Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice

Metabolism: Clinical and Experimental

Volumn 63, Issue 4, 2014, Pages 593-601

  Lee, Hae In ^a   Yun, Kyeong Won ^a   Seo, Kown Il ^a   Kim, Myung Joo ^b   Lee, Mi Kyung ^a  

^a Sunchon National University   (South Korea)

^b Suseong College   (South Korea)

Author keywords

Alcohol; Hepatic lipid metabolism; High fat; Scopoletin

Indexed keywords

ACETALDEHYDE; ALCOHOL; CATALASE; CHOLESTEROL; FAS ANTIGEN; FATTY ACID; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PHOSPHATIDATE PHOSPHATASE; SCOPOLETIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIPID STORAGE; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ALCOHOL; HEPATIC LIPID METABOLISM; HIGH-FAT; SCOPOLETIN;

ACETALDEHYDE; ADENYLATE KINASE; ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; DIET; ENERGY INTAKE; ETHANOL; LIPID METABOLISM; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED ICR; OBESITY; ORGAN SIZE; SCOPOLETIN; STEROL REGULATORY ELEMENT BINDING PROTEINS;

EID: 84896494617     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.01.003     Document Type: Article

References (34)

1. V. Purohit, B. Gao, and B.J. Song Molecular mechanisms of alcoholic fatty liver Alcohol Clin Exp Res 33 2009 191 205
2. E. Albano Oxidative mechanisms in the pathogenesis of alcoholic liver disease Mol Aspects Med 29 2008 9 16
3. R.B. Ding, K. Tian, and L.L. Huang et al. Herbal medicines for the prevention of alcoholic liver disease: A review J Ethnopharmacol 144 2012 457 465
4. D. Seth, P.S. Haber, and W.K. Syn et al. Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances J Gastroenterol Hepatol 26 2011 1089 1105
5. B.W. Newton, W.K. Russell, and D.H. Russell et al. Liver proteome analysis in a rodent model of alcoholic steatosis J Proteome Res 8 2009 1663 1671
6. H. Everitt, M. Hu, and J.M. Ajmo et al. Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice Am J Physiol Gastrointest Liver Physiol 304 2013 G38 G47
7. H.I. Lee, K.O. Seo, and K.W. Yun et al. Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice J Food Sci 76 2011 T207 T211
8. K.S. Seo, H.J. Jeong, and K.W. Yun Antimicrobial activity and chemical components of two plants, Artemisia capillaris and Artemisia iwayomogi, used as Korean herbal Injin J Ecol Field Biol 33 2010 141 147
9. P.D. Moon, B.H. Lee, and H.J. Jeong et al. Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IkappaB/NF-kappaB signal cascade in the human mast cell line HMC-1 Eur J Pharmacol 555 2007 218 225
10. T. Siatka, and M. Kasparová Effects of auxins on growth and scopoletin accumulation in cell suspension cultures of Angelica archangelica L Ceska Slov Farm 57 2008 17 20
11. R. Mogana, K. Teng-Jin, and C. Wiart Anti-inflammatory, anticholinesterase, and antioxidant potential of scopoletin isolated from Canarium patentinervium Miq. (Burseraceae Kunth) Evid Based Complement Alternat Med 2013 2013 734824
12. S. Panda, and A. Kar Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats Phytother Res 20 2006 1103 1105
13. American institute of nutrition Report of the American Institute of Nurtition Ad Hoc Committee on Standards for Nutritional Studies J Nutr 107 1977 1340 1348
14. K.I. Seo, M.S. Choi, and U.J. Jung et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice Mol Nutr Food Res 52 2008 995 1004
15. G.M. Do, H.Y. Oh, and E.Y. Kwon et al. Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6 J mice Mol Nutr Food Res 55 2011 S173 S185
16. M.S. Choi, M.K. Lee, and U.J. Jung et al. Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet Mol Nutr Food Res 53 2009 751 759
17. E. Bal, S. Ilgin, and O. Atli et al. The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats Hum Exp Toxicol 32 2013 766 774
18. D.W. Crabb, and S. Liangpunsakul Alcohol and lipid metabolism J Gastroenterol Hepatol 3 2006 S56 S60
19. M. Hu, F. Wang, and X. Li et al. Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice Hepatology 55 2012 437 446
20. T.E. Harris, and B.N. Finck Dual function lipin proteins and glycerolipid metabolism Trends Endocrinol Metab 22 2011 226 233
21. A.B. Kohan, I. Talukdar, and C.M. Walsh et al. A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids Biochem Biophys Res Commun 388 2009 117 121
22. T. Porstmann, C.R. Santos, and B. Griffiths et al. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth Cell Metab 8 2008 224 236
23. T. Zeng, and K.Q. Xie Ethanol and liver: Recent advances in the mechanisms of ethanol-induced hepatosteatosis Arch Toxicol 83 2009 1075 1081
24. C. Ji, C. Chan, and N. Kaplowitz Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J Hepatol 45 2006 717 724
25. M.J. Passeri, A. Cinaroglu, and C. Gao et al. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation Hepatology 49 2009 443 452
26. W. Zhong, Y. Zhao, and Y. Tang et al. Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: Role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis Am J Pathol 180 2012 998 1007
27. P. Ferré, and F. Foufelle Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes Obes Metab 12 2010 83 92
28. R. Belfort, L. Mandarino, and S. Kashyap et al. Dose-response effect of elevated plasma free fatty acid on insulin signaling Diabetes 54 2005 1640 1648
29. L. Feng, Y.F. Song, and Q.B. Guan et al. Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes Acta Pharmacol Sin 31 2010 329 340
30. F.J. Gonzalez Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1 Mutat Res 569 2005 101 110
31. A.I. Cederbaum, Y. Lu, and D. Wu Role of oxidative stress in alcohol-induced liver injury Arch Toxicol 83 2009 519 548
32. B. Sid, J. Verrax, and P.B. Calderon Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease Biochem Pharmacol 86 2013 200 209
33. K.S. Murugesh, V.C. Yeligar, and B.C. Maiti et al. Hepato protective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats IJPT 4 2005 64 69
34. X. Yang, C. Dong, and G. Ren Effect of soyasaponins-rich extract from soybean on acute alcohol-induced hepatotoxicity in mice J Agric Food Chem 59 2011 1138 1144