodeau SR Hamilton D Sidransky JR Eshleman RW Burt 1998 A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 58 5248 5257
11. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57 70
12. J Downward 2003 Targeting RAS signalling pathways in cancer therapy Nat Rev Cancer 3 11 22
13. AJ Levine 1997 p53, the cellular gatekeeper for growth and division Cell 88 323 331
14. JG Paez PA Jänne JC Lee S Tracy H Greulich S Gabriel 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500
15. R Kralovics F Passamonti AS Buser SS Teo R Tiedt JR Passweg 2005 A gain-of-function mutation of JAK2 in myeloproliferative disorders N Engl J Med 352 1779 1790
16. JW Lee YH Soung SY Kim SW Nam WS Park JY Lee 2006 Mutational analysis of MYC in common epithelial cancers and acute leukemias APMIS 114 436 439
17. EG Jeong SH Lee NJ Yoo SH Lee 2007 Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers APMIS 115 341 346