Prefrontal activation deficits during episodic memory in schizophrenia

American Journal of Psychiatry

Volumn 166, Issue 8, 2009, Pages 863-874

  Ragland, John D ^a   Laird, Angela R ^b   Ranganath, Charan ^b   Blumenfeld, Robert S ^b   Gonzales, Sabina M ^b   Glahn, David C ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMNESIA; BRAIN; BRAIN MAPPING; BRAIN SIZE; COGNITION; COGNITIVE DEFECT; EPISODIC MEMORY; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INFORMATION RETRIEVAL; MEMORY DISORDER; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SCHIZOPHRENIA; SUBICULUM; TEMPORAL LOBE; COMPARATIVE STUDY; HEMISPHERIC DOMINANCE; IMAGE PROCESSING; MEDLINE; META ANALYSIS; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SCINTISCANNING; STATISTICS;

BRAIN; BRAIN MAPPING; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MEMORY DISORDERS; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PUBMED; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 68149091629     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2009.08091307     Document Type: Review

References (102)

1. Aleman A, Hijman R, de Haan EHF, Kahn RS: Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry 1999; 156:1358-1366
2. Seidman LJ, Stone WS, Jones R, Harrison RH, Mirsky AF: Comparative effects of schizophrenia and temporal lobe epilepsy on memory. J Int Neuropsychol Soc 1998; 4:342-352 (Pubitemid 28356463)
3. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, Gur RC: Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiatry 1994; 51:124-131 (Pubitemid 24985902)
4. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, Moberg P, Price RA: Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry 1994; 51:651-661 (Pubitemid 24249107)
5. Glahn DC, Almasy L, Blangero J, Burk GM, Estrada J, Peralta JM, Meyenberg N, Castro MP, Barrett J, Nicolini H, Raventos H, Escamilla MA: Adjudicating neurocognitive endophenotypes for schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2007; 144B(2):242-249
6. Goldberg TE, Goldman RS, Burdick KE, Malhotra AK, Lencz T, Patel RC, Woerner MG, Schooler NR, Kane JM, Robinson DG: Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect? Arch Gen Psychiatry 2007; 64:1115-1122
7. Green MF: What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996; 153:321-330
8. Scoville WB, Milner B: Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957; 20:11-21
9. Eichenbaum H, Yonelinas AP, Ranganath C: The medial temporal lobe and recognition memory. Annu Rev Neurosci 2007; 30:123-152 (Pubitemid 47224758)
10. Heckers S: Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 2001; 11:520-528
11. Benes FM, Berretta S: GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001; 25:1-27
12. Gold JM, Randolph C, Carpenter CJ, Goldberg TE, Weinberger DR: Forms of memory failure in schizophrenia. J Abnorm Psychol 1992; 101:487-494
13. Paulsen JS, Heaton RK, Sadek JR, Perry W, Delis DC, Braff D, Kuck J, Zisook S, Jeste DV: The nature of learning and memory impairments in schizophrenia. J Int Neuropsychol Soc 1995; 1:88-99
14. Ranganath C, Knight RT: Prefrontal cortex-related functional neuroimaging, in The Cognitive Neuroscience of Memory Encoding and Retrieval. Edited by Parker A, Wilding EL, Bussey TJ. Philadelphia, Psychology Press, 2003, pp 83-99
15. Iddon JL, McKenna PJ, Sahakian BJ, Robbins TW: Impaired generation and use of strategy in schizophrenia: evidence from visuospatial and verbal tasks. Psychol Med 1998; 28:1049-1062
16. Brebion G, Amador X, Smith MJ, Gorman JM: Mechanisms underlying memory impairment in schizophrenia. Psychol Med 1997; 27:383-393 (Pubitemid 27139971)
17. Ragland JD, Moelter ST, McGrath C, Hill SK, Gur RE, Bilker WB, Siegel SJ, Gur RC: Levels-of-processing effect on word recognition in schizophrenia. Biol Psychiatry 2003; 54:1154-1161 (Pubitemid 37464861)
