Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

Journal of Ethnopharmacology

Volumn 130, Issue 1, 2010, Pages 103-106

  Jaishree, V ^a   Badami, Shrishailappa ^a  

^a JSS COLLEGE OF PHARMACY   (India)

Author keywords

Antioxidant activity; Enicostemma axillare; Gentianaceae; Hepatoprotective; Swertiamarin

Indexed keywords

ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GALACTOSAMINE; SECOIRIDOID; SILYMARIN; SWERTIAMARIN; TRIACYLGLYCEROL; ANTIOXIDANT; GLUCOSIDE; IRIDOID; PLANT EXTRACT; PYRONE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; GENTIANACEAE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CHEMISTRY; DRUG EFFECTS; LIVER; TOXICITY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; FEMALE; GALACTOSAMINE; GENTIANACEAE; GLUCOSIDES; IRIDOIDS; LIVER; MALE; PLANT EXTRACTS; PYRONES; RATS; RATS, WISTAR; IRIDOID GLUCOSIDES;

GENTIANACEAE; RATTUS;

EID: 77953812340     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.04.019     Document Type: Article

References (21)

1. Al-Hazimi H.M.G., Alkhthlan H.Z. Naturally occurring iridoids during the period 1990-1993. Journal of Chemical Society Pakistan. 1996, 18:336-357.
2. Beers R.F., Sizer T.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry 1952, 195:133-140.
3. Baranisrinivasan P., Elumalai E.K., Sivakumar C., Viviyan Therasa S., David E. Hepatoprotective effect of Enicostemma littorale blume and Eclipta alba during ethanol induced oxidative stress in albino rats. International Journal of Pharmacology 2009, 5:268-272.
4. Dinda B., Debnath S., Harigaya Y. Naturally occurring secoiridoids and bioactivity of naturally occurring iridoids and secoiridoids. A review, Part 2. Chemical and Pharmaceutical Bulletin 2007, 55:689-728.
5. Ellman G.L. Tissue sulphydryl group. Archives of Biochemistry and Biophysics 1959, 82:70-77.
6. Garg H.S., Bhandari S.P.S., Tripathi S.E., Patnaik G.K., Puri A., Saxena R., et al. Antihepatotoxic and immunostimulant properties of iridoid glycosides of Scrophularia koelzii. Phytotherapy Research 1994, 8:224-228.
7. Ghisalberti E.L. Biological and pharmacological activity of naturally occurring iridoids and secoiridoids. Phytomedicine 1998, 5:147-163.
8. Jaishree V., Badami S. Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. Planta Medica 2008, 75:12-17.
9. Jaishree V., Badami S., Rupesh Kumar M., Tamizhmani T. Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. Phytomedicine 2009, 16:227-232.
10. Kumarsamy Y., Nahar L., Cox P.J., Jaspars M., Sarker S.D. Bioactivity of secoiridoid glycosides from Centaurium erythraea. Phytomedicine 2003, 10:344-347.
11. Magora H.B., Rahman M.M., Gray A.I., Cole M.D. Swertiamarin from Enicostemma axillare subsp. axillare (Gentianaceae). Biochemical Systematics and Ecology 2003, 31:553-555.
12. Mandal S., Jain R., Mukhopadhyay S. Naturally occurring iridoids with pharmacological activity. Indian Journal of Pharmeutical Sciences 1998, 60:123-127.
13. Masafumi K., Masao K. Studies on the constituents of Swertia japonica. Makino I on the structures of new secoiridoid diglycosides. Chemical and Pharmaceutical Bulletin 2004, 52:1210-1214.
14. Misra H.P., Fridovich I. The role of superoxide anion in the auto-oxidation of epinephrine and simple assay for superoxide dismutase. Journal of Biological Chemistry 1972, 247:3170-3175.
15. Murali B., Upadhyaya U.M., Goyal R.K. Effect of chronic treatment with Enicostemma littorale Blume in non insulin dependent diabetic (NIDDM) rats. Journal of Ethnopharmacology 2002, 81:199-204.
16. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Analytical Biochemistry 1979, 95:351-358.
17. Raju R.W., Radhika S.S., Kunal M.T., Kalpana S.P., Sunil S.J. Screening of roots of Baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats. International Journal of Green Pharmacy 2008, 2:220-223.
18. Rasenack J., Koch H.K., Nowack J., Lesch R., Decker K. Hepatotoxicity of d-GalN in the isolated perfused rat liver. Experimental and Molecular Pathology 1980, 32:264-275.
19. Vishwakarma S.L., Rajani M., Bagul M.S., Goyal R.K. A rapid method for the isolation of swertiamarin from Enicostemma littorale. Pharmaceutical Biology 2004, 42:400-403.
20. Yamahara J., Kobayashi M., Matsuda H., Aoki S. Anticholinergic action of Swertia japonica and an active constituent. Journal of Ethnopharmacology 1991, 33:31-35.
21. Vaidya H., Rajani M., Sudarsanam V., Padh H., Goyal R. Swertiamarin: a lead from Enicostemma littorale Blume. For anti-hyperlipidaemic effect. European Journal of Pharmacology 2009, 617:108-112.