Unraveling the effects of siRNA carrier systems on cell physiology: A multiparametric approach demonstrated on dextran nanogels

Nanomedicine

Volumn 9, Issue 1, 2014, Pages 61-76

  Soenen, Stefaan J ^a   De Backer, Lynn ^a   Manshian, Bella ^b   Doak, Shareen ^b   Raemdonck, Koen ^a   Demeester, Jo ^a   Braeckmans, Kevin ^a   De Smedt, Stefaan ^a  

^a GHENT UNIVERSITY   (Belgium)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

cell viability; genotoxicity; nanogel; nanotoxicity; oxidative stress; siRNA delivery carrier; toxicity mechanism

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DEXTRAN; DEXTRAN NANOGEL; DNA; NANOCARRIER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL MEMBRANE; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG DELIVERY SYSTEM; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; HYDRODYNAMICS; INTRACELLULAR SIGNALING; MTT ASSAY; OXIDATIVE STRESS; PARAMETRIC TEST; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL SURVIVAL; DEXTRANS; DNA DAMAGE; DRUG CARRIERS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RATS; RNA, SMALL INTERFERING;

EID: 84896512895     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.208     Document Type: Article

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