18. Baare WF, Hulshoff Pol HE, Hijman R, Mali WP, Viergever MA, Kahn RS: Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology. Biol Psychiatry 1999; 45:1597-1605
19. Coyle JT, Tsai G: NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. Int Rev Neurobiol 2004; 59:491-515 (Pubitemid 39752426)
20. Goldman-Rakic PS, Selemon LD: Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull 1997; 23:437-458 (Pubitemid 27427984)
21. Ranganath C, Minzenberg MJ, Ragland JD: The cognitive neuroscience of memory function and dysfunction in schizophrenia. Biol Psychiatry 2008; 64:18-25
22. Achim AM, Lepage M: Episodic memory-related activation in schizophrenia: meta-analysis. Br J Psychiatry 2005; 187:500-509
23. Weiss AP, Heckers S: Neuroimaging of declarative memory in schizophrenia. Scand J Psychol 2001; 42:239-250
24. Turkeltaub P, Eden G, Jones K, Zeffiro T: Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage 2002; 16:765-780 (Pubitemid 34852439)
25. Laird AR, Fox PM, Price CJ, Glahn DC, Uecker AM, Lancaster JL, Turkeltaub PE, Kochunov P, Fox PT: ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts. Hum Brain Mapp 2005; 25:155-164 (Pubitemid 40656201)
26. Achim AM, Bertrand MC, Sutton H, Montoya A, Czechowska Y, Malla AK, Joober R, Pruessner JC, Lepage M: Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis. Arch Gen Psychiatry 2007; 64:999-1014 (Pubitemid 47360845)
27. Bonner-Jackson A, Haut K, Csernansky JG, Barch DM: The influence of encoding strategy on episodic memory and cortical activity in schizophrenia. Biol Psychiatry 2005; 58:47-55 (Pubitemid 40909935)
28. Hazlett EA, Buchsbaum MS, Jeu LA, Nenadic I, Fleischman MB, Shihabuddin L, Haznedar MM, Harvey PD: Hypofrontality in unmedicated schizophrenia patients studied with PET during performance of a serial verbal learning task. Schizophr Res 2000; 43:33-46 (Pubitemid 30316315)
29. Kubicki M, McCarley RW, Nestor PG, Huh T, Kikinis R, Shenton ME, Wible CG: An fMRI study of semantic processing in men with schizophrenia. Neuroimage 2003; 20:1923-1933 (Pubitemid 37543611)
30. Leube DT, Rapp A, Buchkremer G, Bartels M, Kircher TT, Erb M, Grodd W: Hippocampal dysfunction during episodic memory encoding in patients with schizophrenia: an fMRI study. Schizophr Res 2003; 64:83-85 (Pubitemid 37153353)
31. Nohara S, Suzuki M, Kurachi M, Yamashita I, Matsui M, Seto H, Saitoh O: Neural correlates of memory organization deficits in schizophrenia: a single photon emission computed tomography study with 99mTc-ethyl-cysteinate dimer during a verbal learning task. Schizophr Res 2000; 42:209-222 (Pubitemid 30216532)
32. Zorilla LT, Jeste DV, Brown GG: Functional MRI and novel picture-learning among older patients with chronic schizophrenia: abnormal correlations between recognition memory and medial temporal brain response. Am J Geriatr Psychiatry 2002; 10:52-61
33. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Ponto LL, Watkins GL, Hichwa RD: Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Natl Acad Sci USA 1996; 93:9985-9990 (Pubitemid 26296722)
34. Assaf M, Calhoun VD, Kuzu CH, Kraut MA, Rivkin PR, Hart J Jr, Pearlson GD: Neural correlates of the object-recall process in semantic memory. Psychiatry Res 2006; 147:115-126 (Pubitemid 44397460)
35. Assaf M, Rivkin PR, Kuzu CH, Calhoun VD, Kraut MA, Groth KM, Yassa MA, Hart J Jr, Pearlson GD: Abnormal object recall and anterior cingulate overactivation correlate with formal thought disorder in schizophrenia. Biol Psychiatry 2006; 59:452-459 (Pubitemid 43289226)
36. Cairo TA, Woodward TS, Ngan ET: Decreased encoding efficiency in schizophrenia. Biol Psychiatry 2006; 59:740-746
37. Crespo-Facorro B, Paradiso S, Andreasen NC, O'Leary DS, Watkins GL, Boles Ponto LL, Hichwa RD: Recalling word lists reveals "cognitive dysmetria" in schizophrenia: a positron emission tomography study. Am J Psychiatry 1999; 156:386-392
