Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme

Genes and Cancer

Volumn 3, Issue 1, 2012, Pages 3-15

  Karsy, Michael ^a   Arslan, Erol ^b   Moy, Fred ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b GOZTEPE TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

GBM; glioma; microarray; miR; review

Indexed keywords

BCL2 RELATED PROTEIN A1; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MICRORNA; MICRORNA 101; MICRORNA 124A; MICRORNA 125B; MICRORNA 128; MICRORNA 137; MICRORNA 146B 5P; MICRORNA 153; MICRORNA 15B; MICRORNA 17 92; MICRORNA 181A; MICRORNA 196A; MICRORNA 21; MICRORNA 218; MICRORNA 221; MICRORNA 26A; MICRORNA 29B; MICRORNA 34A; MICRORNA 7; MICRORNA 9; MICRORNA 93; SMALL UNTRANSLATED RNA; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

APOPTOSIS; CANCER INHIBITION; CANCER INVASION; CANCER STEM CELL; CELL DIFFERENTIATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE TARGETING; GLIOBLASTOMA; HUMAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; PRIORITY JOURNAL; REGULATORY RNA SEQUENCE; REVIEW; RNA PROCESSING; RNA TRANSLATION; RNA TRANSPORT; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 84868661333     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601912448068     Document Type: Review

References (90)

