Salidroside attenuates apoptosis in ischemic cardiomyocytes: A mechanism through a mitochondria-dependent pathway

Journal of Pharmacological Sciences

Volumn 114, Issue 4, 2010, Pages 399-408

  Zhong, Han ^a   Xin, Hong ^a   Wu, Li Xin ^a   Zhu, Yi N ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocyte; Ischemia; Reactive oxygen species; Salidroside

Indexed keywords

CASPASE 3; LOSARTAN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SALIDROSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 79951604453     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10078FP     Document Type: Article

References (31)

1. Zweier JL, Talukder MAH. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res. 2006;70:181-190.
2. Veinot JP, Gattinger DA, Fliss H. Early apoptosis in human myocardial infarcts. Hum Pathol. 1997;28:485-492. (Pubitemid 27175091)
3. Freude B, Masters TN, Kostin S, Robicsek F, Schaper J. Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res Cardiol. 1998;93:85-89.
4. Segers VFM, Lee RT. Stem-cell therapy for cardiac disease. Nature. 2008;451:937-942. (Pubitemid 351301749)
5. Yeh CH, Wang YC, Wu YC, Chu JJ, Lin PJ. Continuous tepid blood cardioplegia can preserve coronary endothelium and ameliorate the occurrence of cardiomyocyte apoptosis. Chest. 2003;123:1647-1654. (Pubitemid 36549788)
6. Saraste A. Morphologic criteria and detection of apoptosis. Herz. 1999;24:189-195. (Pubitemid 29254659)
7. Kumar D, Jugdutt BI. Apoptosis and oxidants in the heart. J Lab Clin Med. 2003;142:288-297. (Pubitemid 37487398)
8. Nohl H, Kozlov AV, Gille L, Staniek K. Cell respiration and formation of reactive oxygen species: facts and artefacts. Biochem Soc Trans. 2003;31:1308-1311. (Pubitemid 38030963)
9. Halliwell B, Aruoma OI. DNA damage by oxygen-derived species - its mechanism and measurement in mammalian systems, FEBS Lett. 1991;281:9-19.
10. Yoshikawa Y, Hizume K, Oda Y, Takeyasu K, Araki S, Yoshikawa K. Protective activity of vitamin C against double-strand breaks in reconstituted chromatin revealed by single-molecule observation. Free Radic Res. 2006;40:S127-S127.
11. Zhu YZ, Huang SH, Tan BKH, Sun J, Whiteman M, Zhu YC. Antioxidants in Chinese herbal medicines: a biochemical perspective. Nat Prod Rep. 2004;21:478-489. (Pubitemid 39187836)
12. Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005;19:819-838. (Pubitemid 41670526)
13. Yu S, Liu M, Gu X, Ding F. Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. Cell Mol Neurobiol. 2008;28:1067-1078.
14. Wang HB, Ding YY, Zhou J, Sun XL, Wang SW. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Phytomedicine. 2009;16:146-155.
15. Wu YL, Piao DM, Han XH, Nan JX. Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol Pharm Bull. 2008;31:1523-1529.
16. Li HB, Ge YK, Zheng XX, Zhang L. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. 2008;588:165-169.
17. Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, et al. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009;43:836-843.
18. Zhang JP, Liu AH, Hou RR, Zhang J, Jia X, Jiang WF, et al. Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1 alpha-activated and VEGF-mediated pathway. Eur J Pharm. 2009;607:6-14.
19. Zhu YZ, Lee HS. Role of angiotensin II receptor antagonists in the treatment of hypertension. Euro J Cardiac Interv. 1999;7:161-166. (Pubitemid 29419703)
20. Chua S, Chang LT, Sun CK, Sheu JJ, Lee FY, Youssef AA, et al. Time courses of subcellular signal transduction and cellular apoptosis in remote viable myocardium of rat left ventricles following acute myocardial infarction: role of pharmacomodulation. J Cardiovasc Pharmacol Ther. 2009;14:104-115.
21. Liu XH, Xin H, Hou AJ, Zhu YZ. Protective effects of leuonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart. Clin Exp Pharmacol Physiol. 2009;36:696-703.
22. Chen HW, Chien CT, Yu SL, Lee YT, Chen WJ. Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70. Br J Pharmacol. 2002;137:771-781.
23. Wilhelm J, Vytasek R, Ostadalova I, Vajner L. Evaluation of different methods detecting intracellular generation of free radicals. Mol Cell Biochem. 2009;328:167-176.
24. Zhuo Y, Chen PF, Zhang AZ, Zhong H, Chen CQ, Zhu YZ. Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of survivin gene. Biol Pharm Bull. 2009;32:1406-1410.
25. Dong CN, Wang Y, Zhu YZ. Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates. Bioorg Med Chem. 2009;17:3499-3507.
26. Ferrari R. The role of mitochondria in ischemic heart disease. J Cardiovasc Pharmacol. 1996;28:S1-S10. (Pubitemid 26314972)
27. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res. 2004;61:461-470. (Pubitemid 38210152)
28. Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood. 1996;88:386-401. (Pubitemid 26240369)
29. Kuwana T, Newmeyer DD. Permeabilisation of mitochondrial outer membrane by Bcl-2 family proteins during apoptosis. Mol Biol Cell. 2002;13:817.
30. Condorelli G, Morisco C, Stassi G, Notte A, Farina F, Sgaramella G, et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. Circulation. 1999;99:3071-3078. (Pubitemid 29270439)
31. Miyamoto S, Murphy AN, Brown JH. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009;41:169-180.