38. Crespo-Facorro B, Wiser AK, Andreasen NC, O'Leary DS, Watkins GL, Boles Ponto LL, Hichwa RD: Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography study. Hum Brain Mapp 2001; 12:219-231 (Pubitemid 32238559)
39. Fletcher P: The missing link: a failure of fronto-hippocampal integration in schizophrenia. Nat Neurosci 1998; 1:266-267
40. Ganguli R, Carter C, Mintun M, Brar J, Becker J, Sarma R, Nichols T, Bennington E: PET brain mapping study of auditory verbal supraspan memory versus visual fixation in schizophrenia. Biol Psychiatry 1997; 41:33-42 (Pubitemid 27050643)
41. Heckers S, Rauch SL, Goff D, Savage CR, Schacter DL, Fischman AJ, Alpert NM: Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat Neurosci 1998; 1:318-323 (Pubitemid 128652679)
42. Heckers S, Goff D, Schacter DL, Savage CR, Fischman AJ, Alpert NM, Rauch SL: Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia. Arch Gen Psychiatry 1999; 56:1117-1123
43. Heckers S, Curran T, Goff D, Rauch SL, Fischman AJ, Alpert NM, Schacter DL: Abnormalities in the thalamus and prefrontal cortex during episodic object recognition in schizophrenia. Biol Psychiatry 2000; 48:651-657 (Pubitemid 30734233)
44. Heinze S, Sartory G, Muller BW, de Greiff A, Forsting M, Juptner M: Neural activation during successful and unsuccessful verbal learning in schizophrenia. Schizophr Res 2006; 83:121-130
45. Jessen F, Scheef L, Germeshausen L, Tawo Y, Kockler M, Kuhn K-U, Maier W, Schild HH, Heun R: Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients. Am J Psychiatry 2003; 160:1305-1312 (Pubitemid 41070948)
46. Lahti AC, Holcomb HH, Medoff DR, Weiler MA, Tamminga CA, Carpenter WT Jr: Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. Am J Psychiatry 2001; 158:1797-1808
47. Ongür D, Cullen TJ, Wolf DH, Rohan M, Barreira P, Zalesak M, Heckers S: The neural basis of relational memory deficits in schizophrenia. Arch Gen Psychiatry 2006; 63:356-365
48. Ragland JD, Gur RC, Glahn DC, Censits DM, Smith RJ, Lazarev MG, Alavi A, Gur RE: Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology 1998; 12:399-413 (Pubitemid 28323860)
49. Ragland JD, McCarthy E, Bilker WB, Brensinger CM, Valdez J, Kohler C, Gur RE, Gur RC: Levels-of-processing effect on internal source monitoring in schizophrenia. Psychol Med 2006; 36:641-648
50. Weiss AP, Schacter DL, Goff DC, Rauch SL, Alpert NM, Fischman AJ, Heckers S: Impaired hippocampal recruitment during normal modulation of memory performance in schizophrenia. Biol Psychiatry 2003; 53:48-55 (Pubitemid 36050935)
51. Weiss AP, Zalesak M, DeWitt I, Goff D, Kunkel L, Heckers S: Impaired hippocampal function during the detection of novel words in schizophrenia. Biol Psychiatry 2004; 55:668-675 (Pubitemid 38376177)
52. Weiss AP, Goff D, Schacter DL, Ditman T, Freudenreich O, Henderson D, Heckers S: Fronto-hippocampal function during temporal context monitoring in schizophrenia. Biol Psychiatry 2006; 60:1268-1277 (Pubitemid 44693542)
53. Wiser AK, Andreasen NC, O'Leary DS, Watkins GL, Boles Ponto LL, Hichwa RD: Dysfunctional cortico-cerebellar circuits cause "cognitive dysmetria" in schizophrenia. Neuroreport 1998; 9:1895-1899
54. Barch DM, Csernansky JG, Conturo T, Snyder AZ: Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism? J Abnorm Psychol 2002; 111:478-494
55. Fahim C, Stip E, Mancini-Marie A, Beauregard M: Genes and memory: the neuroanatomical correlates of emotional memory in monozygotic twin discordant for schizophrenia. Brain Cogn 2004; 55:250-253 (Pubitemid 38726007)
56. Hofer A, Weiss EM, Golaszewski SM, Siedentopf CM, Brinkhoff C, Kremser C, Felber S, Fleischhacker WW: An FMRI study of episodic encoding and recognition of words in patients with schizophrenia in remission. Am J Psychiatry 2003; 160:911-918 (Pubitemid 41079576)
