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Volumn 74, Issue 5, 2014, Pages 1429-1439

Suppression of MicroRNA-9 by Mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MICRORNA 9; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN;

EID: 84896533279     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2117     Document Type: Article
Times cited : (58)

References (50)
  • 3
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci U S A 1990;87:8602-6.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 4
  • 5
    • 0032510679 scopus 로고    scopus 로고
    • Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of bcl-xl and caspase-3-like proteases
    • Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJ. Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A 1998; 95:5724-9.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5724-5729
    • Nagane, M.1    Levitzki, A.2    Gazit, A.3    Cavenee, W.K.4    Huang, H.J.5
  • 6
    • 84862909038 scopus 로고    scopus 로고
    • Guanylate binding protein 1 is a novel effector of egfr-driven invasion in glioblastoma
    • Li M, Mukasa A, IndaMM,Zhang J, Chin L, Cavenee W, et al. Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. J Exp Med 2011;208:2657-73.
    • (2011) J Exp Med , vol.208 , pp. 2657-2673
    • Li, M.1    Mukasa, A.2    Inda, M.M.3    Zhang, J.4    Chin, L.5    Cavenee, W.6
  • 8
    • 77249101567 scopus 로고    scopus 로고
    • Mutant egfr is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence
    • Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F. Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. Proc Natl Acad Sci U S A 2010;107:2616-21.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2616-2621
    • Mukasa, A.1    Wykosky, J.2    Ligon, K.L.3    Chin, L.4    Cavenee, W.K.5    Furnari, F.6
  • 9
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant egfr-induced cytokine circuit in glioblastoma
    • Inda MM,Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010;24: 1731-45.
    • (2010) Genes Dev , vol.24 , pp. 1731-1745
    • Inda, M.M.1    Bonavia, R.2    Mukasa, A.3    Narita, Y.4    Sah, D.W.5    Vandenberg, S.6
  • 11
    • 10644234841 scopus 로고    scopus 로고
    • The drosha-dgcr8 complex in primary microrna processing
    • Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004;18: 3016-27.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Kim, Y.K.4    Jin, H.5    Kim, V.N.6
  • 12
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-micrornas and short hairpin rnas
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003;17: 3011-6.
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 13
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to rna interference regulate expression of the small temporalrnas that control c. Elegans developmental timing
    • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, et al. Genes and mechanisms related to RNA interference regulate expression of the small temporalRNAs that control C. elegans developmental timing. Cell 2001;106:23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6
  • 15
    • 33750370444 scopus 로고    scopus 로고
    • Microrna signatures in human cancers
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66.
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 16
    • 77649275464 scopus 로고    scopus 로고
    • Mir-9, a myc/mycn-Activated microrna, regulates e-cadherin and cancer metastasis
    • Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, et al. miR-9, a MYC/MYCN-Activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010;12:247-56.
    • (2010) Nat Cell Biol , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3    Pan, E.4    Mestdagh, P.5    Muth, D.6
  • 18
    • 45549089973 scopus 로고    scopus 로고
    • Microrna-7 inhibits the epidermal growth factor receptor and the akt pathway and is down-regulated in glioblastoma
    • Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, et al. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008; 68:3566-72.
    • (2008) Cancer Res , vol.68 , pp. 3566-3572
    • Kefas, B.1    Godlewski, J.2    Comeau, L.3    Li, Y.4    Abounader, R.5    Hawkinson, M.6
  • 19
    • 77953498262 scopus 로고    scopus 로고
    • Microrna-34a is tumor suppressive in brain tumors and glioma stem cells
    • Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D, et al. microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 2010;9:1031-6.
    • (2010) Cell Cycle , vol.9 , pp. 1031-1036
    • Guessous, F.1    Zhang, Y.2    Kofman, A.3    Catania, A.4    Li, Y.5    Schiff, D.6
  • 21
    • 0029815093 scopus 로고    scopus 로고
    • Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the ras-shc-grb2 pathway
    • Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, et al. Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem 1996;271:25639-45.
    • (1996) J Biol Chem , vol.271 , pp. 25639-25645
    • Prigent, S.A.1    Nagane, M.2    Lin, H.3    Huvar, I.4    Boss, G.R.5    Feramisco, J.R.6
  • 22
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and ink4a/arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002;1: 269-77.
    • (2002) Cancer Cell , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3    Sharpless, N.E.4    Chan, S.S.5    You, M.J.6
  • 23
    • 69649088804 scopus 로고    scopus 로고
    • Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (nf1)-regulated glial proliferation
    • Yeh TH, Lee da Y, Gianino SM, Gutmann DH. Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation. Glia 2009;57: 1239-49.
