Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner

Experimental Cell Research

Volumn 323, Issue 1, 2014, Pages 144-154

  Park, Eun Jung ^a   Min, Kyoung jin ^a   Choi, Kyeong Sook ^b   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Bcl 2; C FLIP; Dicoumarol; Mcl 1; NQO1; TRAIL

Indexed keywords

CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DICOUMAROL; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN MCL 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DNA CONTENT; DNA FRAGMENTATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; KIDNEY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SKIN FIBROBLAST; THERAPY EFFECT; WESTERN BLOTTING;

BCL-2; C-FLIP; DICOUMAROL; MCL-1; NQO1; TRAIL;

ANIMALS; APOPTOSIS; CARCINOMA, RENAL CELL; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; CREB-BINDING PROTEIN; DICUMAROL; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; INDOLEQUINONES; KIDNEY NEOPLASMS; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NAD(P)H DEHYDROGENASE (QUINONE); NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION, GENETIC;

EID: 84896490449     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.01.009     Document Type: Article

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