57. Hofer A, Weiss EM, Golaszewski SM, Siedentopf CM, Brinkhoff C, Kremser C, Felber S, Fleischhacker WW: Neural correlates of episodic encoding and recognition of words in unmedicated patients during an acute episode of schizophrenia: a functional MRI study. Am J Psychiatry 2003; 160:1802-1808 (Pubitemid 41103314)
58. Lepage M, Montoya A, Pelletier M, Achim AM, Menear M, Lal S: Associative memory encoding and recognition in schizophrenia: an event-related fMRI study. Biol Psychiatry 2006; 60:1215-1223 (Pubitemid 44693531)
59. Ragland JD, Gur RC, Raz J, Schroeder L, Kohler CG, Smith RJ, Alavi A, Gur RE: Effect of schizophrenia on frontotemporal activity during word encoding and recognition: a PET cerebral blood flow study. Am J Psychiatry 2001; 158:1114-1125 (Pubitemid 32623116)
60. Ragland JD, Gur RC, Valdez J, Turetsky BI, Elliott M, Kohler C, Siegel S, Kanes S, Gur RE: Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia. Am J Psychiatry 2004; 161:1004-1015 (Pubitemid 38735986)
61. Ragland JD, Gur RC, Valdez JN, Loughead J, Elliott M, Kohler C, Kanes S, Siegel SJ, Moelter ST, Gur RE: Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition. Am J Psychiatry 2005; 162:1840-1848 (Pubitemid 41428613)
62. Lancaster JL, Tordesillas-Gutierrez D, Martinez M, Salinas F, Evans A, Zilles K, Mazziotta JC, Fox PT: Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Hum Brain Mapp 2007; 28:1194-1205 (Pubitemid 350077483)
63. Brett M, Leff AP, Rorden C, Ashburner J: Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 2001; 14:486-500 (Pubitemid 32709562)
64. Fox PT, Lancaster JL: Opinion: mapping context and content: the BrainMap model. Nat Rev Neurosci 2002; 3:319-321
65. Laird AR, McMillan KM, Lancaster JL, Kochunov P, Turkeltaub PE, Pardo JV, Fox PT: A comparison of label-based review and ALE meta-analysis in the Stroop task. Hum Brain Mapp 2005; 25:6-21 (Pubitemid 40656189)
66. Laird AR, Lancaster JL, Fox PT: BrainMap: the social evolution of a human brain mapping database. Neuroinformatics 2005; 3:65-78
67. Barch DM, Carter CS, Braver TS, Sabb FW, MacDonald A 3rd, Noll DC, Cohen JD: Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry 2001; 58:280-288
68. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR: Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry 2003; 160:2209-2215 (Pubitemid 39619615)
69. MacDonald AW III, Carter CS, Kerns JG, Ursu S, Barch DM, Holmes AJ, Stenger VA, Cohen JD: Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am J Psychiatry 2005; 162:475-484 (Pubitemid 40343914)
70. Tan H-Y, Sust S, Buckholtz JW, Mattay VS, Meyer-Lindenberg A, Egan MF, Weinberger DR, Callicott JH: Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry 2006; 163:1969-1977 (Pubitemid 44807789)
71. Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, Velligan DI: Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp 2005; 25:60-69 (Pubitemid 40656193)
72. Tan HY, Callicott JH, Weinberger DR: Dysfunctional and compensatory prefrontal cortical systems, genes, and the pathogenesis of schizophrenia. Cereb Cortex 2007; 17(suppl 1):i171-i181
73. Wolf DH, Gur RC, Valdez JN, Loughead J, Elliott MA, Gur RE, Ragland JD: Alterations of fronto-temporal connectivity during word encoding in schizophrenia. Psychiatr Res 2007; 154:221-232 (Pubitemid 46428528)
74. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL: A default mode of brain function. Proc Natl Acad Sci USA 2001; 98:676-682
75. Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ: Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 2009; 33:279-296
76. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD: Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry 2007; 164:450-457
77. Braver TS, Bongiolatti SR: The role of frontopolar cortex in subgoal processing during working memory. Neuroimage 2002; 15:523-536 (Pubitemid 34852520)
