Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells

Cancer Cell

Volumn 13, Issue 2, 2008, Pages 105-116

  Wu, Jianqiang ^a   Williams, Jon P ^a   Rizvi, Tilat A ^a   Kordich, Jennifer J ^a   Witte, David ^a   Meijer, Dies ^c   Stemmer Rachamimov, Anat O ^b   Cancelas, Jose A ^a   Ratner, Nancy ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

CELLCYCLE; STEMCELL

Indexed keywords

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; COLONY FORMING UNIT; CONTROLLED STUDY; DESERT HEDGEHOG CRE RECOMBINASE GENE; GENE; GENE MUTATION; GLIA CELL; MOUSE; NEURAL CREST; NEURINOMA; NEUROFIBROMA; NEUROFIBROMATOSIS TYPE 1 GENE; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; SCHWANN CELL;

ERINACEIDAE;

EID: 38549108007     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2007.12.027     Document Type: Article

References (50)

1. Aquino J., Hjerling-Leffler J., Koltzenburg M., Villar M., and Ernfors P. In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells. Exp. Neurol. 198 (2006) 438-449
2. Asbury A. Schwann cell proliferation in developing mouse sciatic nerve. A radioautographic study. J. Cell Biol. 34 (1967) 735-743
3. Bitgood M., and McMahon A. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172 (1995) 126-138
4. Brannan C., Perkins A., Vogel K., Ratner N., Nordlund M., Reid S., Buchberg A., Jenkins N., Parada L., and Copeland N. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8 (1994) 1019-1029
5. Cichowski K., and Jacks T. NF1 tumor suppressor function: Narrowing the GAP. Cell 104 (2001) 593-604
6. Cichowski K., Santiago S., Jardim M., Johnson B., and Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 17 (2003) 449-454
7. Cichowski K., Shih T.S., Schmitt E., Santiago S., Reilly K., McLaughlin M.E., Bronson R.T., and Jacks T. Mouse models of tumor development in neurofibromatosis type 1. Science 286 (1999) 2172-2176
8. Courtois-Cox S., Genther Williams S., Reczek E., Johnson B., McGillicuddy L., Johannessen C., Hollstein P., MacCollin M., and Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10 (2006) 459-472
9. ras contributes to malignant tumor growth in von Recklinghausen (Type 1) neurofibromatosis. Cell 69 (1992) 265-273
10. Dickersin G. The electron microscopic spectrum of nerve sheath tumors. Ultrastruct. Pathol. 11 (1987) 103-146
11. Feigenbaum L., Fujita K., Collins F., and Jay G. Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice. J. Virol. 70 (1996) 3280-3285
12. Fernandes K., McKenzie I., Mill P., Smith K., Akhavan M., Barnabé-Heider F., Biernaskie J., Junek A., Kobayashi N., Toma J., et al. A dermal niche for multipotent adult skin-derived precursor cells. Nat. Cell Biol. 6 (2004) 1082-1093
13. Friedman J. Epidemiology of neurofibromatosis type 1. Am. J. Med. Genet. 89 (1999) 1-6
14. Gitler A., Zhu Y., Ismat F., Lu M., Yamauchi Y., Parada L., and Epstein J.A. Nf1 has an essential role in endothelial cells. Nat. Genet. 33 (2003) 75-79
15. Guha A., Lau N., Huvar I., Gutman D., Provias J., Pawson T., and Boss G. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene 12 (1996) 507-513
16. Huson S. Neurofibromatosis type 1: Historical perspective and introductory overview. In: In Upadhyaya M., and Cooper D.N. (Eds). Neurofibromatosis Type 1: From Genotype to Phenotype (1998), BIOS Scientific Publishers Ltd., Oxford, U.K. 1-13
17. Jacks T., Shih T.S., Schmitt E.M., Bronson R.T., Bernards A., and Weinberg R.A. Tumor predisposition in mice heterozygous for a targeted mutation in NF1. Nat. Genet. 7 (1994) 353-361
18. Jaegle M., Ghazvini M., Mandemakers W., Piirsoo M., Driegen S., Levavasseur F., Raghoenath S., Grosveld F., and Meijer D. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev. 17 (2003) 1380-1391
19. Jessen K., and Mirsky R. The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 6 (2005) 671-682
20. Jippo T., Morii E., Tsujino K., Tsujimura T., Lee Y., Kim D., Matsuda H., Kim H., and Kitamura Y. Involvement of transcription factor encoded by the mouse mi locus (MITF) in expression of p75 receptor of nerve growth factor in cultured mast cells of mice. Blood 90 (1997) 2601-2608
21. Joseph N., Mukouyama Y., Mosher J., Jaegle M., Crone S., Dormand E., Lee K., Meijer D., Anderson D., and Morrison S. Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development 131 (2004) 5599-5612
22. Kim H.A., Ling B., and Ratner N. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: Reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Mol. Cell. Biol. 17 (1997) 862-872
23. ras, inhibition of cell proliferation and morphological changes. Oncogene 11 (1995) 325-335