    • (2009) Glia , vol.57 , pp. 1239-1249
    • Yeh, T.H.1    Lee Da, Y.2    Gianino, S.M.3    Gutmann, D.H.4
  • 25
    • 65249131826 scopus 로고    scopus 로고
    • Induction and regulatory function of mir-9 in human monocytes and neutrophils exposed to proinflammatory signals
    • Bazzoni F, Rossato M, Fabbri M, Gaudiosi D, Mirolo M, Mori L, et al. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci U S A 2009;106:5282-7.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5282-5287
    • Bazzoni, F.1    Rossato, M.2    Fabbri, M.3    Gaudiosi, D.4    Mirolo, M.5    Mori, L.6
  • 26
    • 0029961912 scopus 로고    scopus 로고
    • A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis
    • Nagane M, Coufal F, Lin H, Bogler O, Cavenee WK, Huang HJ. A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res 1996;56:5079-86.
    • (1996) Cancer Res , vol.56 , pp. 5079-5086
    • Nagane, M.1    Coufal, F.2    Lin, H.3    Bogler, O.4    Cavenee, W.K.5    Huang, H.J.6
  • 27
    • 77953850680 scopus 로고    scopus 로고
    • Egf decreases the abundance of micrornas that restrain oncogenic transcription factors
    • Avraham R, Sas-Chen A, Manor O, Steinfeld I, Shalgi R, Tarcic G, et al. EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors. Sci Signal 2010;3:ra43.
    • (2010) Sci Signal , vol.3
    • Avraham, R.1    Sas-Chen, A.2    Manor, O.3    Steinfeld, I.4    Shalgi, R.5    Tarcic, G.6
  • 28
    • 84868661333 scopus 로고    scopus 로고
    • Current progress on understanding micro-rnas in glioblastoma multiforme
    • Karsy M, Arslan E, Moy F. Current progress on understanding Micro-RNAs in glioblastoma multiforme. Genes Cancer 2012;3:3-15.
    • (2012) Genes Cancer , vol.3 , pp. 3-15
    • Karsy, M.1    Arslan, E.2    Moy, F.3
  • 29
    • 0031961980 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
    • Moscatello DK, Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ. Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 1998;273:200-6.
    • (1998) J Biol Chem , vol.273 , pp. 200-206
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Emlet, D.R.3    Montgomery, R.B.4    Wong, A.J.5
  • 31
    • 11244344906 scopus 로고    scopus 로고
    • Glioma formation in neurofibromatosis 1 reflects preferential activation of k-ras in astrocytes
    • Dasgupta B, Li W, Perry A, Gutmann DH. Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res 2005;65:236-45.
    • (2005) Cancer Res , vol.65 , pp. 236-245
    • Dasgupta, B.1    Li, W.2    Perry, A.3    Gutmann, D.H.4
  • 32
    • 79955501601 scopus 로고    scopus 로고
    • Id4 imparts chemoresistance and cancer stemness to glioma cells by derepressing mir-9-mediated suppression of sox2
    • Jeon HM, Sohn YW, Oh SY, Kim SH, Beck S, Kim S, et al. ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9-mediated suppression of SOX2. Cancer Res 2011;71: 3410-21.
    • (2011) Cancer Res , vol.71 , pp. 3410-3421
    • Jeon, H.M.1    Sohn, Y.W.2    Oh, S.Y.3    Kim, S.H.4    Beck, S.5    Kim, S.6
  • 33
    • 79955514336 scopus 로고    scopus 로고
    • A developmental taxonomy of glioblastoma defined and maintained by micrornas
    • Kim TM, Huang W, Park R, Park PJ, Johnson MD. A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs. Cancer Res 2011;71:3387-99.
    • (2011) Cancer Res , vol.71 , pp. 3387-3399
    • Kim, T.M.1    Huang, W.2    Park, R.3    Park, P.J.4    Johnson, M.D.5
  • 34
    • 78651307694 scopus 로고    scopus 로고
    • Starbase: A database for exploring microrna-mrna interaction maps from argonaute clip-seq and degradome-seq data
    • Yang JH, Li JH, Shao P, Zhou H, Chen YQ, Qu LH. starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res 2011; 39:D202-9.
    • (2011) Nucleic Acids Res , vol.39
    • Yang, J.H.1    Li, J.H.2    Shao, P.3    Zhou, H.4    Chen, Y.Q.5    Qu, L.H.6
  • 35
    • 78751560995 scopus 로고    scopus 로고
    • Microrna mir-9 modifies motor neuron columns by a tuning regulation of foxp1 levels in developing spinal cords
    • Otaegi G, Pollock A, Hong J, Sun T. MicroRNA miR-9 modifies motor neuron columns by a tuning regulation of FoxP1 levels in developing spinal cords. J Neurosci 2011;31:809-18.
    • (2011) J Neurosci , vol.31 , pp. 809-818
    • Otaegi, G.1    Pollock, A.2    Hong, J.3    Sun, T.4
  • 36
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang HS, Nagane M, Klingbeil CK, Lin H, NishikawaR, Ji XD, et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 1997;272:2927-35.
