CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-κB activation

Biochemical Pharmacology

Volumn 76, Issue 1, 2008, Pages 79-90

  Lee, Seon Jin ^a   Nam, Woo Dong ^b   Na, Hee Jun ^a   Cho, Young Lai ^a   Ha, Kwon Soo ^a   Hwang, Jong Yun ^b   Lee, Hansoo ^c   Kim, Soon Ok ^d   Kwon, Young Guen ^e   Kim, Young Myeong ^a  

^a Kangwon National University College of Medicine   (South Korea)

^b Kangwon National University College of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

^d Suwon University   (South Korea)

^e Yonsei University   (South Korea)

Author keywords

Cytokines: chemokines; Inflammatory genes; NF B; Rheumatoid arthritis

Indexed keywords

COLLAGEN; CT 20126; CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; COLCHICINE; COLLAGEN; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 45049088307     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.04.006     Document Type: Article

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