24. Le Douarin N., and Dupin E. Multipotentiality of the neural crest. Curr. Opin. Genet. Dev. 13 (2003) 529-536
25. Ling B., Wu J., Miller S., Monk K., Shamekh R., Rizvi T., Decourten-Myers G., Vogel K., DeClue J., and Ratner N. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7 (2005) 65-75
26. Maertens O., De Schepper S., Vandesompele J., Brems H., Heyns I., Janssens S., Speleman F., Legius E., and Messiaen L. Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1. Am. J. Hum. Genet. 81 (2007) 243-251
27. Maro G., Vermeren M., Voiculescu O., Melton L., Cohen J., Charnay P., and Topilko P. Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat. Neurosci. 7 (2004) 930-938
28. Morrison S., White P., Zock C., and Anderson D. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 96 (1999) 737-749
29. Nakamura T., Colbert M., and Robbins J. Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ. Res. 98 (2006) 1547-1554
30. Obata K., Katsura H., Sakurai J., Kobayashi K., Yamanaka H., Dai Y., Fukuoka T., and Noguchi K. Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury. J. Neurosci. 26 (2006) 11974-11986
31. Parmantier E., Lynn B., Lawson D., Turmaine M., Namini S., Chakrabarti L., McMahon A., Jessen K., and Mirsky R. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron 23 (1999) 713-724
32. Ratner N., Williams J.P., Kordich J.J., and Kim H.A. Schwann cell preparation from single mouse embryos: Analyses of neurofibromin function in Schwann cells. Methods Enzymol. 407 (2005) 22-33
33. Rizvi T., Huang Y., Sidani A., Atit R., Largaespada D., Boissy R., and Ratner N. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. J. Neurosci. 22 (2002) 9831-9840
34. Ryan J., Klein K., Neuberger T., Leftwich J., Westin E., Kauma S., Fletcher J., DeVries G., and Huff T. Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosis. J. Neurosci. Res. 37 (1994) 415-432
35. Saito H., Yoshida T., Yamazaki H., and Suzuki N. Conditional N-rasG12V expression promotes manifestations of neurofibromatosis in a mouse model. Oncogene 26 (2007) 4714-4719
36. Serra E., Puig S., Otero D., Gaona A., Kruyer H., Ars E., Estivill X., and Lazaro C. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. Am. J. Hum. Genet. 61 (1997) 512-519
37. Sheela S., Riccardi V., and Ratner N. Angiogenic and invasive properties of neurofibroma Schwann cells. J. Cell Biol. 111 (1990) 645-653
38. Sherman L., Atit R., Rosenbaum T., Cox A., and Ratner N. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. J. Biol. Chem. 275 (2000) 30740-30745
39. Sieber-Blum M., Grim M., Hu Y., and Szeder V. Pluripotent neural crest stem cells in the adult hair follicle. Dev. Dyn. 231 (2004) 258-269
40. Stemmer-Rachamimov A., Louis D., Nielsen G., Antonescu C., Borowsky A., Bronson R., Burns D., Cervera P., McLaughlin M., Reifenberger G., et al. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res. 64 (2004) 3718-3724
41. Stemple D., and Anderson D. Lineage diversification of the neural crest: In vitro investigations. Dev. Biol. 159 (1993) 12-23
42. Vogel K.S., Klesse L.J., Velasco-Miguel S., Meyers K., Rushing E.J., and Parada L.F. Mouse tumor model for neurofibromatosis type 1. Science 286 (1999) 2176-2179
43. White P., and Anderson D. In vivo transplantation of mammalian neural crest cells into chick hosts reveals a new autonomic sublineage restriction. Development 126 (1999) 4351-4363
44. White P., Morrison S., Orimoto K., Kubu C., Verdi J., and Anderson D. Neural crest stem cells undergo cell-intrinsic developmental changes in sensitivity to instructive differentiation signals. Neuron 29 (2001) 57-71
45. Williams S., Mear J., Liang H., Potter S., Aronow B., and Colbert M. Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure. Physiol. Genomics 19 (2004) 184-197
46. Wong C., Paratore C., Dours-Zimmermann M., Rochat A., Pietri T., Suter U., Zimmermann D., Dufour S., Thiery J., Meijer D., et al. Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J. Cell Biol. 175 (2006) 1005-1015
47. Wu J., Crimmins J., Monk K., Williams J., Fitzgerald M., Tedesco S., and Ratner N. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am. J. Pathol. 168 (2006) 1686-1696
48. Yang F., Ingram D., Chen S., Hingtgen C., Ratner N., Monk K., Clegg T., White H., Mead L., Wenning M., et al. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J. Clin. Invest. 112 (2003) 1851-1861
49. Zhu Y., Ghosh P., Charnay P., Burns D., and Parada L. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296 (2002) 920-922
50. Zorick T., Syroid D., Brown A., Gridley T., and Lemke G. Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. Development 126 (1999) 1397-1406