Anticancer effect of salidroside on A549 lung cancer cells through inhibition of oxidative stress and phospho-p38 expression

Oncology Letters

Volumn 7, Issue 4, 2014, Pages 1159-1164

  Wang, Jun ^a   Li, Jian Zhe ^a   Lu, Ai Xia ^a   Zhang, Ke Fen ^b   Li, Bao Jiang ^a  

^a The Central Hospital of Taian   (China)

^b Taishan Sanatorium ^*  (China)

Author keywords

Apoptosis; Epithelial mesenchymal transition; Invasion; Lung cancer; Reactive oxygen species; Salidroside

Indexed keywords

3 (4, 5 DIMETHYL 2 THIAZOLYL) 2, 5 DIPHENYLTETRAZOLIUM BROMIDE; ASCORBIC ACID; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; SALIDROSIDE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE PHASE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER; MTT ASSAY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TUMOR INVASION; WESTERN BLOTTING;

EID: 84896694415     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1863     Document Type: Article

References (31)

1. Han SW and Roman J: Targeting apoptotic signaling pathways in human lung cancer. Curr Cancer Drug Targets 10: 566-574, 2010.
2. Azad N, Iyer A, Vallyathan V, Wang L, Castranova V, Stehlik C and Rojanasakul Y: Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation. Ann N Y Acad Sci 1203: 1-6, 2010.
3. Scatena R: Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. Adv Exp Med Biol 942: 287-308, 2012.
4. Hu ML: Dietary polyphenols as antioxidants and anticancer agents: more questions than answers. Chang Gung Med J 34: 449-460, 2011.
5. Di Domenico F, Foppoli C, Coccia R and Perluigi M: Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols. Biochim Biophys Acta 1822: 737-747, 2012.
6. Panossian A and Wagner H: Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res 19: 819-838, 2005.
7. Yu S, Liu M, Gu X and Ding F: Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. Cell Mol Neurobiol 28: 1067-1078, 2008.
8. Wu YL, Piao DM, Han XH and Nan JX: Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol Pharm Bull 31: 1523-1529, 2008.
9. Li HB, Ge YK, Zheng XX and Zhang L: Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 588: 165-169, 2008.
10. Schriner SE, Abrahamyan A, Avanessian A, et al: Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res 43: 836-843, 2009.
11. Hu X, Lin S, Yu D, Qiu S, Zhang X and Mei R: A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol 26: 499-507, 2010.
12. Liu Z, Li X, Simoneau AR, Jafari M and Zi X: Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog 51: 257-267, 2012.
13. Hu X, Zhang X, Qiu S, Yu D and Lin S: Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Commun 398: 62-67, 2010.
14. Carver EA, Jiang R, Lan Y, Oram KF and Gridley T: The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol 21: 8184-8188, 2001.
15. Sato A, Okada M, Shibuya K, et al: Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells. Stem Cell Res 12: 119-131, 2013.
16. Qu ZQ, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ and Chan WY: Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat. PLoS One 7: e29641, 2012.
17. Zhong H, Xin H, Wu LX and Zhu YZ: Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci 114: 399-408, 2010.
18. Tan CB, Gao M, Xu WR, Yang XY, Zhu XM and Du GH: Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride. Biol Pharm Bull 32: 1359-1363, 2009.
19. Jančinová V, Perečko T, Harmatha J, Nosáľ R and Drábiková K: Decreased activity and accelerated apoptosis of neutrophils in the presence of natural polyphenols. Interdiscip Toxicol 5: 59-64, 2012.
20. Park HS, Park KI, Lee DH, et al: Polyphenolic extract isolated from Korean Lonicera japonica Thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 cells: involvements of PI3K/Akt and MAPKs. Food Chem Toxicol 50: 2407-2416, 2012.
21. Castillo-Pichardo L and Dharmawardhane SF: Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr Cancer 64: 1058-1069, 2012.
22. Shang D, Liu Y, Yang P, Chen Y and Tian Y: TGFBI-promoted adhesion, migration and invasion of human renal cell carcfinoma depends on inactivation of von Hippel-Lindau tumor suppressor. Urology 79: 966. e1-e7, 2012.
23. Sun C, Wang Z, Zheng Q and Zhang H: Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells. Phytomedicine 19: 355-363, 2012.
24. Micalizzi DS, Farabaugh SM and Ford HL: Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 15: 117-134, 2010.
25. Yin D, Yao W, Chen S, Hu R and Gao X: Salidroside, the main active compound of Rhodiola plants, inhibits high glucose-induced mesangial cell proliferation. Planta Med 75: 1191-1195, 2009.
26. Ouyang J, Gao Z, Ren Z, Hong D, Qiao H and Chen Y: Synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis. Pharmazie 65: 607-613, 2010.
27. Yang LH, Ho YJ, Lin JF, Yeh CW, Kao SH and Hsu LS: Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities. Mol Med Rep 6: 1126-1132, 2012.
28. Chye SM, Tiong YL, Yip WK, et al: Apoptosis induced by para-phenylenediamine involves formation of ROS and activation of p38 and JNK in chang liver cells. Environ Toxicol 2012 Nov 22 (Epub ahead of print).
29. Giovannini C and Masella R: Role of polyphenols in cell death control. Nutr Neurosci 15: 134-149, 2012.
30. del Barco Barrantes I and Nebreda AR: Roles of p38 MAPKs in invasion and metastasis. Biochem Soc Trans 40: 79-84, 2012.
31. Lv ZM, Wang Q, Wan Q, Lin JG, Hu MS, Liu YX and Wang R: The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells. PLoS One 6: e22806, 2011.