    • (1997) J Biol Chem , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3    Lin, H.4    NishikawaR Ji, X.D.5
  • 37
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in pdgfra, idh1, egfr, and nf1
    • Verhaak RG, Hoadley KA, Purdom E,WangV, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 38
    • 0037637550 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization
    • Schmidt MH, Furnari FB, Cavenee WK, Bogler O. Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci U S A 2003;100:6505-10.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6505-6510
    • Schmidt, M.H.1    Furnari, F.B.2    Cavenee, W.K.3    Bogler, O.4
  • 39
    • 77953565590 scopus 로고    scopus 로고
    • Phosphotyrosine signaling analysis of site-specific mutations on egfrviii identifies determinants governing glioblastoma cell growth
    • Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, Flynn RA, et al. Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth. Mol Biosyst 2010;6:1227-37.
    • (2010) Mol Biosyst , vol.6 , pp. 1227-1237
    • Huang, P.H.1    Miraldi, E.R.2    Xu, A.M.3    Kundukulam, V.A.4    Del Rosario, A.M.5    Flynn, R.A.6
  • 43
    • 80054937128 scopus 로고    scopus 로고
    • Camta1 is a novel tumour suppressor regulated by mir-9/9 in glioblastoma stem cells
    • Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY, et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9 in glioblastoma stem cells. EMBO J 2011;30:4309-22.
    • (2011) EMBO J , vol.30 , pp. 4309-4322
    • Schraivogel, D.1    Weinmann, L.2    Beier, D.3    Tabatabai, G.4    Eichner, A.5    Zhu, J.Y.6
  • 44
    • 80052332283 scopus 로고    scopus 로고
    • Expression of pik3ca and foxp1 in gastric and intestinal non-hodgkin's lymphoma of mucosa-Associated lymphoid tissue type
    • Zhai L, Zhao Y, Ye S, Huang H, Tian Y, Wu Q, et al. Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lymphoma of mucosa-Associated lymphoid tissue type. Tumour Biol 2011;32: 913-20.
    • (2011) Tumour Biol , vol.32 , pp. 913-920
    • Zhai, L.1    Zhao, Y.2    Ye, S.3    Huang, H.4    Tian, Y.5    Wu, Q.6
  • 45
    • 84862805434 scopus 로고    scopus 로고
    • Prognostic significance of foxp1 as an oncogene in hepatocellular carcinoma
    • Zhang Y, Zhang S, Wang X, Liu J, Yang L, He S, et al. Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma. J Clin Pathol 2012;65:528-33.
    • (2012) J Clin Pathol , vol.65 , pp. 528-533
    • Zhang, Y.1    Zhang, S.2    Wang, X.3    Liu, J.4    Yang, L.5    He, S.6
  • 46
    • 84863223625 scopus 로고    scopus 로고
    • Association of double-positive foxa1 and foxp1 immunoreactivities with favorable prognosis of tamoxifen-Treated breast cancer patients
    • Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, et al. Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-Treated breast cancer patients. Horm Cancer 2012;3:147-59.
    • (2012) Horm Cancer , vol.3 , pp. 147-159
    • Ijichi, N.1    Shigekawa, T.2    Ikeda, K.3    Horie-Inoue, K.4    Shimizu, C.5    Saji, S.6
  • 47
    • 84863980960 scopus 로고    scopus 로고
    • Forkhead box p1 overexpression and its clinicopathologic significance in peripheral t-cell lymphoma, not otherwise specified
    • Yamada S, Sato F, Xia H, Takino H, Kominato S, Ri M, et al. Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specified. Hum Pathol 2012; 43:1322-7.
    • (2012) Hum Pathol , vol.43 , pp. 1322-1327
    • Yamada, S.1    Sato, F.2    Xia, H.3    Takino, H.4    Kominato, S.5    Ri, M.6
  • 48
    • 80054051092 scopus 로고    scopus 로고
    • Foxp1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-Treated breast cancer
    • Shigekawa T, Ijichi N, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, et al. FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-Treated breast cancer. Horm Cancer 2011; 2:286-97.
    • (2011) Horm Cancer , vol.2 , pp. 286-297
    • Shigekawa, T.1    Ijichi, N.2    Ikeda, K.3    Horie-Inoue, K.4    Shimizu, C.5    Saji, S.6
  • 49
    • 0037467540 scopus 로고    scopus 로고
    • Characterization of foxp2 and foxp1mrnaand protein in the developing and mature brain
    • Ferland RJ, Cherry TJ, Preware PO, Morrisey EE, Walsh CA. Characterization of Foxp2 and Foxp1mRNAand protein in the developing and mature brain. J Comp Neurol 2003;460:266-79.
    • (2003) J Comp Neurol , vol.460 , pp. 266-279
    • Ferland, R.J.1    Cherry, T.J.2    Preware, P.O.3    Morrisey, E.E.4    Walsh, C.A.5
  • 50


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