Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis

Acta Neuropathologica

Volumn 127, Issue 4, 2014, Pages 573-591

  Brosius, Stephanie N ^a,b   Turk, Amy N ^a   Byer, Stephanie J ^a   Brossier, Nicole M ^a,b   Kohli, Latika ^a   Whitmire, Amber ^a   Mikhail, Fady M ^c   Roth, Kevin A ^a   Carroll, Steven L ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

erbB receptors; Genetic complementation; Mouse models; Neurofibromatosis; Sarcoma

Indexed keywords

CALPONIN; DESMIN; NESTIN; NEU DIFFERENTIATION FACTOR; PROTEIN P53; PROTEIN S100B; RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL ADHESION; CELL DIFFERENTIATION; CHROMOSOME 10; CHROMOSOME 14; CHROMOSOME 7; CHROMOSOME ARM; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DORSAL ROOT; EXON; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE DOSAGE; GENE OVEREXPRESSION; GENETIC COMPLEMENTATION; GENOTYPE; HAPLOINSUFFICIENCY; IMMUNOBLOTTING; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; KRINGLE DOMAIN; MALE; MALIGNANT PERIPHERAL NERVE SHEATH TUMOR; MITOSIS RATE; MOUSE; NEUROFIBROMA; NONHUMAN; PRIORITY JOURNAL; SCHWANN CELL CULTURE; SIGNAL TRANSDUCTION; TRANSGENE; TRIGEMINAL NERVE; TUMOR NECROSIS;

ANIMALS; DESMIN; GENE EXPRESSION; HAPLOINSUFFICIENCY; HUMANS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; MYELIN P0 PROTEIN; NEUREGULIN-1; NEUROFIBROMA; OPTIC NERVE NEOPLASMS; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SPINAL CORD; SPINAL NERVE ROOTS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896543356     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1209-3     Document Type: Article

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