MtDNA T8993G mutation-induced F1F0-ATP synthase defect augments mitochondrial dysfunction associated with hypoxia/reoxygenation: The protective role of melatonin

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Huang, Wen Yi ^a,b   Jou, Mei Jie ^a   Tsung, I Peng ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARDIOLIPIN; MELATONIN; MITOCHONDRIAL DNA; NITRIC OXIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; TRYPAN BLUE; CALCIUM; F1F0-ATP SYNTHASE; NEUROPROTECTIVE AGENT; OXYGEN;

APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MTT ASSAY; NARP SYNDROME; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PROTEIN DEFECT; PROTEIN DEPLETION; REOXYGENATION; CELL HYPOXIA; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; TUMOR CELL LINE;

APOPTOSIS; CALCIUM; CARDIOLIPINS; CELL HYPOXIA; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; HUMANS; MELATONIN; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MUTATION; NEUROPROTECTIVE AGENTS; OXYGEN; REACTIVE OXYGEN SPECIES;

EID: 84896702052     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081546     Document Type: Article

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