1. Ohgaki H,Kleihues P.Genetic alterations and signaling pathways in the evolution of gliomas.Cancer Sci. 2009;100:2235-41.
2. Stupp R,Hegi ME,Mason WP,et al.Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.Lancet Oncol. 2009;10:459-66.
3. Huse JT,Holland EC.Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.Nat Rev Cancer. 2010;10:319-31.
4. Garzon R,Calin GA,Croce CM.MicroRNAs in cancer.Annu Rev Med. 2009;60:167-79.
5. Kozomara A,Griffiths-Jones S.miRBase: integrating microRNA annotation and deep-sequencing data.Nucleic Acids Res. 2011;39:D152-7.
6. Karsy M,Albert L,Tobias ME,et al.All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner.Anticancer Res. 2010;30:4915-20.
7. Liu C,Tang DG.MicroRNA regulation of cancer stem cells.Cancer Res. 2011;71:5950-4.
8. Gulati N,Karsy M,Albert L,et al.Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.Int J Oncol. 2009;35:731-40.
9. Kefas B,Godlewski J,Comeau L,et al.microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma.Cancer Res. 2008;68:3566-72.
10. Jeon HM,Sohn YW,Oh SY,et al.ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2.Cancer Res. 2011;71:3410-21.
11. Jeon H-M,Jin X,Lee J-S,et al.Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.Genes Dev. 2008;22:2028-33.
12. Ben-Hamo R,Efroni S.Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in glioblastoma multiforme progression.Genome Med. 2011;3:77.
13. Sasayama T,Nishihara M,Kondoh T,et al.MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC.Int J Cancer. 2009;125:1407-13.
14. Sun L,Yan W,Wang Y,et al.MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.Brain Res. 2011;1389:9-18.
15. Gabriely G,Yi M,Narayan RS,et al.Human glioma growth is controlled by microRNA-10b.Cancer Res. 2011;71:3563-72.
16. Ujifuku K,Mitsutake N,Takakura S,et al.miR-195, miR-455-3p and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells.Cancer Lett. 2010;296:241-8.
17. Ernst A,Campos B,Meier J,et al.De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures.Oncogene. 2010;29:3411-22.
18. Sasaki K,Kohanbash G,Hoji A,et al.miR-17-92 expression in differentiated T cells: implications for cancer immunotherapy.J Transl Med. 2010;8:17.
19. Silber J,Lim DA,Petritsch C,et al.miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.BMC Med. 2008;6:14.
20. Fowler A,Thomson D,Giles K,et al.miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.Eur J Cancer. 2011;47:953-63.
21. Cortez MA,Nicoloso MS,Shimizu M,et al.miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma.Genes Chromosomes Cancer. 2010;49:981-90.
22. Shibahara J,Kashima T,Kikuchi Y,et al.Podoplanin is expressed in subsets of tumors of the central nervous system.Virchows Arch. 2006;448:493-99.
23. Xia H-F,He T-Z,Liu C-M,et al.MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf.Cell Physiol Biochem. 2009;23:347-58.
24. Shi L,Zhang J,Pan T,et al.MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation.Brain Res. 2010;1312:120-6.
25. Fareh M,Turchi L,Virolle V,et al.The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network.Cell Death Differ. 2012;19:232-44.
26. Kefas B,Comeau L,Floyd DH,et al.The neuronal microRNA miR-326 acts in a feedback loop with Notch and has therapeutic potential against brain tumors.J Neurosci. 2009;29:15161-8.
27. Lee J,Kotliarova S,Kotliarov Y,et al.Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.Cancer Cell. 2006;9:391-403.
28. Kefas B,Comeau L,Erdle N,et al.Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.Neuro-oncology. 2010;12:1102-12.
29. Xia H,Qi Y,Ng SS,et al.MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells.Biochem Biophys Res Commun. 2009;380:205-10.
30. He X,He L,Hannon GJ.The guardian's little helper: microRNAs in the p53 tumor suppressor network.Cancer Res. 2007;67:11099-101.
31. Li Y,Guessous F,Zhang Y,et al.MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes.Cancer Res. 2009;69:7569-76.
32. Li W-B,Ma M-W,Dong L-J,et al.MicroRNA-34a targets Notch1 and inhibits cell proliferation in glioblastoma multiforme.Cancer Biol Ther. 2011;12:477-83.
33. Guessous F,Zhang Y,Kofman A,et al.microRNA-34a is tumor suppressive in brain tumors and glioma stem cells.Cell Cycle. 2010;9:1031-6.
34. Luan S,Sun L,Huang F.MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251.Arch Med Res. 2010;41:67-74.
35. Wei JS,Song YK,Durinck S,et al.The MYCN oncogene is a direct target of miR-34a.Oncogene. 2008;27:5204-13.
36. Conti A,Aguennouz M,La Torre D,et al.miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors.J Neurooncol. 2009;93:325-32.
37. Gillies JK,Lorimer IAJ.Regulation of p27Kip1 by miRNA 221/222 in glioblastoma.Cell Cycle. 2007;6:2005-9.
38. Lu X,Zhao P,Zhang C,et al.Analysis of miR-221 and p27 expression in human gliomas.Mol Med Report. 2009;2:651-6.
39. Wang X,Han L,Zhang A,et al.Adenovirus-mediated shRNAs for co-repression of miR-221 and miR-222 expression and function in glioblastoma cells.Oncol Rep. 2011;25:97-105.
40. Zhang C,Kang C,You Y,et al.Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo.Int J Oncol. 2009;34:1653-60.
41. Medina R,Zaidi SK,Liu CG,et al.MicroRNAs 221 and 222 bypass quiescence and compromise cell survival.Cancer Res. 2008;68:2773-80.
42. Zhang C,Han L,Zhang A,et al.Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells.Int J Oncol. 2010;36:1503-12.
43. Zhang J,Han L,Ge Y,et al.miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.Int J Oncol. 2010;36:913-20.
44. Zhang C-Z,Zhang J-X,Zhang A-L,et al.MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma.Mol Cancer. 2010;9:229.
45. Ueda R,Kohanbash G,Sasaki K,et al.Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.Proc Natl Acad Sci U S A. 2009;106:10746-51.
