Salidroside, the main active compound of rhodiola plants, inhibits high glucose-induced mesangial cell proliferation

Planta Medica

Volumn 75, Issue 11, 2009, Pages 1191-1195

  Yin, Dengke ^a,b   Yao, Wenbing ^a   Chen, Song ^a   Hu, Rongfeng ^b   Gao, Xiangdong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

ERK1 2; High glucose; Proliferation; Rhodiola (crassulaceae); Salidroside; TGF 1

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; SALIDROSIDE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MESANGIUM CELL; PROTEIN EXPRESSION; RHODIOLA;

CELL LINE; CELL PROLIFERATION; GLUCOSE; GLUCOSIDES; HUMANS; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHENOLS; PHOSPHORYLATION; RHODIOLA; TRANSFORMING GROWTH FACTOR BETA1;

CRASSULACEAE; RHODIOLA;

EID: 70350769099     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185717     Document Type: Article

References (23)

1. Yamagishi S, Fukami K, Ueda S, Okuda S. Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. Curr Drug Targets 2007; 8: 952-959
2. Mahadevan P, Larkins RG, Fraser JR, Dunlop ME. Effect of prostaglandin E2 and hyaluronan on mesangial cell proliferation. A potential contribution to glomerular hypercellularity in diabetes. Diabetes 1996; 45: 44-50
3. Young BA, Johnson RL, Alpers CE, Eng E, Gordon K, Floege J, Couser WG, Seidel K. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995; 47: 935-944
4. Kurogi Y. Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. Med Res Rev 2003; 23: 15-31
5. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh F N. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int 1992; 42: 647-656
6. Kreisberg JI, Radnik RA, Ayo SH, Garoni J, Saikumar P. High glucose elevates c-fos and c-jun transcripts and proteins inmesangial cell cultures. Kidney Int 1994; 46: 105-112
7. Shankland SJ, Scholey JW. Expression of growth-related protooncogenes during diabetic renal hypertrophy. Kidney Int 1995; 47: 782-788
8. Wolf G, Schroeder R, Ziyadeh FN, Thaiss F, Zahner G, Stahl RA. High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy. Am J Physiol 1997; 273: 348-356
9. Choi HT, Cui CB, Kim SH, Ham YA, Lee DS, Ham SS. Effects of Rhodiola sachalinensis extract in streptozotocin-induced diabetic rats. East Asian Soc Dietary Life 2005; 15: 158-164
10. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006; 26: 209-219
11. Kucinskaite A, Poblocka-Olech L, Krauze-Baranowska M, Sznitowska M, Savickas A, Briedise V. Evaluation of biologically active compounds in roots and rhizomes of Rhodiola rosea L. cultivated in Lithuania. Medcina 2007; 43: 487-494
12. Nakamura S, Li X, Matsuda H, Ninomiya K, Morikawa T, Yamaguti K, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis. Chem Pharm Bull 2007; 55: 1505-1511
13. Li HB, Ge Y, Zheng XX, Zhang L. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 2008; 588: 165-169
14. Ruan XZ, Varghese Z, Powis SH, Moorhead JF. Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation. Kidney Int 2001; 60: 1716-1725
15. Sraer JD, Delarue F, Hagege J, Feunteun J, Pinet F, Nguyen G, Rondeau E. Stable cell lines of T-SV40 immortalized human glomerular mesangial cell. Kidney Int 1996; 49: 267-270
16. Nahman Jr NS, Leonhart KL, Cosio FG, Hebert CL. Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int 1992; 41: 396-402
17. Mason RM, Wahab NA. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 2003; 14: 1358-1373
18. Wolf G, Shankland SJ. Cell cycle control in glomerular disease. Prog Cell Cycle Res 2003; 5: 71-79
19. Rosen LB, Ginty DD, Greenberg ME. Calcium regulation of gene expression. Adv Second Messenger Phosphoprotein Res 1995; 30: 225-253
20. Ziyadeh FN. Mediators of diabetic renal disease: the case for TGF-beta as the major mediator. J Am Soc Nephrol 2004; 15: S55-S57
21. Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in streptozotocin-induced diabetic mice. Diabetes 1996; 45: 522-530
22. Kolm V, Sauer U, Olegomoller B, Scheicher ED. High-glucose-induced TGF-β1 regulates mesangial production of heparan sulfate proteoglycan. Am J Physiol 1996; 270: F812-F821
23. Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Eversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun 2003; 300: 16-22