78. Fletcher PC, Henson RN: Frontal lobes and human memory: insights from functional neuroimaging. Brain 2001; 124:849-881 (Pubitemid 32458500)
79. Kan IP, Thompson-Schill SL: Selection from perceptual and conceptual representations. Cogn Affect Behav Neurosci 2004; 4:466-482
80. Blumenfeld RS, Ranganath C: Prefrontal cortex and long-term memory encoding: an integrative review of findings from neuropsychology and neuroimaging. Neuroscientist 2007; 13:280-291
81. Barch DM, Braver TS, Nystrom LE, Forman SD, Noll DC, Cohen JD: Dissociating working memory from task difficulty in human prefrontal cortex. Neuropsychologia 1997; 35:1373-1380 (Pubitemid 27455564)
82. Blumenfeld RS, Ranganath C: Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization. J Neurosci 2006; 26:916-925
83. Murray LJ, Ranganath C: The dorsolateral prefrontal cortex contributes to successful relational memory encoding. J Neurosci 2007; 27:5515-5522 (Pubitemid 46790175)
84. Achim AM, Lepage M: Neural correlates of memory for items and for associations: an event-related functional magnetic resonance imaging study. J Cogn Neurosci 2005; 17:652-667 (Pubitemid 40478287)
85. Rugg MD, Henson RN, Robb WG: Neural correlates of retrieval processing in the prefrontal cortex during recognition and exclusion tasks. Neuropsychologia 2003; 41:40-52
86. Carter CS, van Veen V: Anterior cingulate cortex and conflict detection: an update of theory and data. Cogn Affect Behav Neurosci 2007; 7:367-379
87. Andrews J, Wang L, Csernansky JG, Gado MH, Barch DM: Abnormalities of thalamic activation and cognition in schizophrenia. Am J Psychiatry 2006; 163:463-469 (Pubitemid 44469389)
88. Segarra N, Bernardo M, Valdes M, Caldu X, Falcon C, Rami L, Bargallo N, Parramon G, Junque C: Cerebellar deficits in schizophrenia are associated with executive dysfunction. Neuroreport 2008; 19:1513-1517
89. Shallice T: From Neuropsychology to Mental Structure. Cambridge, UK, Cambridge University Press, 1988
90. Cohen JD, Servan-Schreiber D: Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol Rev 1992; 99:45-77
91. Jones EG: The Thalamus. New York, Plenum Press, 1985
92. Carter CS, Barch DM: Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative. Schizophr Bull 2007; 33:1131-1137
93. Ramsey NF, Jansma JM, Jager G, Van Raalten T, Kahn RS: Neurophysiological factors in human information processing capacity. Brain 2004; 127:517-525 (Pubitemid 38295469)
94. Johansen-Berg H: Structural plasticity: rewiring the brain. Curr Biol 2007; 17(4):R141-R144
95. Achim AM, Lepage M: Is associative recognition more impaired than item recognition memory in schizophrenia? a meta-analysis. Brain Cogn 2003; 53:121-124
96. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA: Remembering episodes: a selective role for the hippocampus during retrieval. Nat Neurosci 2000; 3:1149-1152
97. Hannula DE, Tranel D, Cohen NJ: The long and the short of it: relational memory impairments in amnesia, even at short lags. J Neurosci 2006; 26:8352-8359 (Pubitemid 44309849)
98. Snitz BE, MacDonald A III, Cohen JD, Cho RY, Becker T, Carter CS: Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. Am J Psychiatry 2005; 162:2322-2329 (Pubitemid 41740211)
99. Davidson PS, Troyer AK, Moscovitch M: Frontal lobe contributions to recognition and recall: linking basic research with clinical evaluation and remediation. J Int Neuropsychol Soc 2006; 12(2):210-223
100. Stein EA: fMRI: a new tool for the in vivo localization of drug actions in the brain. J Anal Toxicol 2001; 29:419-424 (Pubitemid 32656297)
101. Honey G, Bullmore E: Human pharmacological MRI. Trends Pharmacol Sci 2004; 25:366-374
102. Gray JA, Roth BL: Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull 2007; 33:1100-1119 (Pubitemid 47347917)