Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4350-4364

  Neelarapu, Raghupathi ^a,c   Holzle, Denise L ^a,c   Velaparthi, Subash ^a,d   Bai, He ^a   Brunsteiner, Michael ^a,d   Blond, Sylvie Y ^a,b   Petukhov, Pavel A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITÉ PARIS DIDEROT   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 AZIDOPHENYL)ISOXAZOLE 3 CARBOXYLIC ACID (6 HYDROXYCARBAMOYLHEXYL)AMIDE; 5 [4 (3 AZIDO 5 AZIDOMETHYLBENZOYLAMINO)PHENYL]ISOXAZOLE 3 CARBOXYLIC ACID (6 HYDROXYCARBAMOYLHEXYL)AMIDE; [4 [4 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PYRAZOL 1 YLMETHYL]PHENYL]CARBAMIC ACID TERT BUTYLESTER; AZIDE; DIAZIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; ISOXAZOLE; OCTANEDIOIC ACID (1 BENZYL 1H PYRAZOL 4 YL)AMIDE HYDROXYAMIDE; OCTANEDIOIC ACID [1 (3 AZIDO 5 AZIDOMETHYLBENZYL) 1H PYRAZOL 4 YL]AMIDE HYDROXYAMIDE; OCTANEDIOIC ACID [1 (4 AZIDOBENZYL) 1H PYRAZOL 4 YL)AMIDE HYDROXYAMIDE; OCTANEDIOIC ACID [1 (4 NITROBENZYL) 1H PYRAZOL 4 YL)AMIDE HYDROXYAMIDE; OCTANEDIOIC ACID [1 [4 (3 AZIDO 5 AZIDOMETHYLBENZOYLAMINO)BENZYL] 1H PYRAZOL 4 YL]AMIDE HYDROXYAMIDE; PYRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL MEMBRANE PERMEABILITY; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NEUROPROTECTION; PHOTOAFFINITY LABELING;

ANTINEOPLASTIC AGENTS; AZIDES; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; ISOXAZOLES; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; PHOTOAFFINITY LABELS; PROTEIN BINDING; PYRAZOLES; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960182729     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2001025     Document Type: Article

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