46. Lukiw WJ,Cui JG,Li YY,et al.Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM).J Neurooncol. 2009;91:27-32.
47. Moore LM,Zhang W.Targeting miR-21 in glioma: a small RNA with big potential.Expert Opin Ther Targets. 2010;14:1247-57.
48. Chan JA.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.Cancer Res. 2005;65:6029-33.
49. Corsten MF,Miranda R,Kasmieh R,et al.MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.Cancer Res. 2007;67:8994-9000.
50. Papagiannakopoulos T,Shapiro A,Kosik KS.MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.Cancer Res. 2008;68:8164-72.
51. Zhou X,Ren Y,Moore L,et al.Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.Lab Invest. 2010;90:144-55.
52. Kwak H-J,Kim Y-J,Chun K-R,et al.Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.Oncogene. 2011;30:2433-42.
53. Chen Y,Liu W,Chao T,et al.MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G.Cancer Lett. 2008;272:197-205.
54. Li Y,Li W,Yang Y,et al.MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme.Brain Res. 2009;1286:13-8.
55. Shi L,Chen J,Yang J,et al.MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity.Brain Res. 2010;1352:255-64.
56. Ren Y,Zhou X,Mei M,et al.MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol.BMC Cancer. 2010;10:27.
57. Gabriely G,Wurdinger T,Kesari S,et al.MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.Mol Cell Biol. 2008;28:5369-80.
58. Zhou X,Zhang J,Jia Q,et al.Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3.Oncol Rep. 2010;24:195-201.
59. Ren Y,Kang C-S,Yuan X-B,et al.Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro.J Biomater Sci Polym Ed. 2010;21:303-14.
60. Huse JT,Brennan C,Hambardzumyan D,et al.The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.Genes Dev. 2009;23:1327-37.
61. Kim H,Huang W,Jiang X,et al.Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship.Proc Natl Acad Sci U S A. 2010;107:2183-8.
62. Wu N,Zhao X,Liu M,et al.Role of microRNA-26b in glioma development and its mediated regulation on EphA2.PLoS ONE. 2011;6:e16264.
63. Würdinger T,Tannous BA,Saydam O,et al.miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.Cancer Cell. 2008;14:382-93.
64. Smits M,Nilsson J,Mir SE,et al.miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.Oncotarget. 2010;1:710-20.
65. Cui J,Zhao Y,Sethi P,et al.Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation.J Neurooncol. 2010;98:297-304.
66. Zhang Y,Chao T,Li R,et al.MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a.J Mol Med. 2008;87:43-51.
67. Godlewski J,Nowicki MO,Bronisz A,et al.Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal.Cancer Res. 2008;68:9125-30.
68. Wu N,Wu G-C,Hu R,et al.Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128.Acta Pharmacol Sin. 2011;32:345-53.
69. Katakowski M,Zheng X,Jiang F,et al.MiR-146b-5p suppresses EGFR expression and reduces in vitromigration and invasion of glioma.Cancer Invest. 2010;28:1024-30.
70. Xia H,Qi Y,Ng SS,et al.microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs.Brain Res. 2009;1269:158-65.
71. Xu J,Liao X,Wong C.Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG.Int J Cancer. 2010;126:1029-35.
72. Shi L,Cheng Z,Zhang J,et al.hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells.Brain Res. 2008;1236:185-93.
73. Chen G,Zhu W,Shi D,et al.MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2.Oncol Rep. 2010;23:997-1003.
74. Slaby O,Lakomy R,Fadrus P,et al.MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.Neoplasma. 2010;57:264-9.
75. Guan Y,Mizoguchi M,Yoshimoto K,et al.MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance.Clin Cancer Res. 2010;16:4289-97.
76. Dou T,Wu Q,Chen X,et al.A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population.J Cancer Res Clin Oncol. 2010;136:1853-9.
77. Song L,Huang Q,Chen K,et al.miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-B.Biochem Biophys Res Commun. 2010;402:135-40.
78. Tang H,Liu X,Wang Z,et al.Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth.Brain Res. 2011;1390:21-32.
79. Nan Y,Han L,Zhang A,et al.MiRNA-451 plays a role as tumor suppressor in human glioma cells.Brain Res. 2010;1359:14-21.
80. Gal H,Pandi G,Kanner AA,et al.MIR-451 and imatinib mesylate inhibit tumor growth of glioblastoma stem cells.Biochem Biophys Res Commun. 2008;376:86-90.
81. Godlewski J,Nowicki MO,Bronisz A,et al.MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.Mol Cell. 2010;37:620-32.
82. Kim Y,Roh S,Lawler S,et al.miR451 and AMPK mutual antagonism in glioma cell migration and proliferation: a mathematical model.PLoS ONE. 2011;6:e28293.
83. Lee S-T,Chu K,Oh H-J,et al.Let-7 microRNA inhibits the proliferation of human glioblastoma cells.J Neurooncol. 2011;102:19-24.
84. Brett JO,Renault VM,Rafalski VA,et al.The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation.Aging (Albany NY). 2011;3:108-24.
85. Petrocca F,Vecchione A,Croce CM.Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling.Cancer Res. 2008;68:8191-4.
86. Fang L,Deng Z,Shatseva T,et al.MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8.Oncogene. 2010;30:806-21.
87. Garzon R,Marcucci G,Croce CM.Targeting microRNAs in cancer: rationale, strategies and challenges.Nat Rev Drug Discov. 2010;9:775-89.
88. Krützfeldt J,Rajewsky N,Braich R,et al.Silencing of microRNAs in vivo with 'antagomirs'.Nature. 2005;438:685-9.
89. Vester B,Wengel J.LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.Biochemistry. 2004;43:13233-41.
90. Lakomy R,Sana J,Hankeova S,et al.MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients.Cancer Sci. 2011;102:2186-90.